Unprovoked seizures represent a challenge in the neurological clinical consult. Identifying a first unprovoked seizure is the first step for an adequate medical approach, for which there are different diagnostic tools that help establish the risk of a second seizure, as well as recurrence factors for a first unprovoked epileptic seizure (UES) or diagnose epilepsy. Pharmacological treatment for a first UES and key points for referral to specialists are similarly established, and we move forward to the reference for the next level of medical attention. In this section we also describe nonmedical recommendation for patients and family members after a first UES. This Mexican Guideline was elaborated accounting for the resources and diagnostic tools available in both public and private hospitals in Mexico.