Use of Acridine Orange Leukocyte Cytospin Test in Diagnosis of Neonatal Sepsis

Çaksen, H; Üksel, S Y; Ürşatöztürk, M K; Ümerkan, B S; Çoşkun, Abdulhakim

doi:10.1046/j.1440-1754.2001.0742a.x

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…The early diagnosis of sepsis in newborn infants is an important problem because the early signs and symptoms of septicemia in term or preterm infants are usually nonspecific (2,3). Serum C-reactive protein (CRP), IL0-6, IL-1ra (interleukin-1 receptor antagonist), tumor necrosis factor (TNF)-alpha, soluble TNF receptors (p55 and p75) and circulating intercellular adhesion molecule-1 (cICAM-1) concentration have been used in order to determine early diagnosis of sepsis (1,4,5,6,7,8,9,10,11,12,14,15).…”

Section: Introductionmentioning

confidence: 99%

Serum C-Reactive Protein and Interleukin6 Levels in Neonatal Sepsis

Içağasioğlu

Çaksen²,

Sütçü³

et al. 2002

Acta Med. (Hradec Kralove, Czech Repub.)

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In this article, we studied complete blood count, serum C-reactive protein (CRP) and interleukin (IL-6) levels in 30 newborn infants with sepsis at admission, in the 24th hour of admission and at the end of the treatment. Our purpose was to determine the relationship among these parameters in the early diagnosis of neonatal sepsis. In our study, there was not a significant difference in white blood cell (WBC) and thrombocyte count among the values of the first, 24th hour and end of therapy in the study group (P>0.05). However, there was not a significant difference in B/N ratio among the values at admission, 24th hour and end of therapy in the study group (P>0.05). Both serum CRP and IL-6 levels were found to be significantly higher than those of control subjects at the beginning (P<0.05). Similarly, the values obtained on the 24th hour were also elevated. However, at the end of therapy both decreased to normal level (P<0.05). Based on these data, we think that serum CRP levels only which is a simple method may be used in the diagnosis of neonatal sepsis. However, WBC and serum IL-6 levels may be useful to establish mortality, because there was a statistically significant difference for these parameters between the survivors and deaths (P<0.05).

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Section: Introductionmentioning

confidence: 99%

Serum C-Reactive Protein and Interleukin6 Levels in Neonatal Sepsis

Içağasioğlu

Çaksen²,

Sütçü³

et al. 2002

Acta Med. (Hradec Kralove, Czech Repub.)

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The Relationship Between Scoring Systems and Cytokine Levels in Neonatal Sepsis

Çaksen,

Kurtoglu,

Hallaç

et al. 2003

Ann Acad Med Singap

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In this study, 20 newborn infants with sepsis were evaluated and scored according to the criteria of Töllner and Rodwell and associates. Leukocyte count, serum C-reactive protein (CRP), tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 levels were also studied in all infants. The aim of this study was to determine if a relationship exists between the scoring systems and the cytokine levels in neonatal sepsis. The infants were divided into two groups as blood culture positive and negative. Blood culture was positive in 12 (60%) infants. We did not find a significant difference for leukocyte count, cytokine levels and scoring systems between the blood culture positive and negative groups. However, we found a positive correlation between the scoring systems and serum CRP and TNF-alpha levels (P <0.05), but no correlation with IL-6. In conclusion, we suggest that only serum CRP level without performing scoring and studying serum TNF-alpha concentration may be used in early diagnosis of neonatal sepsis. However, further studies are necessary to define this because of the small sample size of our pilot study.

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Comparative Study in Early Neonates with Septicemia by Blood Culture, Staining Techniques and C – Reactive Protein (CRP)

Dhanalakshmi

2015

JCDR

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Use of Acridine Orange Leukocyte Cytospin Test in Diagnosis of Neonatal Sepsis

Cited by 3 publications

References 3 publications

Serum C-Reactive Protein and Interleukin6 Levels in Neonatal Sepsis

Serum C-Reactive Protein and Interleukin6 Levels in Neonatal Sepsis

The Relationship Between Scoring Systems and Cytokine Levels in Neonatal Sepsis

Comparative Study in Early Neonates with Septicemia by Blood Culture, Staining Techniques and C – Reactive Protein (CRP)

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