Objective. To study and analyze the effect of perioperative comprehensive nursing intervention on transcatheter arterial chemoembolization (TACE) in patients with primary hepatic carcinoma (PHC). Methods. One hundred and ten patients with PHC diagnosed in our hospital from May 2019 to January 2022 were randomly selected and divided into a control group (n = 55) and an observation group (n = 55) by random number sorting according to odd and even numbers. Patients in the control group received conventional nursing interventions and those in the observation group received comprehensive nursing interventions. The two groups were compared in terms of surgical status, quality of life (QoL), and nursing satisfaction. Results. The operation time, postoperative bed rest time, and hospital stay in the observation group were significantly (
P
<
0.05
) shorter than those in the control group; the observation group had significantly (
P
<
0.05
) higher scores of quality of life, including somatic function, emotional function, role function, social function, and cognitive function than the control group; chemotherapy adverse reactions including fever, abdominal pain, urinary retention, and gastrointestinal reactions in the observation group were significantly less than those in the control group (
P
<
0.05
); the total incidence of complications in the observation group was significantly (
P
<
0.05
) lower than that in the control group. The total satisfaction with nursing care in the observation group was significantly (
P
<
0.05
) higher than that in the control group. Conclusion. The perioperative application of comprehensive nursing intervention in TACE for patients with PHC aids in the smooth operation, improves patients’ QoL, lowers the risk of chemotherapy reactions and complications, and enhances patient satisfaction and nursing quality. These advantages justify a wider perioperative application of comprehensive nursing intervention in TACE clinical practice.