Use of ginger to control nausea and vomiting caused by chemotherapy in patients with cervical cancer undergoing treatment

Abstract

Introduction:Uterine cervix tumors have an invasive nature, with the capacity to proliferate to surrounding organs such as the vagina, bladder, and rectum, as well as the capacity for dissemination and involvement of structures distant from its place of origin. According to the International Federation of Gynecology and Obstetrics, patients with stages IB I, IB I microscopic (small dimension <4 cm) are indicated for radiotherapy or adjuvant chemoradiotherapy with cisplatin (40 mg/m2). However, cisplatin has side effects such as hematological implications (anemia, neutropenia, and thrombocytopenia), gastrointestinal disorders (nausea, vomiting, diarrhea, constipation), and fatigue. Zingiber officinale contains bioactive compounds that act on pregnancy and postoperative nausea, chemotherapy-induced nausea and vomiting, and also in the management of fatigue, myalgia, and insomnia. This study aimed to evaluate the effects of ginger on chemotherapy-induced nausea and vomiting in patients with cervical cancer undergoing treatment with cisplatin and radiotherapy.Methods and analyses:A randomized intervention clinical and controlled trial with a triple-blind design is described, comparing the effects of institutional antiemetic therapy alone, as well as in combination with 2 different ginger concentrations.Ethics and dissemination:Due to the nature of the study, we obtained approval from the Division Ethics Committee of Liga Contra o Câncer. All participants signed an informed consent form prior to randomization. The results of this study will be published in peer-reviewed journals. The data collected will also be available in a public repository of data.Trial registration number:This study is registered in the Brazilian Registry of Clinical Trials under number RBR-47yx6p9. This study was approved by the Division Ethics Committee of Liga Contra o Câncer under CAAE 40602320.0.0000.5293.

Gengibre (Zingiber officinale) no Manejo de Náuseas e Vômitos Induzidos por Quimioterapia em Pacientes com Câncer: Revisão Integrativa da Literatura

“…Quadro 1. continuação de Silva et al 21 com pacientes brasileiras diagnosticadas com câncer do colo uterino tratadas com cisplatina associada à radioterapia e que usaram gengibre para NVIQ. A adição do gengibre em pó na terapia antiemética padrão de pacientes com câncer ginecológico em regime de quimioterapia com carboplatina e paclitaxel foi eficiente no manejo da náusea aguda 11 .…”

Effect of Zingiber Officinale in the Management of Nausea and Vomiting Induced by Treatment With Cisplatin Associated With Radiotherapy: A Randomized Controlled Trial

“…This was a triple-blind, randomized, placebo-controlled trial comparing the effects of adding 2 different concentrations of ginger to institutional antiemetic therapy (ondansetron with dexamethasone). 12 Institutional antiemetic therapy was applied to all participants included in the study. It is based on protocols previously published and on formal statements and randomized protocol items (SPIRIT) and Consolidated Assay Reports (CONSORT).…”

“…Placebo capsules were taken with approximately 250 ml of water every 12 h, for a total of 1.000 mg per day, according to the previously published protocol. 12 …”

“…Placebo capsules were taken with approximately 250 ml of water every 12 h, for a total of 1.000 mg per day, according to the previously published protocol. 12 The ginger 500 mg group consisted of patients who received capsules containing 250 mg of ginger extract in white/blue gelatin capsules nº 00. The capsules were swallowed with approximately 250 ml of water every 12 h, totaling 500 mg daily.…”

“…Subsequently, the pharmacist dispensed a bottle of capsules corresponding to the group allocation previously determined by the participant. 12 Adverse effects were assessed by completing the followup sheet by assessing the control of nausea and vomiting according to the Common Terminology Criteria for Adverse Events or CTCAE (nausea/vomiting). 14 The CTCAE for nausea was classified as Grade 1 (loss of appetite with no change in eating habits), Grade 2 (decreased oral intake without significant weight loss, dehydration, or malnutrition), or Grade 3 (inadequate intake of calories or fluids by mouth; tube feeding, parenteral nutrition (TPN) or indication for hospitalization).…”