Transient patterns of serotonergic innervation in the rat visual cortex: normal development and effects of neonatal enucleation

Nakazawa, M; Koh, Teizen; Kani, Kazutaka; Maeda, Toshihiro

doi:10.1016/0165-3806(92)90143-k

Cited by 30 publications

(18 citation statements)

References 31 publications

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“…It is also known that elements of the serotonergic system may increase their expression during some periods of cortical development [11] as it is the case of SERT in the visual and somatosensory cortex [7,12,30,32]. The presence of SERT in the Np both in-situ or cultured, would reinforce the hypothesis that there are serotonin recognizing target cells in the fetal Np.…”

Section: Open Accesssupporting

confidence: 55%

“…Up to now it is accepted that regulatory serotonergic messages are displayed through this neuronal axon fiber system, widely distributed [13,[27][28][29]. These elements of the serotonergic system can increase their expression and function during some periods of cortical development [11] as it is the case of SERT, the serotonin transporter, in the visual and in the somatosensory cortices [7,12,30].…”

Section: Discussionmentioning

confidence: 99%

“…The early appearance of serotonergic terminals in the maturating cerebral cortex is particularly intense especially in the sensory areas: visual, somatosensory and auditory [9,11,12]. Mazer et al, [13] reported that experimental decrease of serotonergic signals alters the normal development and maturation of the cerebral cortex, decreasing the synaptic density with a consecutive damage of cognitive development.…”

Section: Introductionmentioning

confidence: 99%

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Molecular signaling of 5-HT<sub>1A</sub> and presence of serotonergic cells in the fetal cerebral cortex

de¹,

Gutiérrez²,

Rodríguez³

2013

WJNS

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Early appearance of the serotonergic system in the fetal brain and the various effects of serotonin (5-HT) on brain morphogenesis, have given support to a neurotrophic role of serotonin. This function of serotonin is accomplished through a system of serotonin nerve terminals in the target regions that involves various 5-HT receptors. In visual, auditory and somatosensory cortex an early and intense serotonergic innervation is particularly important. The neuronal somata of these terminals are normally located in the mesencephalon and they have not been observed in the maturing cerebral cortex, neither in the adult brain. By using immunolabeling techniques, fluorescence and confocal microscopy, we observe the presence of both, 5-HT terminals and 5-HT cells in mesencephalon (Me, E17) and in the neopallium (Np, E13-E16) cocultures. Cells immunopositive to 5-HT and to tryptophan-5-hydroxilase are also observed in the Np on day 12 of culture. These results concerning the unexpected presence of serotonergic cells in the fetal cerebral cortex are interesting and may be of importance in corticogenesis. As it happens with other elements of the serotonergic system, the presence of these phenotypically serotonergic cells in the early cerebral cortex may be transitory and probably supporting cortex maturation processes. The molecular signaling path of the 5-HT 1A receptor has also been identified.

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Section: Open Accesssupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular signaling of 5-HT<sub>1A</sub> and presence of serotonergic cells in the fetal cerebral cortex

de¹,

Gutiérrez²,

Rodríguez³

2013

WJNS

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“…It has been reported that the distribution and density of serotonergic fibers are changed during postnatal development (Foote and Morrison, 1984;Nakazawa et al, 1992;Doli et al, 1996). To the best of our knowledge, however, there are no available data on the content of 5-HT in developing visual cortex.…”

Section: Possible Role Of 5-htmentioning

confidence: 75%

“…In addition, we have found recently that 5-HT inhibits the induction of the LTP of layer II/III field potentials evoked by stimulation of layer IV in rat visual cortex slices (Edagawa et al, 1998a(Edagawa et al, ,b, 1999(Edagawa et al, , 2000. Furthermore, it has been reported that the distribution and density of serotonergic fibers in the visual cortex are changed during postnatal development (Foote and Morrison, 1984;Nakazawa et al, 1992;Doli et al, 1996). Therefore, we hypothesized that 5-HT is responsible for the developmental decrease in visual cortex LTP.…”

Section: Abstract: Long-term Potentiation; Serotonin; Visual Cortex;mentioning

confidence: 99%

Endogenous Serotonin Contributes to a Developmental Decrease in Long-Term Potentiation in the Rat Visual Cortex

