Assessment of Vitamin D Levels in Women with Polycystic Ovarian Syndrome

Elkholy, Sanaa Sh.; Mostafa, Rowaa A.; Riad, Amr Ahmed Mahmoud; AbouZaghla, Heba M.

doi:10.12816/0043811

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…The results affirm that the vitamin D level was significantly lower in women with PCOS than in those without. This finding is in agreement with those of studies conducted in different countries (8,9,15,18,26,27). It is not consistent with that of a study of women with PCOS living in Makkah, located in the Western region, in which the vitamin D levels were similar among patients and controls (25); nonetheless, a larger study in the same region demonstrated lower levels of vitamin D in women with PCOS (17).…”

Section: Discussionsupporting

confidence: 67%

Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

Bindayel

2021

Front. Nutr.

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. In this study, serum 25-hydroxyvitamin D levels were compared between women with and without PCOS and with regard to anthropometric indices and lipid and glucose biomarkers. Thirty-one women with PCOS and 75 controls answered a questionnaire on vitamin D, in addition to general health and lifestyle. The patients with PCOS had lower vitamin D levels (p < 0.05), a significantly higher rate of obesity (p < 0.05), and significantly higher serum triglyceride levels than did controls. The number of patients with PCOS consumed milk and dairy products (p < 0.05) and exposed to sun (p < 0.006) were lower compared to controls. Triglyceride levels were significantly correlated with body mass index (BMI); vitamin D level was not significantly correlated with anthropometrical or biochemical variables. These results affirm that vitamin D levels are lower in women with PCOS; however, despite the significantly higher proportion of obesity among patients with PCOS, hypovitaminosis was not associated with BMI. The relationship between body composition and vitamin D in PCOS and the effect of vitamin D correction on metabolic and hormonal parameters associated with PCOS must be assessed in future trials.

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Section: Discussionsupporting

confidence: 67%

Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

Bindayel

2021

Front. Nutr.

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“…According to the study done by the proportion of vitamin D deficiency was higher in women with PCOS than in women without PCOS i.e.59.9%,44% and39.1%. 2,6,14 The mean vitamin D level in women with PCOS was low compared to women without PCOS as seen in the studies done by 11.9±6.9 and 7.7±3.9 6,15 16 The strengths of the present study were a single observer study where cases and controls were matched. The estimation of vitamin D was done in CIDRF using proper calibration.…”

Section: Discussionmentioning

confidence: 63%

Serum Vitamin D Levels in Different Phenotypes of Polycystic Ovarian Syndrome (PCOS) A Case-Control Study

Ghose

Manasa

Ravirajan

2022

Int J Life Sci Pharm Res

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Polycystic ovarian syndrome (PCOS) is the most common heterogeneous multisystem endocrinopathy in women of reproductive age, with an ovarian manifestation of various metabolic disturbances. Based on Rotterdam criteria, PCOS is further classified into four phenotypes. Vitamin D deficiency affects 65- 75% of PCOS patients. There is very little research on the relationship between vitamin D deficiency and PCOS phenotypes. As a result, we intended to investigate the relationship between vitamin D, PCOS, and various PCOS phenotypes. This is a case-control study where we had been 100 people in the study. A total of 50 PCOS participants were classified into phenotype A, phenotype B, phenotype C, and phenotype D using Rotterdam criteria. There were 50 participants who did not have PCOS. Serum vitamin D levels were measured in the study population. The CIDRF (Central Inter-Disciplinary Research Facility) used an ELISA kit and reader to quantify vitamins. The results obtained were further classified as deficient (20ng/ml), insufficient (21-29ng/ml), and sufficient (30ng/ml). SPSS version 17 was used to analyse the results. The mean vitamin D level among women with PCOS was 15.9±9.3, women without PCOS was 20.5±9.2, the difference between the means was statistically significant(p-0.015). Among the participants with PCOS Phenotype A accounted for 36%, phenotype B 26%, phenotype C 20%, phenotype D 18%. The serum vitamin D levels among different phenotypes of PCOS was not statistically significant (p-0.978). There was no statistically significant difference in the mean vitamin D levels, among the phenotypes of PCOS (p - 0.978). Vitamin D deficiency was found to be more prevalent in women with PCOS in this study. In PCOS, it is recommended to screen for and treat with vitamin D. There is no significant difference between phenotypes.

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“…Elkholy et al, and Kumar et al found a similar trend. 16,17 In contrast in 2018, Gul et al found that PCOS subjects had higher BMI and the difference reached statistical significance (p value <0.01). 15 The observations in this study showed that 76.7% had increased waist-hip ratio (Table 1) with the mean as 0.87±0.08.…”

Section: Table 3: Distribution Of Subjects Based On Acnementioning

confidence: 93%

Serum 25-OH vitamin D and insulin resistance in women with polycystic ovary syndrome

Chandra

Ansari²

2023

Int J Reprod Contracept Obstet Gynecol

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Background: This was a prospective case control study conducted in the department of obstetrics and gynecology, Era’s Lucknow Medical College and Hospital from November 2018 to March 2020. Aim was to find whether there was a link between serum 25-OH vitamin D levels, and insulin resistance in women with polycystic ovarian syndrome (PCOS). Methods: 30 newly diagnosed cases of PCOS and 30 women without PCOS were enrolled. Their clinical details as well as BMI and waist hip ratio were noted. The biochemical parameters which were measured included fasting glucose, fasting insulin, serum 25-OH vitamin D. The insulin resistance was calculated. Results: 50% of the PCOS had insulin resistance and also deficient /or insufficient vitamin D levels, versus 16.7% in the control group. This association was statistically highly significant with p value as 0.00016. No statistical significance was found with regard to the mean serum 25-OH vitamin D level. 53.4%, of the PCOS women had hirsutism versus 3.3% in the control group and was statistically significant, p value <0.0001. 20% of PCOS women had acne in contrast to 3.3% in the control group which was statistically significant with p value 0.0443. Conclusions: Hirsutism and acne were important clinical signs of PCOS. There was a negative correlation between insulin resistance and serum 25-OH vitamin D levels. Thus, vitamin D may be an important link in the genesis of PCOS. Larger randomised case control studies need to be done to understand PCOS.

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Assessment of Vitamin D Levels in Women with Polycystic Ovarian Syndrome

Cited by 4 publications

References 20 publications

Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

Serum Vitamin D Levels in Different Phenotypes of Polycystic Ovarian Syndrome (PCOS) A Case-Control Study

Serum 25-OH vitamin D and insulin resistance in women with polycystic ovary syndrome

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