Über die Natur des Ehrlichschen Mäusecarcinoms. Die Bedeutung der Wasserstoffionenkonzentration

Inhibition of an Ehrlich Ascites Tumor In Vivo by Partially Neutralized Solutions of Sodium Lactate

“…Topical application of acids has been investigated recently as a possible adjunct to surgery (Laszlo et al, 1959). The exposure in vitro of ascites cells and of tumor fragments to solutions of extreme pH diminishes their transplantability; earlier work on this (Sugiura et al, 1921 ;Sugiura and Benedict, 1927 ;Sugiura, 1928;Downes, 1929;Krontowski and Magath, 1929;Simoes Raposo, 1933) was summarized in part and extended by Collier (1934), as noted recently by Sugiura (1953). Mlost recently, the anti-tumor activities of over a hundred mono-and di-carboxylic acids have been measured by exposing tumor cells to them in vitro at various pH's for a few minutes before inoculation (Hodes et al, 1960;Morgan et al, 1960;Townsend et al, 1960;Sahasrabudhe et al, 1961 T'olnai and Morgan, 1961and Morgan, , 1962aand Morgan, , 1962bTownsend et al, 1961).…”