Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extract

Abstract

Generally, Plants have immense potential in the wounds management and treatment.In Chinese herbology, Hibiscus plant is a potent herb and have a good medicinal values but not scientifically approached. The present study aims to investigate the wound healing and antimicrobial activity of ethanolic extract of Hibiscus hirtus Linn.(HH). Wound healing activity was carried out by excision, incision and burn wound models. Antimicrobial activity was determined by cup plate method. Healing rate was assessed from the rate of wound contraction, epithelialization rate, tensile strength, hexosamine and hydroxyproline content. From the obtained results, it was indicated that the wound contraction and increased tensile strength of Hibiscus hirtus extract exhibits potent wound healing capacity. Hexosamine and hydroxyproline expression were also correlative with the pattern of healing observed. Histological observation indicates that the wounds treated with Hibiscus hirtus extract and povidone iodine have reduced scar formation and enhances fibroblast proliferation, angiogenesis, keratinization and epithelialization. The Hibiscus hirtus extract has excellent antimicrobial activity against the various organisms. Wound healing activity of our ethanolic extract of Hibiscus hirtus has shown the good effect which has proved by different physical, histological, biochemical parameters. Significant antimicrobial activity shown may be due to major active constituents present in plant.

Topical Application of Premna integrifolia Linn on Skin Wound Injury in Rats Accelerates the Wound Healing Process: Evidence from In Vitro and In Vivo Experimental Models

“…Herbal medicines can solve the adverse effects, costs, and antimicrobial resistance issues. The antimicrobial activity possessed by the phytoconstituents in herbal extracts may aid in wound healing [ 11 ]. The effectiveness of antimicrobials in wound healing is well-established and reinforces their role in accelerating wound healing with either systemic or topical use [ 10 – 12 ].…”

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“…By maintaining mitochondrial integrity, B. monnieri extract pretreatment modulated the SNP-induced up-regulation of Bax, cytochrome c and caspase 3 expression and a down-regulation of Bcl2 expression, indicating a cytoprotective role for B. monnieri extract against SNP-induced damage 21 . B. monnieri methanolic extract and its isolated constituent bacoside A showed significant woundhealing activity 20 These findings suggest that B. monnieri could be useful in treating human diseases in which free radical production is a major factor.…”

Wound healing Activities of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine water

“…Later, plant extracts of A. polystachyus leaves have also demonstrated with wound healing activities and justified the use of these extracts for S. aureus infected wounds ( Demilew et al, 2018 ). And, Hibiscus hirtus ethanolic extracts also had proven excellent antimicrobial activity towards wound healing activity ( Ravishankar et al, 2018 ).…”