Use of natural antioxidants for the correction of changes in general and local parameters of lipid peroxidation and antioxidant defense system during experimental eye burn

Gakhramanov, F. S.; Kerimov, K.; Dzhafarov, A. I.

doi:10.1007/s10517-006-0454-z

Cited by 4 publications

(7 citation statements)

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“…Other possible explanations include non-inclusion of control and small sample size. Therefore, considering the previous data on the beneficial effects of antioxidants in chemical burns-induced eye injuries in animals [ 127 , 128 ], together with the limitations of this recent study [ 129 ], it is premature to conclude that honey is not beneficial in the treatment of chemical burns-induced eye injuries in animals. This is in view of the fact that honey has been shown to be beneficial in other eye diseased conditions such as in human patients with dry eye syndrome [ 130 ] or endophthalmitis [ 131 ].…”

Section: Honey: a Novel Antioxidant–evidence From In Vivmentioning

confidence: 90%

“…Visual impairment caused by alkali burns of the corneal and conjunctival surface is considered one of the most devastating injuries to the eye [ 127 , 128 ]. These chemical burns-induced eye injuries are accompanied by increased oxidative stress [ 127 , 128 ]. The beneficial effects of antioxidants in the treatment of these eye injuries have been reported [ 127 , 128 ].…”

Section: Honey: a Novel Antioxidant–evidence From In Vivmentioning

confidence: 99%

“…These chemical burns-induced eye injuries are accompanied by increased oxidative stress [ 127 , 128 ]. The beneficial effects of antioxidants in the treatment of these eye injuries have been reported [ 127 , 128 ]. A study investigated and compared the antioxidant effects of honey and conventional treatment in alkali injury on the eyes of New Zealand White rabbits [ 129 ].…”

Section: Honey: a Novel Antioxidant–evidence From In Vivmentioning

confidence: 99%

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Honey: A Novel Antioxidant

2012

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The global prevalence of chronic diseases such as diabetes mellitus, hypertension, atherosclerosis, cancer and Alzheimer's disease is on the rise. These diseases, which constitute the major causes of death globally, are associated with oxidative stress. Oxidative stress is defined as an “imbalance between oxidants and antioxidants in favor of the oxidants, potentially leading to damage”. Individuals with chronic diseases are more susceptible to oxidative stress and damage because they have elevated levels of oxidants and/or reduced antioxidants. This, therefore, necessitates supplementation with antioxidants so as to delay, prevent or remove oxidative damage. Honey is a natural substance with many medicinal effects such as antibacterial, hepatoprotective, hypoglycemic, reproductive, antihypertensive and antioxidant effects. This review presents findings that indicate honey may ameliorate oxidative stress in the gastrointestinal tract (GIT), liver, pancreas, kidney, reproductive organs and plasma/serum. Besides, the review highlights data that demonstrate the synergistic antioxidant effect of honey and antidiabetic drugs in the pancreas, kidney and serum of diabetic rats. These data suggest that honey, administered alone or in combination with conventional therapy, might be a novel antioxidant in the management of chronic diseases commonly associated with oxidative stress. In view of the fact that the majority of these data emanate from animal studies, there is an urgent need to investigate this antioxidant effect of honey in human subjects with chronic or degenerative diseases.

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Section: Honey: a Novel Antioxidant–evidence From In Vivmentioning

confidence: 90%

Section: Honey: a Novel Antioxidant–evidence From In Vivmentioning

confidence: 99%

Section: Honey: a Novel Antioxidant–evidence From In Vivmentioning

confidence: 99%

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Honey: A Novel Antioxidant

2012

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“…Therapeutic effect on induced model of allergic conjunctivitis Promote epithelialization of the cornea, as well as reduce ocular inflammation and the risk of corneal perforation [33][34][35][36][37]…”

Section: Strongylocentrotus Droebachiensismentioning

confidence: 99%

Marine Natural Products Rescuing the Eye: A Narrative Review

Lixi,

Vitiello,

Giannaccare

2024

Marine Drugs

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Different degrees of visual impairment lead to a decrease in patient wellbeing, which has an adverse effect on many facets of social and professional life. Eye disorders can affect several parts of the eye, most notably the retina and the cornea, and the impacted areas might share a common form of cellular damage or dysfunction (such as inflammation, oxidative stress and neuronal degeneration). Considering that marine organisms inhabit a broad variety of marine habitats, they display a great degree of chemical diversity. As a result, molecules with a marine origin are receiving more and more attention in the hopes of developing novel therapeutic approaches. For instance, fucoxanthin has been demonstrated to be effective in protecting the retina against photo-induced damage, while largazole, astaxanthin and spirulina have all shown antioxidant, anti-inflammatory and antiapoptotic activities that can be useful for the management of several ocular diseases, such as age-related macular degeneration and ocular surface disorders. The aim of this review is to analyze the scientific literature relating to the therapeutic effects on the eye of the main natural marine products, focusing on their mechanism of action and potential clinical uses for the management of ocular diseases.

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“…Ech A has been shown to successfully resolve traumatic hemophthalmia in rabbits. Additionally, the effect of Ech A on third-degree alkaline eye burns in rabbits has been studied [ 16 ]. Rabbits receiving subconjunctival injections of Ech A exhibited a decrease in corneal defects on the 10th day postinjection.…”

Section: Clinical Application and Target Molecules Of Ech Amentioning

confidence: 99%

Multifaceted Clinical Effects of Echinochrome

et al. 2021

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The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins. The medicine is clinically used in cardiology and ophthalmology based on the unique properties of Ech A, which simultaneously block various links of free radical reactions. In the last decade, numerous studies have demonstrated the effectiveness of histochrome in various disease models without adverse effects. Here, we review the data on the various clinical effects and modes of action of Ech A in ophthalmic, cardiovascular, cerebrovascular, inflammatory, metabolic, and malignant diseases.

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Use of natural antioxidants for the correction of changes in general and local parameters of lipid peroxidation and antioxidant defense system during experimental eye burn

Cited by 4 publications

References 0 publications

Honey: A Novel Antioxidant

Honey: A Novel Antioxidant

Marine Natural Products Rescuing the Eye: A Narrative Review

Multifaceted Clinical Effects of Echinochrome

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