5G gateway is an important equipment to solve the requirements of high-speed data transmission and low delay in industrial applications. For example, in factory workshops, 5G gateways are not only used for mobile devices such as AGV, but also for large-scale data transmission and real-time data analysis. In large enclosed industrial places, such as ports and mines, 5G gateways are used for remote control and other operations. In open scenarios such as natural gas pipelines, transmission lines and rivers, 5G gateways are used to realize remote inspection and monitoring. The industrial 5G gateway provides many key capabilities to support industrial applications, including providing equipment access capabilities, data collection capabilities, edge computing capabilities, data processing capabilities, protocol conversion capabilities, data forwarding capabilities, remote configuration management capabilities, security encryption protection capabilities, and anti-interference capabilities. This paper introduces a high-performance 5G industrial smart gateway hardware design scheme to meet the requirements of industrial applications. The actual test shows that the performance of this design scheme on 5G high-speed transmission meets the needs of industrial applications.