VEGFR2-targeted ultrasound molecular imaging of angiogenesis to evaluate liver allograft fibrosis

Abstract

The study highlighted the potential of VEGFR2-targeted USMI as an effective monitoring tool for liver allograft fibrosis.

Novel anti-VEGFR2 antibody-conjugated nanobubbles for targeted ultrasound molecular imaging in a rabbit VX2 hepatic tumor model

“…[32][33][34] In the reported studies, Qiu et al designed a VEGFR2-specific microbubble UCA for molecular imaging, and the presence of tumor imaging was confirmed based on a rat liver allograft fibrosis model. 35 Wei et al evaluated the behavior of microbubbles targeting VEGFR2 using an orthotopic model of renal cell carcinoma. 24 VEGFR2-targeted microbubble UCAs are used for ultrasound molecular imaging of tumor angiogenesis preclinically 36,37 and in clinical studies.…”