Urinary infection stones

Bichler, K.-H.; Eipper, E.; Naber, Kurt G.; Braun, Volker; Zimmermann, R.; Lahme, Sven

doi:10.1016/s0924-8579(02)00088-2

Cited by 278 publications

(273 citation statements)

References 24 publications

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“…It is, however, an emerging cause of complicated UTIs, including infected kidney stones (11,(47)(48)(49) and CAUTIs (4,8,9,12,21). Here we resolve this paradox by demonstrating that MRSA exploits the presence of Fg that is released as part of an inflammatory response induced by the presence of a foreign body.…”

Section: Discussionmentioning

confidence: 85%

“…However, recent epidemiologic studies indicate that S. aureus is an emerging cause of UTI in special patient populations, such as pregnant women and those with complicated UTI (4)(5)(6)(7)(8)(9)(10). Complicated S. aureus UTIs are predominately associated with the presence of foreign bodies (i.e., urinary catheters or kidney stones) (4,9,11,12), recent hospital exposure (8), residence in a long-term care facility (6,13), and other comorbidities such as prostatic abscesses following prostatitis, diabetes, and cancer (14,15). Of particular concern, complicated S. aureus UTIs are frequently associated with the development of severe sequelae, leading to increased rates of morbidity and mortality (4,6,8,12,13,(16)(17)(18).…”

mentioning

confidence: 99%

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Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract

Walker

Flores-Mireles

Pinkner

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

103

164

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Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging cause of catheter-associated urinary tract infection (CAUTI), which frequently progresses to more serious invasive infections. We adapted a mouse model of CAUTI to investigate how catheterization increases an individual's susceptibility to MRSA UTI. This analysis revealed that catheterization was required for MRSA to achieve high-level, persistent infection in the bladder. As shown previously, catheter placement induced an inflammatory response resulting in the release of the host protein fibrinogen (Fg), which coated the bladder and implant. Following infection, we showed that MRSA attached to the urothelium and implant in patterns that colocalized with deposited Fg. Furthermore, MRSA exacerbated the host inflammatory response to stimulate the additional release and accumulation of Fg in the urinary tract, which facilitated MRSA colonization. Consistent with this model, analysis of catheters from patients with S. aureus-positive cultures revealed colocalization of Fg, which was deposited on the catheter, with S. aureus. Clumping Factors A and B (ClfA and ClfB) have been shown to contribute to MRSA-Fg interactions in other models of disease. We found that mutants in clfA had significantly greater Fg-binding defects than mutants in clfB in several in vitro assays. Paradoxically, only the ClfB − strain was significantly attenuated in the CAUTI model. Together, these data suggest that catheterization alters the urinary tract environment to promote MRSA CAUTI pathogenesis by inducing the release of Fg, which the pathogen enhances to persist in the urinary tract despite the host's robust immune response.host-pathogen interactions | MRSA CAUTI | ClfB-fibrinogen interactions

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Section: Discussionmentioning

confidence: 85%

mentioning

confidence: 99%

Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract

Walker

Flores-Mireles

Pinkner

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

103

164

View full text Add to dashboard Cite

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“…Though there is a significant relation between the presence of calculi and UTI, it is not certain which one is the cause and which is the effect, as in the principle "which was the first: the chicken or the egg?". In some situations the chemical contents of calculi may indicate the etiology of calculi, as a chronic UTI can induce the development of magnesium ammonium phosphate based calculi, whereas newer studies presented other types of calculi as well, following UTI (10,19). The urinary calculi are developed mostly de novo in renal site (20).…”

Section: Discussionmentioning

confidence: 99%

Bacteriological evaluation of the non-struvite nephrolithiasis and its association with urinary tract infections

Maier

Man

Chibelean

et al. 2015

Revista Romana De Medicina De Laborator

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“…mirabilis, for example, forms crystal-like biofilms which can contain live bacterial cells [44]. However, the crystals were not investigated further during this project, but could represent an appropriate avenue for future research.…”

Section: Discussionmentioning

confidence: 99%

The potential of photo-deposited silver coatings on Foley catheters to prevent urinary tract infections

Cooper

Pollini

Paladini

2016

Materials Science and Engineering: C

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Catheter-associated urinary tract infection (CAUTI) represents one of the most common causes of morbidity and mortality. The resistance demonstrated by many microorganisms to conventional antibiotic therapies and the in-creasing health-care costs have recently encouraged the definition of alternative preventive strategies, which can have a positive effect in the management of infections.Antimicrobial urinary catheters have been developed through the photo-chemical deposition of silver coatings on the external and luminal surfaces. The substrates are exposed to ultraviolet radiation after impregnation into a silver-based solution, thus inducing the in situ synthesis of silver particles. The effect of the surface treatment on the material was investigated through scanning electron microscopy (SEM) and silver ion release measurements. The ability of microorganisms commonly associated with urinary tract infections was investigated in terms of bacterial viability, proliferation and biofilm development, using Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis as target organisms. The silver coatings demonstrated good distribution of silver particles to the substrate, and proved an effective antibacterial capability in simulated biological conditions.The low values of silver ion release demonstrated the optimum adhesion of the coating. The results indicated a good potential of silver-based antimicrobial materials for prevention of catheterassociated urinary tract infection.

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Urinary infection stones

Cited by 278 publications

References 24 publications

Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract

Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract

Bacteriological evaluation of the non-struvite nephrolithiasis and its association with urinary tract infections

The potential of photo-deposited silver coatings on Foley catheters to prevent urinary tract infections

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