Transaxial system models for jPET-D4 image reconstruction

Yamaya, Taiga; Hagiwara, Naoto; Obi, Takashi; Yamaguchi, Masahiro; Ohyama, Nagaaki; Kitamura, Kazuhiro; Hasegawa, Tomoyuki; Haneishi, Hideaki; Yoshida, Eiji; Inadama, Naoko; Murayama, Hideo

doi:10.1088/0031-9155/50/22/009

Cited by 59 publications

(35 citation statements)

References 17 publications

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“…This high resolution was realized by reducing the LGSO crystal size to 1.44 · 1.44 · 4.5 mm, and the high light output of the LGSO enables discrimination of input signals from different crystals. The DOI information was effective at decreasing degradation in radial resolution due to parallax error (27). The effectiveness of DOI was also demonstrated in the human imaging.…”

Section: Discussionmentioning

confidence: 84%

Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards

et al. 2014

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The aim of this work was to evaluate the performance characteristics of a newly developed dedicated breast PET scanner, according to National Electrical Manufacturers Association (NEMA) NU 4-2008 standards. Methods: The dedicated breast PET scanner consists of 4 layers of a 32 · 32 lutetium oxyorthosilicate-based crystal array, a light guide, and a 64-channel position-sensitive photomultiplier tube. The size of a crystal element is 1.44 · 1.44 · 4.5 mm. The detector ring has a large solid angle with a 185-mm aperture and an axial coverage of 155.5 mm. The energy windows at depth of interaction for the first and second layers are 400-800 keV, and those at the third and fourth layers are 100-800 keV. A fixed timing window of 4.5 ns was used for all acquisitions. Spatial resolution, sensitivity, counting rate capabilities, and image quality were evaluated in accordance with NEMA NU 4-2008 standards. Human imaging was performed in addition to the evaluation. Results: Radial, tangential, and axial spatial resolution measured as minimal full width at half maximum approached 1.6, 1.7, and 2.0 mm, respectively, for filtered backprojection reconstruction and 0.8, 0.8, and 0.8 mm, respectively, for dynamic row-action maximum-likelihood algorithm reconstruction. The peak absolute sensitivity of the system was 11.2%. Scatter fraction at the same acquisition settings was 30.1% for the rat-sized phantom. Peak noise-equivalent counting rate and peak true rate for the ratlike phantom was 374 kcps at 25 MBq and 603 kcps at 31 MBq, respectively. In the image-quality phantom study, recovery coefficients and uniformity were 0.04-0.82 and 1.9%, respectively, for standard reconstruction mode and 0.09-0.97 and 4.5%, respectively, for enhanced-resolution mode. Human imaging provided highcontrast images with restricted background noise for standard reconstruction mode and high-resolution images for enhancedresolution mode. Conclusion: The dedicated breast PET scanner has excellent spatial resolution and high sensitivity. The performance of the dedicated breast PET scanner is considered to be reasonable enough to support its use in breast cancer imaging. Br east cancer is one of the leading causes of cancer death among women worldwide, accounting for 425,000 deaths in 187 countries in 2010 (1). A strategy for reducing breast cancer mortality is early detection for successful treatment. PET systems dedicated to the breast have been under development since 1994, when Thompson et al. reported the feasibility of the first of these systems (2). The dedicated PET systems are intended to have higher photon sensitivity and improved spatial resolution by bringing the detectors close to the breast and by using smaller detector elements than those for whole-body tomography. Most of the dedicated PET systems perform positron emission mammography with 2 planar or curved detector heads that can compress the breast mildly, providing planar and limited-angle tomography images (3-8). Fully tomographic dedicated PET systems have also been introduced. This...

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Section: Discussionmentioning

confidence: 84%

Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards

et al. 2014

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“…In our laboratory, a brain PET scanner, jPET-D4 [19,20], has been developed using four-layer DOI detectors to achieve a spatial resolution better than 2.5 mm within the FOV (transaxial, 312 mm; axial, 260 mm), and an absolute sensitivity higher than 10% at the center of the FOV. The four-layer encoding was achieved using a combination of Anger-logic and pulse shape discrimination; the upper and lower halves were discriminated by the reflector structure, and each half was a phoswich detector composed of two kinds of GSO crystals doped at the Ce concentrations of 0.5 mol% (decay time, 60 ns) and 1.5 mol% [21,22].…”

Section: Introductionmentioning

confidence: 99%

Timing resolution improvement using DOI information in a four-layer scintillation detector for TOF-PET

Shibuya¹,

Nishikido²,

Tsuda

et al. 2008

Nuclear Instruments and Methods in Physics Research Section A:

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“…Further improvement in the benefits of resolution recovery reconstruction can also be achieved by combining this method with other hardware-driven advanced technologies, such as, those that provide DOI position measurements and TOF information [13,50]. In a recent study, Kadrmas et al [13] showed that when TOF information is utilized in conjunction with resolution recovery modeling, lesion detection performances are improved both in numerical and human observer tests as compared with either technique resolution recovery or TOF alone (Fig.…”

Section: Hybrid Approachesmentioning

confidence: 99%

Technical Advances in Current PET and Hybrid Imaging Systems

Lee¹

2010

TONMEDJ

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Abstract:The continuing efforts of investigators to achieve the best physical and clinical performances from PET (positron emission tomography) and related hybrid cameras (PET/CT and PET/MRI) have led to remarkable technical advances in hardware and software.Time of flight (TOF) information measurement, which has been enabled thanks to the invention of fast, heavy crystals and advances in fast light detection sensors and readout electronics, is used to obtain the PET images of better quality and lesion-detection performance. Statistical reconstruction with resolution recovery and measurements of depth of interaction (DOI) are the useful software-and hardware-wise approaches for enhancing the spatial resolution of reconstructed PET images. These technical advances along with an expansive increase in the number of PET and PET/CT examinations performed are facilitating the widespread use of PET scanners with specific detector structures and arrangements for particular applications or organs. Combined multimodal imaging systems are also in the development mainstream of these PET systems.In this paper, these important technologies (TOF measurements, statistical reconstruction with resolution recovery, DOI detectors, and application-specific PET cameras) that have made major contributions to advances in state-of-the-art clinical and preclinical PET and hybrid systems are reviewed.

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Transaxial system models for jPET-D4 image reconstruction

Cited by 59 publications

References 17 publications

Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards

Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards

Timing resolution improvement using DOI information in a four-layer scintillation detector for TOF-PET

Technical Advances in Current PET and Hybrid Imaging Systems

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