Two-dimensional colloidal crystal of soft microgel spheres: Development, preparation and applications

Li, Fangjie; Luo, Yuning; Guo, Yuhang; Zhou, Yue; He, Dongxiu; Xie, Zhipeng; Zhang, Hai-Tao; Liu, Yang

doi:10.1016/j.colsurfb.2022.112358

Cited by 6 publications

(2 citation statements)

References 108 publications

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“…Apart from the physicochemical properties of the gene complexes, the transfection efficiency of gene complexes depends on their optimal formulation, which in turn is a function of the interaction between the carrier and the gene material. Under this scenario, Langmuir monolayers are a versatile and well-established methodology to elucidate the structural and mechanical properties of biomolecules interacting with different systems [ 33 , 34 ]. In this sense, microgel particles at interfaces are currently being intensively studied for their potential use as emulsion stabilizers [ 35 , 36 , 37 , 38 ] as well as for cell adhesion and for haptics as tactile feedback devices [ 39 , 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

Complexation of DNA with Thermoresponsive Charged Microgels: Role of Swelling State and Electrostatics

Maldonado-Valderrama

Yang

Jimenez-Guerra

et al. 2022

Gels

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Micro- and nanogels are being increasingly used to encapsulate bioactive compounds. Their soft structure allows large loading capacity while their stimuli responsiveness makes them extremely versatile. In this work, the complexation of DNA with thermoresponsive microgels is presented. To this end, PEGylated charged microgels based on poly-N-isopropylacrylamide have been synthesized, allowing one to explore the electrostatics of the complexation. Cationic microgels complexate spontaneously by electrostatic attraction to oppositely charged DNA as demonstrated by electrophoretic mobility of the complexes. Then, Langmuir monolayers reveal an increased interaction of DNA with swollen microgels (20 °C). Anionic microgels require the presence of multivalent cations (Ca2+) to promote the complexation, overcoming the electrostatic repulsion with negatively charged DNA. Then again, Langmuir monolayers evidence their complexation at the surface. However, the presence of Ca2+ seems to induce profound changes in the interaction and surface conformation of anionic microgels. These alterations are further explored by measuring adsorbed films with the pendant drop technique. Conformational changes induced by Ca2+ on the structure of the microgel can ultimately affect the complexation with DNA and should be considered in the design. The combination of microstructural and surface properties for microgels offers a new perspective into complexation of DNA with soft particles with biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Complexation of DNA with Thermoresponsive Charged Microgels: Role of Swelling State and Electrostatics

Maldonado-Valderrama

Yang

Jimenez-Guerra

et al. 2022

Gels

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“…The potential acoustoresponsiveness of PNIPAM microgels can find exciting applications in the realm of smart coatings. By assembling 2D crystals of the stimuli-responsive microgels bounded on solid surfaces, functional materials with versatile uses, including sensors, active optical devices, and more can be developed [21][22][23] . The US as a fast stimulus with tunable spatiotemporal imposition holds significant potential for further advancements in this field.…”

mentioning

confidence: 99%

Dynamic light scattering for particle characterization subjected to ultrasound: a study on compact particles and acousto-responsive microgels

Stock,

von Klitzing,

Rahimzadeh

2024

Sci Rep

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In this report, we investigate dynamic light scattering (DLS) from both randomly diffusing silica particles and acousto-responsive microgels in aqueous dispersions under ultrasonic vibration. Employing high-frequency ultrasound (US) with low amplitude ensures that the polymers remain intact without damage. We derive theoretical expressions for the homodyne autocorrelation function, incorporating the US term alongside the diffusion term. Subsequently, we successfully combined US with a conventional DLS system to experimentally characterize compact silica particles and microgels under the influence of US. Our model allows us to extract essential parameters, including particle size, frequency, and amplitude of particle vibration, based on the correlation function of the scattered light intensity. The studies involving non-responsive silica particles demonstrate that the US does not disrupt size determination, establishing them as suitable reference systems. In addition, we could be able to experimentally resolve the µs-order motion of particles for the first time. Microgels subjected to the US show the same swelling/shrinking behavior as that induced by temperature but with significantly faster kinetics. The findings of this study have potential applications in various industrial and biomedical fields such as smart coatings and drug delivery that benefit from the characterization of macromolecules subjected to the US. Furthermore, the current work may lead to characterizing the mechanical properties of soft particles based on their vibration amplitude extracted using this method.

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Recent advances in cellulose microgels: Preparations and functionalized applications

Yang

Sha

Zhao

et al. 2023

Advances in Colloid and Interface Science

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Two-dimensional colloidal crystal of soft microgel spheres: Development, preparation and applications

Cited by 6 publications

References 108 publications

Complexation of DNA with Thermoresponsive Charged Microgels: Role of Swelling State and Electrostatics

Complexation of DNA with Thermoresponsive Charged Microgels: Role of Swelling State and Electrostatics

Dynamic light scattering for particle characterization subjected to ultrasound: a study on compact particles and acousto-responsive microgels

Recent advances in cellulose microgels: Preparations and functionalized applications

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