Visualizing peroxynitrite fluxes in myocardial cells using a new fluorescent probe reveals the protective effect of estrogen

Zhang, Jian; Liang, Muwen; Wang, Xu; Li, Yong; Jiao, Xiaoyun; Tang, Bo

doi:10.1039/c9cc02591j

Cited by 20 publications

(6 citation statements)

References 27 publications

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“…The optical sensor named TPE-LL with aggregation-inducing effect (AIE) was constructed by combining a bromo-coumarin derivative to the tetraphenylene through α,β-unsaturated ketene according to previous reports. [39] To demonstrate the photophysical properties of sensor, the fluorescence spectra under different excitation wavelengths were recorded (Figure S1a). The data showed that the optimal excitation wavelength is 370 nm which is consistent with the ultraviolet absorption spectrum tests of sensor system (Figure S1b).…”

Section: Resultsmentioning

confidence: 99%

“…The optical sensor named TPE‐LL with aggregation‐inducing effect (AIE) was constructed by combining a bromo‐coumarin derivative to the tetraphenylene through α,β‐unsaturated ketene according to previous reports [39] . To demonstrate the photophysical properties of sensor, the fluorescence spectra under different excitation wavelengths were recorded (Figure S1a).…”

Section: Resultsmentioning

confidence: 99%

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Visualizing Fingerprints on Porous Objects by an Optical Sensor Minimally Destructive to DNA Based on Aggregation‐Induced Emission

Liang,

Hu,

Zhao

et al. 2023

ChemistrySelect

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Development of latent fingerprints (LFPs) at the scene played the important role in forensic investigations by reconstructing crime trajectory and individualizing suspect. In this work, the optical sensor named TPE‐LL with aggregation‐induced emission property was constructed and used in LFPs visualization. The sensor exhibited a satisfactory linear relationship to tryptophan (Trp) in the range of 1–20 nM with the low detection limit of 0.15 nM. The samples were collected from 60 volunteers, with a total of 7200 impressed samples and 160 natural samples. Significantly, the high‐resolution fingerprints images with high fidelity and contrast containing pore features were obtained from impressed samples left on porous object for 15 days. Meanwhile, the relative complete STR typing profiles of deposited DNA were obtained and the identification rate of DNA after the develop process was 76.5 %, suggesting that the method was low destructive to DNA. The results indicated that the sensor provided promising perspectives on solving the current technical problems in the field of forensic science and technology

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Visualizing Fingerprints on Porous Objects by an Optical Sensor Minimally Destructive to DNA Based on Aggregation‐Induced Emission

Liang,

Hu,

Zhao

et al. 2023

ChemistrySelect

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“…ONOO – is particularly abundant in reperfusion injuries, and due to its dual ROS/RNS reactivity profile, it is often capable of more cytotoxicity than other ROS or free radicals, its overexpression ultimately leading to the loss of cardiomyocytes . To better understand this process, the Tang group created fluorescent probe 128 in 2019 for the detection ONOO – in real time . Probe 128 exhibits high sensitivity and specificity for ONOO – and so could be successfully used to confirm intracellular ONOO – increases during ischemia.…”

Section: Fluorescent Probes For Cardiovascular Diseasesmentioning

confidence: 99%

Fluorescent Probes for Disease Diagnosis

Wang,

Ding,

Groleau

et al. 2024

Chem. Rev.

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The identification and detection of disease-related biomarkers is essential for early clinical diagnosis, evaluating disease progression, and for the development of therapeutics. Possessing the advantages of high sensitivity and selectivity, fluorescent probes have become effective tools for monitoring disease-related active molecules at the cellular level and in vivo. In this review, we describe current fluorescent probes designed for the detection and quantification of key bioactive molecules associated with common diseases, such as organ damage, inflammation, cancers, cardiovascular diseases, and brain disorders. We emphasize the strategies behind the design of fluorescent probes capable of disease biomarker detection and diagnosis and cover some aspects of combined diagnostic/ therapeutic strategies based on regulating disease-related molecules. This review concludes with a discussion of the challenges and outlook for fluorescent probes, highlighting future avenues of research that should enable these probes to achieve accurate detection and identification of disease-related biomarkers for biomedical research and clinical applications. CONTENTS 5.3.

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“…Using α, β-unsaturated ketene as a recognition site for ONOO - , by linking a bromo-coumarin derivative to a tetraphenyl ethylene (TPE)-based motif, Tang et al synthesized a turn-on fluorescent probe 81 (Figure 19 ) 109 . Upon reaction with ONOO - , unsaturated ketene was rapidly oxidized and broken, and released TPE-COOH which presented aggregation-induced fluorescence.…”

Section: Small-molecule-based Fluorescent Probes For Detection Of Ono...mentioning

confidence: 99%

Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications

Sun¹,

Cao²,

Lu³

et al. 2023

Theranostics

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Peroxynitrite (ONOO - ), owing to its high oxidative and nitrating stress, is associated with several physiological processes in addition to various pathological processes, including those related to neurodegenerative diseases and cancer. Detection of ONOO - at the cellular level is of great significance to understand its pathogenesis. To this end, a variety of fluorescent probes based on small molecules and nanoparticles (NPs) have been engineered and applied as excellent tools for imaging of ONOO - in cells as well as in their diverse biological applications. In this review, we highlight representative cases of fluorescent probes based on recognition mechanism and emphasize their response type (ratiometric, two-photon, long-wavelength/near-infrared, and targeting) in ONOO - detection in the last five years. We further discuss their design strategy, sensing mechanism, and application in bio-imaging and describe NP-based probes according to diverse nanoplatforms.

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Visualizing peroxynitrite fluxes in myocardial cells using a new fluorescent probe reveals the protective effect of estrogen

Abstract: A tetraphenyl ethylene (TPE)-based fluorescent probe specific for ONOO− was developed to evaluate and verify the protective effect of estrogen on myocardial cells during OGD/R.

Cited by 20 publications

References 27 publications

Visualizing Fingerprints on Porous Objects by an Optical Sensor Minimally Destructive to DNA Based on Aggregation‐Induced Emission

Visualizing Fingerprints on Porous Objects by an Optical Sensor Minimally Destructive to DNA Based on Aggregation‐Induced Emission

Fluorescent Probes for Disease Diagnosis

Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications

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