Vascular endothelial growth factor gene polymorphisms and intracranial aneurysms

Fontanella, Marco Maria; Gallone, Salvatore; Panciani, Pier Paolo; Garbossa, Diego; Stefini, Roberto; Latronico, Nicola; Rubino, Elisa; Marengo, Nicola; Ducati, Alessandro; Pinessi, Lorenzo; Rainero, Innocenzo

doi:10.1007/s00701-013-1779-9

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…; Fontanella et al. ). There was no genome‐wide association study (GWAS) relevant to VEGF gene variants and stroke.…”

Section: Resultsmentioning

confidence: 98%

“…After systematically reading full texts, we excluded another 21 articles. Finally, 10 case-control studies with a total of 4233 patients with stroke and 3838 control subjects met our inclusion criteria for qualitative data analysis (Rueda et al 2005;Li and Jin 2007;Liu et al 2007;Zhang et al 2007Zhang et al , 2014Li et al 2009;Fu et al 2011;Kim et al 2011;Yu et al 2012;Fontanella et al 2013). There was no genome-wide association study (GWAS) relevant to VEGF gene variants and stroke.…”

Section: Resultsmentioning

confidence: 99%

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The association between vascular endothelial growth factor gene polymorphisms and stroke: a meta‐analysis

Qiu

Wang

et al. 2016

Brain and Behavior

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ObjectivesNumerous studies have investigated the relationships between vascular endothelial growth factor (VEGF) gene polymorphisms and stroke. However, their findings remain controversial. The objective of this study was to evaluate the relationships between VEGF gene polymorphisms and stroke by a meta‐analysis.Materials and methodsThe PubMed, Embase, China National Knowledge Infrastructure database, Wanfang Chinese database, and VIP Chinese database were systemically searched. Data were extracted by two independent reviewers, and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated.ResultsTen studies were included, including a total of 2331 cases and 1814 controls for +936C>T, 3040 cases and 2649 controls for −1154G>A. Under the dominant and recessive models, respectively, the overall ORs and 95% CIs of +936 T were 1.44, 1.09–1.90, P = 0.01 (1.53, 1.14–2.05, P = 0.005, in Asians) and 1.19, 0.85–1.65, P = 0.31, and the overall ORs and 95% CIs of −1154 A were 0.98, 0.87–1.10, P = 0.75 and 0.95, 0.82–1.11, P = 0.53. No publication bias was found in this meta‐analysis.ConclusionsThe meta‐analysis showed that +936C>T may be a risk factor for stroke, especially in Asians, while −1154G>A was not associated with stroke.

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“…; Fontanella et al. ). There was no genome‐wide association study (GWAS) relevant to VEGF gene variants and stroke.…”

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

The association between vascular endothelial growth factor gene polymorphisms and stroke: a meta‐analysis

Qiu

Wang

et al. 2016

Brain and Behavior

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“…In the literature, it is shown that the messenger ribonucleic acid expression of tumor necrosis factor-α (TNF-α) and Fas-associated death domain protein (FADD) are increased in human cerebral aneurysms, suggesting a key role for these cytokines in promoting inflammation and subsequent apoptosis of cerebral vascular cells with development of an aneurysm sac [ 8 ]. Furthermore, immunostaining studies on vascular endothelial growth factor (VEGF) suggest that the VEGF gene plays a role in the pathogenesis and enlargement of cerebral aneurysms [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Intracranial aneurysms and optic glioma – an unusual combination: a case report

et al. 2016

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BackgroundThe coexistence of glial high grade tumors (glioblastoma, anaplastic astrocytoma) and cerebral aneurysms is common but the association with optic glioma is rare. The treatment of these associated lesions is problematic.Case presentationA 36-year-old white woman presented to our institution with recurrent attacks of headache. Her preoperative radiological studies revealed a lesion of her left optic nerve with extension to the optic chiasma, an aneurysmatic dilatation of the left carotid bifurcation, a second aneurysm on the left of her middle cerebral artery, and a third one on her right anterior cerebral artery in the A2 tract. A left pterional approach was used to remove the tumor and clip the three aneurysmatic dilatations in a single stage.ConclusionsWe report this unusual case of optic glioma associated to multiples aneurysms and review the pertinent literature. An adequate knowledge of this association is mandatory to plan the correct approach to avoid complications.