2001

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The primary visual cortex shows synaptic plasticity during a postnatal "critical period," and its plasticity declines with development. Indeed, we found a developmental decrease in the induction of long-term potentiation (LTP) in the rat visual cortex. In visual cortex slices obtained from 2-to 3-week-old rats, tetanic stimulation (100 Hz for 1 sec, twice at an interval of 30 sec) of the white matter reproducibly induced LTP of field potentials in layer II/III. However, in slices from 5-week-old rats, the same tetanic stimulation failed to induce LTP. We hypothesized that endogenous serotonin (5-HT) is responsible for the developmental decrease in visual cortex LTP, because the induction of visual cortex LTP was suppressed by the addition of exogenous 5-HT (10 M) and because the amount of 5-HT in the visual cortex increased during development. To test this hypothesis, we investigated the effect of methysergide, a 5-HT receptor antagonist, on the induction of visual cortex LTP. When visual cortex slices from 5-week-old rats were perfused with 50 M methysergide, tetanic stimulation of the white matter induced robust LTP in layer II/III. Furthermore, serotonergic neurons were lesioned by intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT). LTP was induced in visual cortex slices from 5,7-DHT-treated, 5-week-old rats. These results suggest that the induction of visual cortex LTP in 5-week-old rats is suppressed by endogenous 5-HT. 5-HT may be a factor that determines a critical period for synaptic plasticity in the rat visual cortex.

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Retinal influences specify cortico‐cortical maps by postnatal day six in rats and mice

Olavarría

Hiroi

2003

J of Comparative Neurology

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Studies of callosal projections in striate cortex show that the retina is involved in the development of topographical connections. In normal animals callosal fibers connect retinotopically corresponding, nonmirror-symmetric cortical loci, whereas in animals bilaterally enucleated at birth, callosal fibers connect topographically mismatched, mirror-symmetric loci. Moreover, in rodents the overall pattern of visual callosal connections is adult-like by postnatal day 12 (P12). In this study we delayed the onset of retinal deafferentation in rats and mice in order to determine the period when retinal influences are critically needed for the development of retinotopically matched callosal linkages. Callosal maps were revealed by placing small injections of retrogradely and anterogradely transported tracers into different loci of lateral striate cortex. We found that the patterns of callosal linkages in rats enucleated at P12, P8, and P6 were nonmirror-symmetric, as in normally reared rats. In contrast, the patterns of linkages in rats enucleated at P4 closely resembled the mirror-symmetric pattern seen in rats enucleated at birth (P0). A similar reversal in topography (from symmetric to nonsymmetric) occurred in mice when enucleation was delayed from P4 to P6. These findings indicate that retinal input prior to P6, but not prior to P4, is sufficient for specifying normal callosal topography. Moreover, they suggest that development of retinotopically matched callosal linkages depends critically on retinal influences during a brief period between P4 and P6, when callosal connections are still very immature.

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Transient patterns of serotonergic innervation in the rat visual cortex: normal development and effects of neonatal enucleation

Cited by 30 publications

References 31 publications

Molecular signaling of 5-HT<sub>1A</sub> and presence of serotonergic cells in the fetal cerebral cortex

Molecular signaling of 5-HT<sub>1A</sub> and presence of serotonergic cells in the fetal cerebral cortex

Endogenous Serotonin Contributes to a Developmental Decrease in Long-Term Potentiation in the Rat Visual Cortex

Retinal influences specify cortico‐cortical maps by postnatal day six in rats and mice

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Transient patterns of serotonergic innervation in the rat visual cortex: normal development and effects of neonatal enucleation

Cited by 30 publications

References 31 publications

Molecular signaling of 5-HT&lt;sub&gt;1A&lt;/sub&gt; and presence of serotonergic cells in the fetal cerebral cortex

Molecular signaling of 5-HT&lt;sub&gt;1A&lt;/sub&gt; and presence of serotonergic cells in the fetal cerebral cortex

Endogenous Serotonin Contributes to a Developmental Decrease in Long-Term Potentiation in the Rat Visual Cortex

Retinal influences specify cortico‐cortical maps by postnatal day six in rats and mice

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Molecular signaling of 5-HT<sub>1A</sub> and presence of serotonergic cells in the fetal cerebral cortex

Molecular signaling of 5-HT<sub>1A</sub> and presence of serotonergic cells in the fetal cerebral cortex