Visual detection of in vitro nucleic acid replication by submicro- and nano-sized materials

Magnetic Nylon 6 Nanocomposites for the Microextraction of Nucleic Acids from Biological Samples

“…Magnetic nanoparticles (MNPs) have broad application prospects in various molecule loading and separation applications due to their unique properties [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. MNPs represent a significant doorway for biomolecules such as proteins, nucleic acids (NA), and metabolites separation and detection [2,[14][15][16][17][18][20][21][22][23][24][25][26][27][28][29][30]. The possibility of selectively sensing and analyzing single nucleic acid molecules provides rich information about the organism.…”

“…Solid-phase protocols allow more efficient NA isolation than other methods [16,18,28]. Magnetic solid-phase extraction (MSPE) is a fast and easy procedure with high NA yield and purity [18,26,[31][32][33][34][35][36][37][38][39][40][41].…”

Recent advances in the visual detection of ions and molecules based on gold and silver nanoclusters

“…Using the properties of Au/AgNCs that react with substances to change the uorescence intensity, they can be applied to visualization detection, which are divided into uorescence enhancement (turn-on), uorescence quenching (turn-off), and ratiometric uorescence visualization detection. 13,14 Visual detection has a broad prospect in many sensing elds including biochemical analysis, environmental monitoring, biomedicine, and clinical and medical diagnosis. 15,16 In the visual detection procedure, an obvious color or uorescence change is observed using analytes modulated through a direct and indirect reaction between analytes and coloring agents without using complex equipment.…”

“…Using the properties of Au/AgNCs that react with substances to change the fluorescence intensity, they can be applied to visualization detection, which are divided into fluorescence enhancement (turn-on), fluorescence quenching (turn-off), and ratiometric fluorescence visualization detection. 13,14…”