Xuanfei Baidu decoction attenuates intestinal disorders by modulating NF-κB pathway, regulating T cell immunity and improving intestinal flora

Ma, Lin; Zhao, Xin; Liu, Tao; Wang, Yu; Wang, Jiabao; Kong, Lu; Zhao, Qianru; Chen, Yuru; Chen, Lu; Zhang, Han

doi:10.1016/j.phymed.2022.154100

Cited by 26 publications

(16 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20 Furthermore, RPP treatment increased the abundance of Enterorhabdus, which is negatively correlated with changes in intestinal inflammatory cytokines. 21 Thus, RPP could greatly ameliorate gut microbiota dysbiosis in DSS-induced mice. DSS-induced colitis in mice can lead to depressive behavior, which is partially regulated by the microbiota−gut−brain axis.…”

Section: ■ Discussionmentioning

confidence: 99%

“…In addition, Lachnospiraceae NK4A136 group and Clostridium belong to SCFAs-producing bacteria, especially possessing a strong capability for butyrate production, which have the ability to enhance epithelial barrier integrity and inhibit inflammation . Furthermore, RPP treatment increased the abundance of Enterorhabdus , which is negatively correlated with changes in intestinal inflammatory cytokines . Thus, RPP could greatly ameliorate gut microbiota dysbiosis in DSS-induced mice.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rattan Pepper Polysaccharide Regulates DSS-Induced Intestinal Inflammation and Depressive Behavior through Microbiota–Gut–Brain Axis

Chang,

Wang,

Peng

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a chronic and recurrent disease. Increasing evidence suggests a higher incidence of depression in IBD patients compared with the general population, but the underlying mechanism remains uncertain. Rattan pepper polysaccharide (RPP) is an important active ingredient of rattan pepper, yet its effects and mechanisms on intestinal inflammation and depression-like behavior remain largely unknown. This study aims to investigate the ameliorating effect of RPP on dextran sulfate sodium salt (DSS)-induced intestinal inflammation and depression-like behavior as well as to reveal its mechanism.Our results indicate that RPP effectively ameliorated intestinal microbiota imbalance and metabolic disorders of short-chain fatty acids (SCFAs) and bile acids in mice with DSS-induced inflammation, contributing to the recovery of intestinal Th17/Treg homeostasis. Importantly, RPP effectively alleviated brain inflammation caused by intestinal inflammatory factors entering the brain through the blood−brain barrier. This effect may be attributed to the inhibition of the TLR4/NF-κB signaling pathway, which alleviates neuroinflammation, and the activation of the CREB/BDNF signaling pathway, which improves synaptic dysfunction. Therefore, our findings suggest that RPP may play a role in alleviating DSS-induced gut inflammation and depression-like behavior through the microbiota−gut−brain axis.

show abstract

Section: ■ Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rattan Pepper Polysaccharide Regulates DSS-Induced Intestinal Inflammation and Depressive Behavior through Microbiota–Gut–Brain Axis

Chang,

Wang,

Peng

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…In addition, Xuanfei Baidu decoction can also improve weight loss, spleen index, disease activity index, TNF-α level, and colon tissue injury of mice with acute colitis. Further studies have found that its mechanism is related to the inhibition of NF-κB pathway, downregulation of Th1/ Th2 ratio, and remodeling of intestinal immunity [18] .…”

Section: Discussionmentioning

confidence: 99%

Expert Consensus on the clinical application of Xuanfei Baidu granule

Liu¹,

Zhang²,

Wang³

et al. 2023

Acupuncture and Herbal Medicine

View full text Add to dashboard Cite

Xuanfei Baidu granule is an effective prescription for COVID-19, which is modified from classical famous prescriptions. In order to further standardize clinician’s rational use of Xuanfei Baidu granule, enhance clinical efficacy, improve rational medication level, and let it play a more significant role, the frontline clinical experts are invited for discussion on the major functions, usage, adverse reactions, and considerations of Xuanfei Baidu granule to form the consensus. The consensus is that: Xuanfei Baidu granule has the efficacy of promoting the lung and resolving dampness, clearing heat and removing pathogeneses, purging the lung and depoisoning; it can be used for the treatment of patients with mild, moderate, and heavy COVID-19 and other common upper respiratory tract infectious diseases such as influenza; acute tracheitis and bronchitis and community-acquired lower respiratory tract infectious diseases all belong to damp-toxin constraint in the lungs, Xuanfei Baidu granule can relieve cough, expectoration, and other symptoms caused by an acute exacerbation of the chronic obstructive pulmonary disease, with definite clinical efficacy and good safety. According to the principles of evidence-based medicine, this expert consensus will be updated regularly.

show abstract

“…Intestinal microbiota disorder is an important risk factor for UC ( 5 , 6 ). In recent years, increasing evidence has indicated that intestinal flora plays a vital role in the progression of colitis ( 7 – 9 ). Thus, the reshaping of the intestinal microflora is a potential target in UC treatment intervention strategies.…”

Section: Introductionmentioning

confidence: 99%

Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota

et al. 2022

Microbiol Spectr

View full text Add to dashboard Cite

show abstract

Xuanfei Baidu decoction attenuates intestinal disorders by modulating NF-κB pathway, regulating T cell immunity and improving intestinal flora

Cited by 26 publications

References 47 publications

Rattan Pepper Polysaccharide Regulates DSS-Induced Intestinal Inflammation and Depressive Behavior through Microbiota–Gut–Brain Axis

Rattan Pepper Polysaccharide Regulates DSS-Induced Intestinal Inflammation and Depressive Behavior through Microbiota–Gut–Brain Axis

Expert Consensus on the clinical application of Xuanfei Baidu granule

Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota

Contact Info

Product

Resources

About