Transmural dispersion of repolarization and ventricular tachyarrhythmias

Watanabe, Norikazu; Kobayashi, Youichi; Tanno, Kaoru; Miyoshi, Fumito; Asano, Taku; Kawamura, Mitsuru; Mikami, Yoshino; Adachi, Tarou; Ryu, Syunsyou; Miyata, Akira; Kubo, Takashi

doi:10.1016/j.jelectrocard.2004.02.002

Cited by 171 publications

(130 citation statements)

References 19 publications

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“…Another well-investigated index of transmural dispersion of repolarization is TpTe, which was shown to be helpful for predicting the risk for lifethreatening ventricular arrhythmias (21). Furthermore, previous studies reported that prolonged TpTe was associated with ventricular arrhythmia and sudden cardiac death in patients with hypertrophic cardiomyopathy (22), end-stage renal failure (23), inducible ventricular tachycardia (24), recent MI (25), long-QT syndrome (26), operated tetralogy of Fallot (27), and Brugada syndrome (28). TpTe/QT and TpTe/QTC, relatively novel markers for repolarization abnormalities, are not affected by heart rate and body mass in contrast to TpTe (29).…”

Section: Discussionmentioning

confidence: 99%

Assessment of repolarization abnormalities in baseline electrocardiograms of patients with myocarditis

Güneş¹,

Güler²,

Güler³

et al. 2017

Turk J Med Sci

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Background/aim: Myocarditis in the acute phase usually presents with sinus tachycardia but many other arrhythmias might be seen as well. In this study we aimed to investigate repolarization abnormalities in baseline ECG of patients with myocarditis for the first time.Materials and methods: Thirty patients diagnosed with myocarditis and 25 healthy age-matched controls were included. Two different cardiologists measured corrected QT (QTc), QT dispersion (QTd), QT peak (QTp), T wave peak to T wave end (TpTe), TpTe/QT ratio, and TpTe/QTc ratio in 12-lead ECG.Results: When compared with the control group, QTp (P: 0.021), QT (P: 0.003), TpTe (P < 0.001), TpTe/QTc ratio (P < 0.001), and TpTe/ QT ratio (P: 0.005) were significantly higher in patients with myocarditis. A comparison of receiver operating characteristic (ROC) curves was conducted using the Hanley and McNeil method. The area under the curve (AUC) of the electrocardiographic characteristics QT (AUC: 0.736; 95% CI [0.600-0.846]), QTP (AUC: 0.680; 95% CI [0.540-0.799]), and TpTe (AUC: 0.771; 95% CI [0.638-873]) and TpTe/QTc (AUC: 0.774; 95% CI [0.641-0.876]) and TpTe/QT (AUC: 0.726; 95% CI [0.589-0.838]) in myocarditis were not significantly different from each other but all of them were different from 0.5. Conclusion:Baseline ECGs of patients with myocarditis were associated with repolarization abnormalities. These novel findings may be one of the reasons underlying arrhythmic events in patients with myocarditis.

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Section: Discussionmentioning

confidence: 99%

Assessment of repolarization abnormalities in baseline electrocardiograms of patients with myocarditis

Güneş¹,

Güler²,

Güler³

et al. 2017

Turk J Med Sci

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“…It has been shown that the QT interval lengthened and QTd increased after sympathetic system activity or catecholamine discharge [28]. The Tp-e interval and Tp-e/QT ratio have been used as indices of ventricular repolarization to predict ventricular arrhythmias and sudden cardiac death [13][14][15][16][17]. Several investigators have studied repolarization patterns in patients with SCF and have shown that QTd, Tp-e interval and Tp-e/QT ratio were increased compared to controls [11,29].…”

Section: Discussionmentioning

confidence: 99%

“…The Tp-e interval, defined as the duration between the peak and the end of the T wave on a surface ECG, is an indicator of the total dispersion of repolarization [13]. In addition, Tp-e might be a predictor of ventricular tachycardias and cardiovascular mortality [14,15]. However, changes in body weight and heart rate affect the Tp-e interval [16].…”

Section: The Relationship Between Ventricular Repolarization Indexes mentioning

confidence: 99%

The Relationship between Ventricular Repolarization Indexes and Neutrophil to Lymphocyte Ratio in Patients with Slow Coronary Flow

Suner¹,

Yaşar²

2016

Ann Clin Lab Res

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“…Published studies clearly suggest the applicability of Tp-e/QT ratio as a potentially important index of arrhythmogenesis, both under the conditions of short, normal and long QT interval, as well as in congenital and acquired channelopathies. In various high-risk populations, such as, patients with long QT syndrome [36], inducible ventricular tachycardia [37,18], repaired tetralogy of Fallot [38] or Brugada syndrome [39]. T wave peak to end interval had been found to be more prolonged than control patients.…”

Section: Discussionmentioning

confidence: 99%

Relationship between fibroblast growth factor and arrhythmogenesis in normotensive patients with polycystic kidney disease

Karaagac¹,

Yıldız²,

Yontar³

et al. 2015

Eur Res J

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Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening genetic disease [1]. Cardiovascular disease is the leading cause of morbidity and mortality in patients with ADPKD, with over 80% of deaths attributable to coronary artery disease [2,3]. Left ventricular hypertrophy (LVH) is common in these patients, even in the absence of hypertension [4,5]. LVH is also ABSTRACT 106Objectives. Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening genetic disease. Recent prospective studies showed a powerful and dose dependent association between increasing FGF-23 levels and greater risk of mortality among chronic kidney disease patients. In this study, our aim is to evaluate electrocardiogram derived arrhythmogenesis markers such as Tp-e, Tp-e/QT and Tpe/QTc ratio ADPKD. Methods. Data of 31 patients with ADPKD and age-sex matched 26 healthy were gained for study. Electrocardiogram and echocardiogram measurements, various serum markers were compared between groups. Results. FGF-23 was significantly higher, and eGFR was significantly lower in the ADPKD patients. Myocardial thickness was also higher in ADPKD group. Corrected QT dispersion, Tpe, Tp-e/QT and Tp-e/QTc were also compared between groups. All indicators were significantly worse in ADPKD group. In the correlation analyzes, FGF-23 was significantly correlated with Tp-e, Tp-e/QT and p=0.003; r=0.472, p<0.0001; r=0.442, p=0.001, respectively). Conclusions. In this occasion, we suggest that FGF-23, which probably accumulates ventricular electrical remodeling, may be helpful for risk stratification in patients with ADPKD when used with other indicators. Myocardial cell de-arrangement and electrical remodelling due to fibrosis are suggested mechanisms for this effect.

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Transmural dispersion of repolarization and ventricular tachyarrhythmias

Cited by 171 publications

References 19 publications

Assessment of repolarization abnormalities in baseline electrocardiograms of patients with myocarditis

Assessment of repolarization abnormalities in baseline electrocardiograms of patients with myocarditis

The Relationship between Ventricular Repolarization Indexes and Neutrophil to Lymphocyte Ratio in Patients with Slow Coronary Flow

Relationship between fibroblast growth factor and arrhythmogenesis in normotensive patients with polycystic kidney disease

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