Vitamin C in dermatology

Telang, Pumori Saokar

doi:10.4103/2229-5178.110593

Cited by 215 publications

(184 citation statements)

References 14 publications

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“…Salah satu vitamin yang terdapat pada buah labu siam yaitu vitamin C. Vitamin C adalah obat antioksidan kuat yang dapat digunakan secara topikal dalam dermatologi untuk mengobati dan mencegah perubahan terkait dengan photoaging (Telang, 2013 dan mendetoksifikasi (mengurangi sifat racun) (Khomson, 2010). Vitamin C sesuai fungsinya sebagai antioksidan dapat membantu memperlambat atau mencegah proses oksidasi.…”

Section: Pendahuluanunclassified

Analisis Vitamin C dan Protein pada Biji Buah Labu Siam (Sechium edule)

Fadliya¹,

Supriadi²,

Diah³

2018

J. Akad. Kim.

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Chayote seeds are found in the middle of the fruit which have flat structures and white. Those Keywords: Chayote, vitamin C, protein, Kjeldahl, UV-Vis. Pendahuluan 1Indonesia merupakan negara yang kaya akan kandungan alamnya terutama pada tumbuhan. Hal tersebut dapat dilihat dari keanekaragaman tumbuhan yang hidup berupa sayuran, buahbuahan, dan sebagainya. Kelimpahan dari sayuran ini banyak dijadikan bahan makanan sebagai sumber gizi yang dapat bermanfaat bagi manusia. Sumber gizi yang terdapat pada tumbuhan dapat berupa protein, lemak, karbohidrat, zat besi, kalsium, kalium dan sebagainya. Selain kandungan gizi tersebut di dalam sayuran biasanya terdapat vitamin yang diperlukan oleh manusia, seperti yang dikemukakan oleh Khomsam (2003) sayursayuran dan buah-buahan kaya akan kandungan vitamin, mineral, dan zat gizi lainnya yang dibutuhkan oleh tubuh manusia.Sumber gizi dibutuhkan untuk membantu proses yang terjadi dalam tubuh. Di antara sumber gizi yang penting dalam tubuh yaitu protein dan vitamin C. Protein dapat diperoleh dari tumbuhan (protein nabati) dan dapat diperoleh dari hewan (protein hewani). Menurut Winarno (1986), protein berfungsi sebagai pengatur metabolisme, sebagai bahan bakar apabila keperluan energi tubuh tidak terpenuhi oleh lemak dan karbohidrat, dan sebagai zat pembangun jaringan-jaringan baru.Buah labu siam merupakan salah satu sayuran yang mengandung berbagai macam vitamin. Salah satu vitamin yang terdapat pada buah labu siam yaitu vitamin C. Vitamin C adalah obat antioksidan kuat yang dapat digunakan secara topikal dalam dermatologi untuk mengobati dan mencegah perubahan terkait dengan photoaging (Telang, 2013). Vitamin C sebagai antioksidan alami secara luas yang dianjurkan dalam mengobati

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Section: Pendahuluanunclassified

Analisis Vitamin C dan Protein pada Biji Buah Labu Siam (Sechium edule)

Fadliya¹,

Supriadi²,

Diah³

2018

J. Akad. Kim.

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“…Ascorbic acid is the most plentiful antioxidant in human skin. As it is water soluble, it functions in the aqueous compartment of the cell and protects it from oxidative stress by sequentially donating electrons to neutralize the free radicals [47]. Ascorbic acid can protect against UVA-dependent melanogenesis through the improvement of antioxidant defense capacity of melanocytes, and inhibition of NO production through down-regulation of eNOS and iNOS mRNA [48].…”

Section: Melasmamentioning

confidence: 99%

Melanocytes and Oxidative Stress

Diehl¹

2014

Pigmentary Disorders

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“…Although many formulations contain vitamin C, very few are actually effective in topical application because of low concentration, compromised stability on opening of product and exposure to air and light and on account of the form in which the molecule exist which is not absorbed or metabolized. However when a stable formulation delivers a high concentration of the non-esterified, optimal isomer of the antioxidant; inhibition of acute UV, damage erythema, sunburn, tanning chronic UV ageing and skin cancer is inhibited [35]. Individually or combined these various vitamin C forms can slow down hyperactive melanocytes resulting in a fairer skin.…”

Section: Introductionmentioning

confidence: 99%

“…These forms when used individually or together can assist in slowing down hyperactive melanocytes resulting in fairer skin. Lascorbic acid the biologically active and useful form of vitamin C [34] is soluble and functions in the aqueous compartments of the cell apart from the regeneration of the skin's vitamin E, improving synthesis of collagen [35] and offering antioxidant protection also act as a reducing agent blocking the oxidation chain reaction of melanin production at various points. This inhibition of melanin results in a lighter and brighter skin in just a few weeks.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Hydroquinone, Kojic Acid and L-Ascorbic Acid in Some Cosmetic Emulsions

Oyedeji¹,

Akemu²

2017

ijSciences

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Abstract:The presence of skin de-pigmenting agents in cosmetic products, have received considerable attention in Nigeria as a possible source of skin abuse. There has been a call by government for cosmetic products manufacturers to comply with regulatory limits of these additives in their products. This study contributes to the pool of data available on levels of skin de-pigmenting agents in cosmetic products. Fifty cosmetic emulsions for skin use were randomly purchased from some sales outlets in Ibadan, South West Nigeria with the aim of determining the level of hydroquinone, kojic acid and l-ascorbic acid in them. Manufacturer claims were determined by examining the cosmetic package labels. The three de-pigmenting additives were determined simultaneously and quantitatively using High Performance Liquid Chromatography (HPLC). Results show that 96% of the emulsions were manufactured in four different continents namely Africa (42%), North America (32%), Europe (20%), Asia (2%) and undetermined origin (4%) by 28 different manufacturers. 36% of the manufacturers indicated % hydroquinone content to be 2% while no manufacturer indicated kojic and ascorbic acid content. 52% of the emulsions were creams, 44% lotions and 4% milks. 34% of the samples did not contain any of the three de-pigmenting agents, while 50% contained just hydroquinone, 2% kojic acid alone and 2% only ascorbic acid. Both hydroquinone and kojic acid were in 8% of the samples and only 4% contained the three additives. Levels of occurrence of the additives were 0.1 -4.9% hydroquinone, 0.3 -1.3% kojic acid and ascorbic 0.01 -3.6%. The emulsions which contained hydroquinone were mostly from Africa (28%) followed by North America (22%) followed by Europe (8%), while only 2% from Asia and unidentified continent. Samples from Cote de Voire contained higher concentrations of hydroquinone which were greater than 3% in all cases except one. In conclusion, this study showed that hydroquinone is the major skin de-pigmenting agent in cosmetics in Nigeria the Nigerian Market. 22% of the manufacturers used hydroquinone at levels higher than the regulatory limit (2%). 64% of these manufacturers (55% Cote de Voire + 9% others) are from Africa. Only one manufacturer from Nigeria included hydroquinone at a level above regulatory limit.

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Vitamin C in dermatology

Cited by 215 publications

References 14 publications

Analisis Vitamin C dan Protein pada Biji Buah Labu Siam (Sechium edule)

Analisis Vitamin C dan Protein pada Biji Buah Labu Siam (Sechium edule)

Melanocytes and Oxidative Stress

Simultaneous Determination of Hydroquinone, Kojic Acid and L-Ascorbic Acid in Some Cosmetic Emulsions

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