Vitamin D deficiency, insulin resistance and thyroid dysfunction in obese patients: is inflammation the common link?

Răcătăianu, Nicoleta; Leach, N.; Bolboacă, Sorana D.; Cozma, Angela; Dronca, Eleonora; Valea, Ana; Silaghi, Alina; Bîlc, Ana Maria; Ghervan, Cristina

doi:10.1080/00365513.2018.1517420

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…The relationship between 25OHD and IR is complex with many confounding factors. In our analysis, one of them was BMI that had a negative correlation with 25OHD, as previously shown [42]. In univariate analysis, we also obtained an inverse relation (negative Spearman coefficient = −0.182, p = 0.001) explained by the lipophilic character of 25OHDwhen weight is lost, the 25OHD increases [43].…”

Section: Discussionsupporting

confidence: 74%

No Association between 25-Hydroxyvitamin D and Insulin Resistance or Thyroid Hormone Concentrations in a Romanian Observational Study

et al. 2020

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Background and objectives: Vitamin D is involved in insulin resistance through genomic and non-genomic mechanisms. Several observational and randomized studies have discrepant results; some of them showed an improved insulin resistance (IR), and others a neutral effect after vitamin D deficiency is corrected. Materials and Methods: We designed a retrospective observational study that included all women who presented for 33 months in an outpatient clinic in Bucharest, Romania. Results: We analyzed 353 patients with a mean age of 58.5 ± 13.7 years, a mean body mass index (BMI) of 27.36 ± 4.87 kg/m−2, and a mean level of 25-hydroxyvitamin D (25OHD) of 39.53 ± 15.73 ng/mL. There were no differences in the calculated Homeostatic Model Assessment of Insulin Resistance variants 1 and 2 (HOMA-IR) and the Quantitative Insulin Sensitivity Check Index (QUICKI) between women with vitamin D deficit versus normal values. In multivariate analysis, there was no significant relation between 25OHD and the response variables considered by us. Conclusions: We observed a small positive correlation between a higher level of 25OHD and increased glycosylated hemolobin (HbA1c) or IR indices without clinical significance. Other modifiable or non-modifiable factors override 25OHD influence on IR in adult women with a normal serum level and may contribute to the remainder of the variability observed.

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Section: Discussionsupporting

confidence: 74%

No Association between 25-Hydroxyvitamin D and Insulin Resistance or Thyroid Hormone Concentrations in a Romanian Observational Study

et al. 2020

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“…In a genetically predisposed individual to thyroid autoimmunity, Vitamin D deficiency and metabolic syndrome has been linked to increased systemic inflammation and Hashimoto's thyroiditis. [38] Vitamin D deficiency has been linked to increased risk of gestational diabetes and neonatal intensive care admission in women with thyroid autoimmunity. [39]…”

Section: Resultsmentioning

confidence: 99%

Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors

Dutta

Sharma

Aggarwal

et al. 2019

Indian J Endocr Metab

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Background and Aims:In spite of large volume of data linking Vitamin D with cardiovascular morbidity, autoimmunity, cancer, and virtually every organ system, Vitamin D and thyroid is a lesser-known aspect of Vitamin D in clinical practice. This article intends to highlight the current literature on the impact of Vitamin D status and supplementation on thyroid autoimmunity and cancer.Methods:References for this review were identified through searches of PubMed for articles published to from 1950 to August 2019 using the terms “thyroid” [MeSH Terms] AND “Vitamin D” [MeSH Terms] OR “thyroid” [All Fields] AND “Vitamin D” [All Fields].Results:Significant inverse correlation was documented between anti-thyroid peroxidase antibody (TPOAb) and serum 25-hydroxy-Vitamin D (25OHD). TPOAb positivity is more prevalent in Vitamin D deficient individuals. A large volume of medical literature is available from observational studies linking Vitamin D with thyroid autoimmunity. Data from interventional studies documenting beneficial effects of Vitamin D on thyroid autoimmunity is also available, but lesser than that from observational studies. Short-term high dose oral Vitamin D supplementation reduces TPOAb titers. Certain Vitamin D receptor (VDR) gene polymorphism have been linked to increased occurrence of autoimmune thyroid disorders (AITD). Vitamin D deficiency, decreased circulating calcitriol has been linked to increased thyroid cancer. Certain VDR gene polymorphisms have been linked with increased as well as decreased occurrence of thyroid cancer. Data is scant on use of Vitamin D and its analogues for treating thyroid cancer.Conclusion:In spite of large volume of medical literature from observational studies linking Vitamin D with thyroid autoimmunity and cancer, meaningful concrete clinical data on impact of Vitamin D supplementation on hard clinical end points in these disorders is lacking, and should be the primary area of research in the next decade.

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“…The strengths of the study come from the degree of novelty, being one of the rare studies that analysed a complex panel of chemokines in the Romanian population [46] with hypothyroidism and prediabetes, respectively newly diagnosed T2DM. Biochemical and hormonal analyses were performed by the same laboratory, and immunofluorescence determinations by the same experienced research assistant.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-8, CXCL10, CXCL11 and their role in insulin resistance in adult females with subclinical hypothyroidism and prediabetes

Stoica

Drăgana

Ancuceanu

et al. 2022

Journal of Clinical & Translational Endocrinology

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Vitamin D deficiency, insulin resistance and thyroid dysfunction in obese patients: is inflammation the common link?

Cited by 9 publications

References 23 publications

No Association between 25-Hydroxyvitamin D and Insulin Resistance or Thyroid Hormone Concentrations in a Romanian Observational Study

No Association between 25-Hydroxyvitamin D and Insulin Resistance or Thyroid Hormone Concentrations in a Romanian Observational Study

Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors

Interleukin-8, CXCL10, CXCL11 and their role in insulin resistance in adult females with subclinical hypothyroidism and prediabetes

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