Understanding the process-product-performance interplay of spray dried drug-polymer systems through complete structural and chemical characterization of single spray dried particles

Poozesh, Sadegh; Setiawan, Nico; Arce, Freddy; Sundararajan, Pavithra; Rocca, Joseph Della; Rumondor, Alfred C. F.; Wei, Douglas; Wenslow, Robert M.; Xi, Hanmi; Zhang, Shawn; Stellabott, Joyce; Su, Yongchao; Moser, Justin; Marsac, Patrick J.

doi:10.1016/j.powtec.2017.07.042

Cited by 40 publications

(11 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are also several techniques utilising electromagnetic radiation that are sensitive to the volume of the pores. These methods include focused ion beam SEM (FIB-SEM) (Heng et al, 2007;Moghadam et al, 2006;Palmas et al, 2016;Poozesh et al, 2017), confocal laser scanning microscopy (CLSM) ( Barman and Bolin, 2017;Häbel et al, 2017;Marucci et al, 2013), nuclear magnetic resonance (NMR, see section 5), Xray computed microtomography (XµCT, see section 6), and terahertz time-domain spectroscopy (THz-TDS, see section 7). NMR is also a void-space sensitive method as it utilises the interaction of the liquid in the pores and solid phase to reveal structural properties of the porous medium.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of pore structures of pharmaceutical tablets: A review

Markl

Strobel

Schlossnikl

et al. 2018

International Journal of Pharmaceutics

108

View full text Add to dashboard Cite

Traditionally, the development of a new solid dosage form is formulation-driven and less focus is put on the design of a specific microstructure for the drug delivery system. However, the compaction process particularly impacts the microstructure, or more precisely, the pore architecture in a pharmaceutical tablet. Besides the formulation, the pore structure is a major contributor to the overall performance of oral solid dosage forms as it directly affects the liquid uptake rate, which is the very first step of the dissolution process. In future, additive manufacturing is a potential game changer to design the inner structures and realise a tailor-made pore structure. In pharmaceutical development the pore structure is most commonly only described by the total porosity of the tablet matrix. Yet it is of great importance to consider other parameters to fully resolve the interplay between microstructure and dosage form performance. Specifically, tortuosity, connectivity, as well as pore shape, size and orientation all impact the flow paths and play an important role in describing the fluid flow in a pharmaceutical tablet. This review presents the key properties of the pore structures in solid dosage forms and it discusses how to measure these properties. In particular, the principles, advantages and limitations of helium pycnometry, mercury porosimetry, terahertz time-domain spectroscopy, nuclear magnetic resonance and X-ray computed microtomography are discussed.

show abstract

Section: Introductionmentioning

confidence: 99%

Characterisation of pore structures of pharmaceutical tablets: A review

Markl

Strobel

Schlossnikl

et al. 2018

International Journal of Pharmaceutics

108

View full text Add to dashboard Cite

show abstract

“…FIB-SEM images were subject to artifacts intrinsic to the imaging method, including stage drifting, non-uniform illumination, sample de-gassing, curtaining and pore-back 24,25,28,29,30 . An interactive AI technique combines SML and deep learning was used.…”

Section: Artificial Intelligence Image Segmentation Image Management ...mentioning

confidence: 99%

Release Mechanisms and Practical Percolation Threshold for Long-acting Biodegradable Implants: An Image to Simulation Study

Zhang

Nagapudi²,

Shen

et al. 2022

Journal of Pharmaceutical Sciences

Self Cite

View full text Add to dashboard Cite

“…A formação de gotículas por atomização é uma etapa crítica, visto que, influencia diretamente o diâmetro e a porosidade das partículas obtidas (SANDER; PENOVIĆ, 2014). A distribuição do diâmetro das partículas, por sua vez, influencia o tempo de re sidência e as taxas de secagem que podem impactar a estrutura física da partícula (POOZESH et al, 2017).…”

Section: Referencial Teóricounclassified

Soro de leite com hidrólise da lactose: desafios na secagem

Santos¹,

Gomes²,

Paiva³

et al. 2018

Revista do ILCT

View full text Add to dashboard Cite

Para atender a demanda de consumidores que buscam por produtos sem lactose ou com baixo teor de lactose, as indústrias têm diversificado sua gama de produtos ao longo dos anos. Vários produtos lácteos deslactosados já estão bem estabelecidos no mercado, como: leite UHT, iogurte e queijo. Este último possui o soro como seu derivado que é muito utilizado como ingrediente na indústria de alimentos. No entanto, ainda que este mercado tem crescido, o mesmo apresenta desafios tecnológicos na secagem, transporte e estocagem de alguns produtos como o soro deslactosado. O soro tradicional é um produto de difícil manutenção da transição vítrea, com isso, problemas tecnológicos como empedramento e aderência ao equipamento podem ocorrer. Ao hidrolisar a lactose, promove a liberação de glicose e galactose no leite. Estes possuem transição vítrea menor que a da lactose, logo a transição vítrea do produto deslactosado é reduzida. Dessa forma, o soro deslactosado torna-se ainda mais difícil de secar. Com isso, as indústrias têm buscado quais os melhores parâmetros de operação para secagem, juntamente com modificações na composição que favoreçam a manutenção do estado vítreo do soro deslactosado.

show abstract

Understanding the process-product-performance interplay of spray dried drug-polymer systems through complete structural and chemical characterization of single spray dried particles

Cited by 40 publications

References 58 publications

Characterisation of pore structures of pharmaceutical tablets: A review

Characterisation of pore structures of pharmaceutical tablets: A review

Release Mechanisms and Practical Percolation Threshold for Long-acting Biodegradable Implants: An Image to Simulation Study

Soro de leite com hidrólise da lactose: desafios na secagem

Contact Info

Product

Resources

About