Unidirectional water-transport antibacterial trilayered nanofiber-based wound dressings induced by hydrophilic-hydrophobic gradient and self-pumping effects

Qi, Linya; Ou, Kangkang; Hou, Yijun; Yuan, Pingping; Yu, Wen; Li, Xiang; Wang, Baoxiu; He, Jianxin; Cui, Shizhong; Chen, Xiaogang

doi:10.1016/j.matdes.2021.109461

Cited by 76 publications

(29 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The management of peri-wound exudate has been a common but neglected problem during wound treatment (Qi et al, 2021). Thus, prevention and control of peri-wound biofluids, such as timely hemostasis and removal of surplus biofluids, is an integral part of the wound healing process that cannot be ignored (Wang et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

Zhao

Xu²,

Wang³

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Wound infection and excessive exudate can affect the process of wound healing. However, the disadvantage of the anti-microbial wound dressings is that the biological fluids are ineffectively removed. Inspired by making “Chinese Jianbing”, a composite wound nano-dressing was developed consisting of a hydrophilic outer layer (chitosan&polyvinyl alcohol: CTS-PVA) and a hydrophobic inner layer (propolis&polycaprolactone: PRO-PCL) by combining casting and electrospinning methods for effective antibacterial and unidirectional removing excess biofluids. In vitro, the composite wound nano-dressing of PRO-PCL and CTS-PVA (PPCP) could strongly inhibit Pseudomonas aeruginosa. Furthermore, PPCP wound dressing had excellent antioxidant properties and blood coagulation index for effective hemostatic. Importantly, it had a preferable water absorption for removing excess biofluid. In vivo, it had anti-inflammatory properties and promoted collagen Ⅰ preparation, which realized 80% wound healing on day 7. In short, the PPCP wound dressing provides a new direction and option for antibacterial and removes excess biofluid.

show abstract

Section: Introductionmentioning

confidence: 99%

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

Zhao

Xu²,

Wang³

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…The contact angle and surface tension were tested by contact angle measuring instrument at room temperature (KRUSS Cluis DSA25, Hamburg, Germany). The water absorption of wound dressing directly affects the wettability of the wound, and a moist environment is beneficial for wound healing [ 22 ]. The swelling rate of our fibers were evaluated in phosphate-buffered saline (PBS, pH = 7.4).…”

Section: Methodsmentioning

confidence: 99%

A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice

Huang

Guan

2021

Marine Drugs

View full text Add to dashboard Cite

Reconstructing the typical analogue of extracellular matrix (ECM) in engineered biomaterials is essential for promoting tissue repair. Here, we report an ECM-mimetic scaffold that successfully accelerated wound healing through enhancing vascularization and regulating inflammation. We prepared an electrospun fiber comprising a brown alga-derived polysaccharide (BAP) and polyvinyl alcohol (PVA). The two polymers in concert exerted the function upon the application of PVA/BAP2 fiber in vivo; it started to reduce the inflammation and promote angiogenesis at the wound site. Our serial in vitro and in vivo tests validated the efficacy of PVA/BAP2 fiber. Particularly, PVA/BAP2 fiber accelerated the repair of a full-thickness skin wound in diabetic mice and induced optimal neo-tissue formation. Generally, our results suggest that, by mimicking the function of ECM, this fiber as an engineered biomaterial can effectively promote the healing efficiency of diabetic wounds. Our investigation may inspire the development of new, effective, and safer marine-derived scaffold for tissue regeneration.

show abstract

“…The mechanical tensile tests of fibers were assessed by material testing machine (CTM2500, Xieqiang Co., ltd, Shanghai, China). The water absorption of the scaffold plays a vital role in wound healing [24]. Then, the water absorbing capability of the fiber was measured in PBS (PH = 7.4).…”

Section: Characterization Of the Fibersmentioning

confidence: 99%

An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice

et al. 2022

View full text Add to dashboard Cite

The design and development of innovative multifunctional wound dressing materials in engineered biomaterials is essential for promoting tissue repair. In this study, nanofibrous wound dressing materials loaded with anti-inflammatory ingredients were manufactured by a promising electrospinning strategy, and their capability for treating diabetic wounds was also investigated. A scaffold blend consisting of an Enteromorpha polysaccharide and polyvinyl alcohol (PVA) was fabricated. The in vitro and in vivo studies confirmed the efficacy of PVA/EPP1 fiber. We found that PVA/EPP1 fiber accelerated the repair of a full-thickness skin wound in diabetic mice. The results suggest that this scaffold could effectively shorten the wound healing time by inhibiting inflammatory activity, which makes it a promising candidate for the treatment of hard-to-heal wounds caused by diabetes.

show abstract

Unidirectional water-transport antibacterial trilayered nanofiber-based wound dressings induced by hydrophilic-hydrophobic gradient and self-pumping effects

Cited by 76 publications

References 38 publications

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice

An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice

Contact Info

Product

Resources

About