Use of DNA Fingerprinting in Identifying the Source Case of Tuberculosis in East Azarbaijan Province of Iran

Asgharzadeh, Mohammad; Shahbabian, K.; Kafil, Hossein Samadi; Rafi, Ali

doi:10.3923/jms.2007.418.421

Cited by 22 publications

(9 citation statements)

References 20 publications

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“…Azeri patients travel to the northwest of Iran for tuberculosis treatment (25 multidrug-resistant tuberculosis, there is a need for more stewardship and control of these patients in order to prevent the outbreak of multidrug-resistant tuberculosis in the region (25,26). This finding supports the proposal for a policy to screen all immigrants to Iran for tuberculosis, especially those from tuberculosis high-burden countries such as Azerbaijan, Pakistan, and Afghanistan.…”

Section: Immigrantssupporting

confidence: 57%

Challenges of Tuberculosis in Iran

Bialvaei

Asgharzadeh

Aghazadeh

et al. 2017

Jundishapur J Microbiol

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Section: Immigrantssupporting

confidence: 57%

Challenges of Tuberculosis in Iran

Bialvaei

Asgharzadeh

Aghazadeh

et al. 2017

Jundishapur J Microbiol

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“…Therefore, TB appears to be under control in northwestern Iran. However, many people with TB in the republic of Azerbaijan come to Iran for diagnosis and/or treatment, as TB treatment is free in Iran (19, 20). Thus, Iran will likely face increasing numbers of patients with TB, especially resistant TB, unless appropriate interventions are taken.…”

Section: Discussionmentioning

confidence: 99%

Molecular Diversity of Mycobacterium tuberculosis Strains in Northwestern Iran

Pourostadi

Rashedi

Poor

et al. 2016

Jundishapur J Microbiol

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Background: Years after the development of antituberculosis (TB) drugs, many people continue to suffer from this disease. To control the spread of TB, strains of the Mycobacterium tuberculosis complex need to be determined, and sources of infection must be identified. Such steps should help to prevent transmission of the infection. Objectives: The aim of this study was to perform molecular genotyping of isolates of the M. tuberculosis complex obtained from patients in northwestern Iran. Methods: One hundred ninety-four culture-positive M. tuberculosis isolates obtained from patients in northwestern Iran were analyzed using the mycobacterial interspersed repetitive unit-exact tandem repeats (MIRU-ETR) method. Results: The MIRU-ETR method distinguished 162 different patterns in the 194 isolates, comprising 23 clusters and 139 unique patterns. Its discriminatory power according to the Hunter-Gaston discriminatory index (HGDI) was 0.9978. The largest cluster contained six isolates. Conclusions: This research indicated that various strains of M. tuberculosis were responsible for TB and that the majority of cases were due to reactivation.

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“…Regarding including and excluding criteria from study, the information of 16 papers was finally analyzed [ Figure 1 ], and the summary of important information is presented in Table 1 . [ 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 ] Methods used for genotyping include insertion sequence 6110-restriction fragment length polymorphism (IS6110-RFLP), spoligotyping, polymorphic GC-rich repetitive sequence-restriction fragment length polymorphism (PGRS-RFLP), mycobacterial interspersed repetitive unit-exact tandem repeat (MIRU-ETR), mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR), and direct repeat-restriction fragment length polymorphism (DR-RFLP). In eight studies, they used a secondary typing method, and eight studies were without a secondary method.…”

Section: Resultsmentioning

confidence: 99%

Role of immigration in tuberculosis transmission to Iran: A systematic review

et al. 2020

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Background: Today, because of increasing immigration and the prevalence of drug-resistant tuberculosis in Iran, identifying intra-community cases is necessary in the country. It will be possible through the use of molecular epidemiologic methods. In this inquiry, in order to determine the role of immigrants in the transmission of specific strains to Iran, the studies have been examined which had been conducted based on molecular epidemiologic methods among Iranians and non-Iranians people. Methods: All studies from 1997 to the end of March 2017 were examined in three databases of PubMed, Scopus, and Google Scholar and finally, 16 studies were selected. Results: The common clustering rate between Iranians and non-Iranians was determined to be 19.8, and the intra-community recent transmission rate was from 0% to 49% with average of 18.1%. The rate of multidrug-resistant tuberculosis (MDR-TB) was 12.5%, which was higher among immigrants, especially Afghans, and a significant number of the strains were Beijing. Conclusions: The studies have shown that migrants, especially Afghans, are more effective in transmitting specific strains of tuberculosis to migratory areas. To control tuberculosis, it is necessary to register of immigrant's health information, while enter to the country, so that, by doing appropriate diagnostic tests, the curing the patients, the transmission of tuberculosis to the country would be prevented.

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Use of DNA Fingerprinting in Identifying the Source Case of Tuberculosis in East Azarbaijan Province of Iran

Cited by 22 publications

References 20 publications

Challenges of Tuberculosis in Iran

Challenges of Tuberculosis in Iran

Molecular Diversity of Mycobacterium tuberculosis Strains in Northwestern Iran

Role of immigration in tuberculosis transmission to Iran: A systematic review

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