“…1994; Rontoyianni & Mavridis, 1996;Makedonopoulou et al, 1998Makedonopoulou et al, , 1999Makedonopoulou & Mavridis, 2000, 2001, or polar groups with an intermediate tendency to be hydrated favor IM packing. It seems that the latter is true for the SC mode, as shown from the complexes crystallized in SC (Hamilton & Chen, 1988a,b;Caira et al, 1996Caira et al, , 2002Brett et al, 1999;Sanchez-Ruiz et al, 1999). However, it is dif®cult to deduce some clear relation between guest nature and the IM and SC packing modes.…”