Vitamin D Levels in Women with Polycystic Ovary Syndrome

Abstract

Introduction. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. There is some evidence suggested that vitamin D played a role in the incidence of PCOS. Previous research has found vitamin D deficiency in the pathogenesis of PCOS and cohort studies showing the relationship of obesity with decreased levels of 25-hydroxy vitamin D. Therefore, we aim to conduct a study on vitamin D levels in women with polycystic ovary syndrome. Objective. To determine the difference of the levels of vitamin D in women with and without polycystic ovary syndrome. Methods. This study is a comparative analytical study on two unpaired population by using cross-sectional study design. The study was conducted in Halim Fertility Clinic Medan starting in November 2014 through April 2015. Blood samples were taken from 23 women PCOS and 23 non-PCOS women. Further data were tabulated and analyzed. Results. Vitamin D levels are lower in women with PCOS compared to controls. In the PCOS group, the levels of vitamin D were lower in obese women. Vitamin D levels were also lower in PCOS women with WHR > 0.85. Conclusion. This study showed a significant lower level of vitamin D in PCOS patient.

Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis

“…Similarly, in a metaanalysis of seven RCTs of co-supplementation of vitamin D and calcium in overweight and obese patients, the authors found that less than 8 weeks of supplementation led to a statistically significant TG, TC, and LDL-C reduction and an increase in HDL-C levels [39]. Low levels of vitamin D have been identified in polycystic ovary syndrome (PCOS), especially in obese patients and those with a waist-to-hip ratio above 0.85 [40]. Additionally, vitamin D deficiency may be a risk factor in the development of this endocrine-metabolic pathology [41].…”

Poly Cystic Ovarian Syndrome and Vit D Correlation with Fertility : Review Article

“…On the contrary, Ming-Wei et al (6) reported that in spite of the presence of many studies suggesting the association between vitamin D receptor (VDR) gene (one of the genes involved in vitamin D metabolism) and polycystic ovarian syndrome, no consistent conclusion could be made that vitamin D has a significant role in neither the pathophysiology nor the outcome of polycystic ovarian syndrome (6) . (5) 2017 502 Metaanalysis Vit D supplement significantly improved follicular development in PCOS Elida et al (7) 2016 23 patients 23 controls…”

“…Lower levels of vitamin D were associated with insulin resistance, low pregnancy rates, and menstrual irregularities, and signs of hyperandrogenism. Similarly, results from cross-sectional study conducted by Elida et al (7) indicated that PCOS patients had significantly lower vitamin D levels when compared to controls, and obese PCOS ladies had even much lower level of vitamin D specifically those with waist-hip ratio of >0.85.…”

“…However, it did not seem to decrease the time or number of cycles to pregnancy (12) .Results from Irani et al (9) study provided a new possible role of vitamin D supplementation on the pathophysiology of PCOS by acting on TGF-β. Other studies (7,8) assumed a probable role of vitamin D in insulin resistance. It seemed that vitamin D deficiency might aggravate insulin resistance and its correction might help control of the condition.…”

“…As regards the association of vitamin D and polycystic ovarian syndrome, many researchers had observed a significantly lower vitamin D level among PCOS women (8,9,11,12) , it was even lower in obese PCOS (7) . Data indicated that vitamin D supplementation for those patient had improved their follicular development and increased the number of dominant follicles (5) .…”