Wet-spun bi-component alginate based hydrogel fibers: Development and in-vitro evaluation as a potential moist wound care dressing

Umar, Muhammad Naveed; Ullah, Azeem; Nawaz, Hifza; Areeb, Tanzeel; Hashmi, Motahira; Kharaghani, Davood; Kim, Kyu Oh; Kim, Ick Soo

doi:10.1016/j.ijbiomac.2020.12.088

Cited by 34 publications

(14 citation statements)

References 35 publications

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“…Therefore, increased awareness of this fundamental aspect of wound care, or any trauma, is helping to develop newer strategies and approaches for therapeutic support, and innovative materials to improve the quality of human life. Injured skin can cause serious health problems such as loose thermal insulation, and issues with body fluid, electrolytes, and nutritional components in the human body [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Development of PVA–Psyllium Husk Meshes via Emulsion Electrospinning: Preparation, Characterization, and Antibacterial Activity

et al. 2022

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In this study, polyvinyl alcohol (PVA) and psyllium husk (PSH)/D-limonene electrospun meshes were produced by emulsion electrospinning for use as substrates to prevent the growth of bacteria. D-limonene and modified microcrystalline cellulose (mMCC) were preferred as antibacterial agents. SEM micrographs showed that PVA–PSH electrospun mesh with a 4% amount of D-limonene has the best average fiber distribution with 298.38 ± 62.8 nm. Moreover, the fiber morphology disrupts with the addition of 6% D-limonene. FT-IR spectroscopy was used to analyze the chemical structure between matrix–antibacterial agents (mMCC and D-limonene). Although there were some partial physical interactions in the FT-IR spectrum, no chemical reactions were seen between the matrixes and the antibacterial agents. The thermal properties of the meshes were determined using thermal gravimetric analysis (TGA). The thermal stability of the samples increased with the addition of mMCC. Further, the PVA–PSH–mMCC mesh had the highest value of contact angle (81° ± 4.05). The antibacterial activity of functional meshes against Gram (−) (Escherichia coli, Pseudomonas aeruginosa) and Gram (+) bacteria (Staphylococcus aureus) was specified based on a zone inhibition test. PPMD6 meshes had the highest antibacterial results with 21 mm, 16 mm, and 15 mm against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, respectively. While increasing the amount of D-limonene enhanced the antibacterial activity, it significantly decreased the amount of release in cases of excess D-limonene amount. Due to good fiber morphology, the highest D-limonene release value (83.1%) was observed in PPMD4 functional meshes. The developed functional meshes can be utilized as wound dressing material based on our data.

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Section: Introductionmentioning

confidence: 99%

“…There are numerous studies related to psyllium husk gel used to make fibers by wet spinning [ 6 , 7 , 43 , 44 ]. We know that studies concerning antibacterial nanofibers consisting of PVA–psyllium husk polyblends are not yet available in the literature.…”

Section: Introductionmentioning

confidence: 99%

Development of PVA–Psyllium Husk Meshes via Emulsion Electrospinning: Preparation, Characterization, and Antibacterial Activity

et al. 2022

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“…The bandages, which are an appropriate hemostatic dressing, can promote blood coagulation and epithelial regeneration. Umar et al prepared bi-component alginate-hyaluronic acid (AHA) fibers [ 86 ]. Compared against commercially available alginate wound dressings (Dimora, marketed by Winner Medical Co., Ltd.), the dressing made of AHA fibers had better liquid absorption capacity and cell adhesion, indicating an overall better performance of the fibers produced by dope mixing.…”

Section: Hemostasis Of Superficial Woundsmentioning

confidence: 99%

Application of Alginate-Based Hydrogels in Hemostasis

Xie

Gao

et al. 2022

Gels

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Hemorrhage, as a common trauma injury and clinical postoperative complication, may cause serious damage to the body, especially for patients with huge blood loss and coagulation dysfunction. Timely and effective hemostasis and avoidance of bleeding are of great significance for reducing body damage and improving the survival rate and quality of life of patients. Alginate is considered to be an excellent hemostatic polymer-based biomaterial due to its excellent biocompatibility, biodegradability, non-toxicity, non-immunogenicity, easy gelation and easy availability. In recent years, alginate hydrogels have been more and more widely used in the medical field, and a series of hemostatic related products have been developed such as medical dressings, hemostatic needles, transcatheter interventional embolization preparations, microneedles, injectable hydrogels, and hemostatic powders. The development and application prospects are extremely broad. This manuscript reviews the structure, properties and history of alginate, as well as the research progress of alginate hydrogels in clinical applications related to hemostasis. This review also discusses the current limitations and possible future development prospects of alginate hydrogels in hemostatic applications.

