Value of a panel of antibodies to identify the primary origin of adenocarcinomas presenting as bladder carcinoma

Torenbeek, R.; Lagendijk, Jaap H.; Diest, Paul J. van; Bril, Herman; Molengraft, F. J. J. M. Van De; Meijer, Chris J.L.M.

doi:10.1046/j.1365-2559.1998.00328.x

Cited by 89 publications

(61 citation statements)

References 28 publications

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“…Primary adenocarcinoma of the urological region requires differentiation from more common metastatic adenocarcinomas, including direct, lymphatic and hematogenous spread (22,23). The principal primary organs to be considered include the prostate, colon, female genital tract, appendix, stomach and breast (22,23).…”

Section: Discussionmentioning

confidence: 99%

Primary adenocarcinoma of the renal pelvis, ureter and the urinary bladder: A case report and review of the literature

2016

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Abstract. Primary adenocarcinoma is a rare type of urological neoplasm. The present study reports the case of a 55-year-old man with multifocal adenocarcinoma of the renal pelvis, ureter and urinary bladder that occurred in association with a large cystic calculus and perinephric abscess. The patient had suffered from gross hematuria for 2 years and right flank pain for 2 months. Following a series of investigations, a large cystic calculus with multiple tumors in the renal pelvis and ureter was identified. Multifocal tumors and a large calculus were located in the bladder using a cystoscope. The pathological report of 3 individual biopsies revealed a moderately differentiated tubular adenocarcinoma. Right nephrectomy, ureterectomy, radical cystectomy and left ureterocutaneostomy were performed. The pathological investigation revealed a moderately differentiated adenocarcinoma of the renal pelvis, ureter and urinary bladder. No additional treatment was administered and the patient remains alive at follow-up without disease recurrence or metastasis. Although uncommon, the development of a tumor is possible in patients that possess long-standing urolithiasis, particularly when accompanied by hydronephrosis or infection.

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Section: Discussionmentioning

confidence: 99%

Primary adenocarcinoma of the renal pelvis, ureter and the urinary bladder: A case report and review of the literature

2016

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“…15,16,21 The typical colonic adenocarcinoma staining profile, CK7 negative and CK20 positive, has been reported in 29% of primary vesical adenocarcinomas. 15 A combination of CK7 and CK20 by itself does not appear to differentiate primary bladder from colonic adenocarcinomas.…”

Section: 1516mentioning

confidence: 99%

“…The most reliable immunohistochemical marker is prostate-specific antigen, which stains approximately 90% of poorly differentiated prostatic adenocarcinomas and is negative in bladder adenocarcinomas. 3,16 CA 125, which stains the tumor cells of endometrial and ovarian malignancies, has been reported to be of use to differentiate endometrial and ovarian carcinoma from primary bladder adenocarcinomas. 16 Vimentin highlights endometrial carcinoma cells as opposed to bladder adenocarcinoma cells.…”

Section: 1516mentioning

confidence: 99%

“…3,16 CA 125, which stains the tumor cells of endometrial and ovarian malignancies, has been reported to be of use to differentiate endometrial and ovarian carcinoma from primary bladder adenocarcinomas. 16 Vimentin highlights endometrial carcinoma cells as opposed to bladder adenocarcinoma cells. 3 Metastatic breast carcinoma may be differentiated from SRC vesical carcinoma using estrogen receptor and gross cystic disease fluid protein 15, which stain breast carcinoma cells.…”

Section: 1516mentioning

confidence: 99%

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Adenocarcinoma of the Urinary Bladder

Parwani¹

2011

Archives of Pathology &Amp; Laboratory Medicine

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N Primary adenocarcinoma of urinary bladder is an uncommon neoplasm and is a source of diagnostic confusion with adenocarcinomas arising in adjacent organs, especially colon. These tumors show varied histologic picture and degree of differentiation. Clinical association with bladder exstrophy and schistosomiasis has been well documented. Primary bladder adenocarcinomas have overlapping histologic and immunohistochemical features with adenocarcinomas arising from other primary sites and the suggested immunohistochemical panel includes cytokeratins 7 and 20, 34bE12, thrombomodulin, CDX2, and b-catenin. Clinical, imaging, histologic, and immunohistochemical correlation should be done while rendering this diagnosis, as prognosis and therapeutic options for primary versus metastatic adenocarcinoma vary widely.

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“…9 Therefore, very few studies of metastatic spread from primary lung cancer to the bladder have been described.…”

Section: Introductionmentioning

confidence: 99%

A rare case of metastatic lung cancer to the bladder

Karle

Barazani

Tareen

2013

CUAJ

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Cancer metastasis to the bladder from non-contiguous sites is very rare. Lung metastasis to the bladder is even more uncommon, with an extensive literature search identifying only four documented cases in the past 20 years. Of these four cases, only one was from lung adenocarcinoma. In this report, we present the case of a 66-year-old male with known lung adenocarcinoma found to have the incidental finding of a bladder mass upon computed tomography imaging. Histochemical staining of samples from the bladder confirmed metastatic dissemination from the primary lung malignancy.

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Value of a panel of antibodies to identify the primary origin of adenocarcinomas presenting as bladder carcinoma

Cited by 89 publications

References 28 publications

Primary adenocarcinoma of the renal pelvis, ureter and the urinary bladder: A case report and review of the literature

Primary adenocarcinoma of the renal pelvis, ureter and the urinary bladder: A case report and review of the literature

Adenocarcinoma of the Urinary Bladder

A rare case of metastatic lung cancer to the bladder

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