Electric power systems are experiencing relevant changes involving the growing penetration of distributed generation and energy storage systems, the introduction of electric vehicles, the management of responsive loads, the proposals for new energy markets and so on. Such an evolution is pushing a paradigm shift that is one of the most important challenges in power network design: the management must move from traditional planning and manual intervention to full âsmartizationâ of medium and low voltage networks. Peculiarities and criticalities of future power distribution networks originate from the complexity of the system which includes both the physical aspects of electric networks and the cyber aspects, like data elaboration, feature extraction, communication, supervision and control; only fully integrated advanced monitoring systems can foster this transition towards network automation. The design and development of such future networks require distinct kinds of expertise in the industrial and information engineering fields. In this context, this paper provides a comprehensive review of current challenges and multidisciplinary interactions in the development of smart distribution networks. The aim of this paper is to discuss, in an integrated and organized manner, the state of the art while focusing on the need for interaction between different disciplines and highlighting how innovative and future-proof outcomes of both research and practice can only emerge from a coordinated design of all the layers in the smart distribution network architecture.