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“…Aminoethyl methacrylate HA Excellent swelling, mechanical property, low cytotoxicity, rapid hemostasis capacity and facilitated wound healing in mice [101] Alginate-HA fibers Good mechanical performance, high liquid absorption, and swelling percentage, high biocompatibility toward nHDF cell line, maintaining a moist wound surface [102] HA-poloxamer Promoted skin-wound healing and increased protein accumulation in the wound area in rats, higher air permeability than Band-aid [103] HA and lysozyme Hydrogel with suitable viscoelasticity and excellent adhesion on the skin tissue, low cytotoxicity [104] γ-Irradiated LMM HA High viability of L929 skin fibroblasts, faster wound healing after two days of healing in rats [105] HA with conjugated azobenzene and β-cyclo-dextrin groups Hydrogel with fast healing of skin wound in rats [106] • NO-releasing HA derivatives Effective against pathogens Staphylococcus aureus and Pseudomonas aeruginosa in skin wounds, enhanced wound closure and decreased quantity of the P. aeruginosa genetic material in the wound tissue in mice wounds [107] HA and cellulose High swelling capacity in various media [108] HA and hydroxyethyl cellulose Appropriate gelation time, good swelling ability, suitable water evaporation rate, well hemocompatibility, biological compatibility, super absorbent capacity [109] HA and chitosan Treatment of skin ulcers, decreased hydration properties of the dressing and modulation of drug release [82] There are numerous papers reporting preparations of wound dressings composed of three composite wound dressings involving HA biopolymer, e.g., HA, polycaprolactone and encapsulating growth factor [110], HA-povidone-iodine [111], HA, curcumin, pullulan [112], cornstarch/HA/propolis film [113], silk fibroin, HA, sodium alginate composite scaffold [114], HA gel, coenzyme Q10 or vitamin E, benzocaine [115], oxidized HA, vancomycin, adipic acid dihydrazide [116], HA, gelatin, genipin and hinokitiol [117], graphene oxide/copper nanoderivatives-modified chitosan/HA [118], calcium alginate hydrogel loaded with protamine nanoparticles and HA oligosaccharides [119], nanofibrous/gel structure of chitosan-gelatin/chitosan-HA [120], poly dimethylaminoethyl acrylate-HA with Didymocarpus pedicellatus extract hydrogel [121], HA, gelatin and chitosan scaffold [122], HA, silk fibroin, chitosan…”

Section: Components Properties Referencesmentioning

confidence: 99%

Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine

Valachová

Šoltés

2021

IJMS

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Hyaluronan (HA) is a natural glycosaminoglycan present in many tissues of all vertebrates. HA has various biological functions, which are dependent on its molar mass. High-molar-mass HA has anti-angiogenic, immunosuppressive and anti-inflammatory properties, while low-molar-mass HA has opposite effects. HA has also antioxidative properties, however on the other hand it can be readily degraded by reactive oxygen species. For many years it has been used in treatment of osteoarthritis, cosmetics and in ophthalmology. In the last years there has been a growing interest of HA to also be applied in other fields of medicine such as skin wound healing, tissue engineering, dentistry and gene delivery. In this review we summarize information on modes of HA administration, properties and effects of HA in various fields of medicine including recent progress in the investigation of HA.

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Wet-spun bi-component alginate based hydrogel fibers: Development and in-vitro evaluation as a potential moist wound care dressing

Cited by 34 publications

References 35 publications

Development of PVA–Psyllium Husk Meshes via Emulsion Electrospinning: Preparation, Characterization, and Antibacterial Activity

Development of PVA–Psyllium Husk Meshes via Emulsion Electrospinning: Preparation, Characterization, and Antibacterial Activity

Application of Alginate-Based Hydrogels in Hemostasis

Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine

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