Nanotechnology offers the promise of enabling revolutionary advances in diverse areas ranging from electronics, optoelectronics, and energy to healthcare. Underpinning the realization of such advances are the nanoscale ma te rials and corresponding nanodevices central to these application areas. Semiconductor nanowires and nanobelts are emerging as one of the most powerful and diverse classes of functional nanoma terials that are having an impact on science and technology. In this issue of MRS Bulletin, several leaders in this vibrant field of research present brief reviews that highlight key aspects of the underlying ma te rials science of nanowires, basic device functions achievable with these ma te rials, and developing applications in electronics and at the interface with biology. This ar ticle introduces the controlled synthesis, patterned and designed self -assembly, and unique applications of nanowires in nanoelectronics, nano -optoelectronics, nanosensors, nanobiotechnology, and energy harvesting.