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“…Genetic alterations were associated with ischemic stroke ( 24 – 41 ), arrhythmias ( 42 – 51 ), coronary heart/artery disease ( 52 – 62 ), myocardial infarction ( 63 – 66 ), and carotid sclerosis ( 67 – 70 ) were intensely investigated, but less attention was paid to the following traits/phenotypes as an outcome: atrial fibrillation ( 71 ), abdominal aorta aneurysm ( 72 ), carotid intima-media thickness ( 73 , 74 ), carotid plaque thickness ( 75 ), cardiovascular mortality/diseases in general ( 76 – 80 ), dilated cardiomyopathy ( 81 , 82 ), venous thrombosis ( 83 – 85 ), familial hypercholesterinaemia ( 86 ), hypertrophic cardiomyopathy ( 87 – 89 ), plasma lipoproteins ( 90 ), hypertension ( 91 – 93 ), intracranial aneurysm ( 94 , 95 ), intracerebral hemorrhage ( 96 – 98 ), ischemic heart disease ( 99 ), recanalization after ischemic stroke ( 100 ), subarachnoid hemorrhage ( 101 – 103 ), vasodilator reactivity ( 104 ), and lower extremity artery disease ( 105 ). During recent years, a number of review articles have appeared dealing with recent advances in genetics research (mostly reviews of association studies) of arrhythmia ( 106 – 108 ), coronary artery/heart disease ( 78 , 109 – 114 ), sudden cardiac death ( 115 , 116 ), sporadic heart failure ( 117 , 118 ), cardiomyopathy ( 119 ), and thrombophilia ( 120 , 121…”

Section: Resultsmentioning

confidence: 99%

Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review

Fiatal

Ádány

2018

Front. Public Health

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BackgroundAlthough largely preventable, cardiovascular diseases (CVDs) are the biggest cause of death worldwide. Common complex cardiovascular disorders (e.g., coronary heart disease, hypertonia, or thrombophilia) result from a combination of genetic alterations and environmental factors. Recent advances in the genomics of CVDs have fostered huge expectations about future use of susceptibility variants for prevention, diagnosis, and treatment. Our aim was to summarize the latest developments in the field from a public health perspective focusing on the applicability of data on single-nucleotide polymorphisms (SNPs), through a systematic review of studies from the last decade on genetic risk estimating for common CVDs.MethodsSeveral keywords were used for searching the PubMed, Embase, CINAHL, and Web of Science databases. Recent advances were summarized and structured according to the main public health domains (prevention, early detection, and treatment) using a framework suggested recently for translational research. This framework includes four recommended phases: “T1. From gene discovery to candidate health applications; T2. From health application to evidence-based practice guidelines; T3. From evidence-based practice guidelines to health practice; and T4. From practice to population health impacts.”ResultsThe majority of translation research belongs to the T1 phase “translation of basic genetic/genomic research into health application”; there are only a few population-based impacts estimated. The studies suggest that an SNP is a poor estimator of individual risk, whereas an individual’s genetic profile combined with non-genetic risk factors may better predict CVD risk among certain patient subgroups. Further research is needed to validate whether these genomic profiles can prospectively identify individuals at risk to develop CVDs. Several research gaps were identified: little information is available on studies suggesting “Health application to evidence-based practice guidelines”; no study is available on “Guidelines to health practice.” It was not possible to identify studies that incorporate environmental or lifestyle factors in the risk estimation.ConclusionCurrently, identifying populations having a larger risk of developing common CVDs may result in personalized prevention programs by reducing people’s risk of onset or disease progression. However, limited evidence is available on the application of genomic results in health and public health practice.

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Vascular endothelial growth factor gene polymorphisms and intracranial aneurysms

Abstract: Our data suggest that the VEGF gene is not a major genetic risk factor for aneurysmal subarachnoid hemorrhage.

Cited by 9 publications

References 25 publications

The association between vascular endothelial growth factor gene polymorphisms and stroke: a meta‐analysis

The association between vascular endothelial growth factor gene polymorphisms and stroke: a meta‐analysis

Intracranial aneurysms and optic glioma – an unusual combination: a case report

Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review

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