You can see pain in the eye: Pupillometry as an index of pain intensity under different luminance conditions

Höfle, Marion; Kenntner-Mabiala, Ramona; Pauli, Paul; Alpers, Georg W.

doi:10.1016/j.ijpsycho.2008.06.008

Cited by 51 publications

(41 citation statements)

References 25 publications

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“…Sleegers et al (2015) have shown, for example, that repeated presentations of reverse-colored playing cards (e.g., black two of hearts) lead to a sustained and consistent increase in pupil dilation across dozens of trials. In terms of pupillary response to pain, several studies report a change in pupil size correlated with noxious stimulation and self-reported pain (Ellermeier & Westphal, 1995;Chapman, Oka, Bradshaw, Jacobson, & Donaldson, 1999;Höfle, Kenntner-Mabiala, Pauli, & Alpers, 2008). The pupil dilates in response to pain stimulation, and importantly, appears to diminish when the subjective experience of pain is lessened, for example, through hypnosis (Walter, Lesch, Stöhr, Grünbergre, & GutierrezLobos, 2006) or opioids (Connelly et al, 2014).…”

Section: Pupillometrymentioning

confidence: 99%

“…We have shown that this diminished response to ostracism might also be reflected in the pupil. The pupil can reflect a variety of cognitive and emotional processes, some of which are related to sympathetic nervous system arousal (Bradley et al, 2008) the experience of pain (Ellermeier & Westphal, 1995;Chapman et al, 1999;Höfle et al, 2008;Walter et al, 2006), and diminished pupillary dilation as a function of opioid impact on pain response (Connelly et al, 2014), One alternative line of evidence for the social-physical pain overlap theory is that self-reports of experienced distress as a result of being ostracized often show no effects on mood, i.e., a numbing effect, whereby an absolute interpretation of the results in terms of its scale frequently indicates a neutral state of mind rather than one of emotional distress (Twenge et al, 2003). In both our studies, we find no significant impact of ostracism on mood in terms of a significant decrease towards the lower end of the response-scale.…”

Section: Social-physical Pain Overlap Theorymentioning

confidence: 99%

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The social pain of Cyberball: Decreased pupillary reactivity to exclusion cues

Sleegers

Proulx

Beest

2017

Journal of Experimental Social Psychology

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Section: Pupillometrymentioning

confidence: 99%

Section: Social-physical Pain Overlap Theorymentioning

confidence: 99%

The social pain of Cyberball: Decreased pupillary reactivity to exclusion cues

Sleegers

Proulx

Beest

2017

Journal of Experimental Social Psychology

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“…The Fp(t) in (9) and Fs(t) in (10) are the muscle forces originated from the parasympathetic and sympathetic system induced by a light stimulus, respectively. These are effective forces that could be affected by both the afferent and efferent pupillary pathway.…”

Section: Implementation Of the Modelmentioning

confidence: 99%

“…Since pupillary dilation is regulated autonomically, an effort was made to use this method as a valid measure of pain [6][7][8][9][10]. Research using pupillometry is being carried out to assess alertness of hypersomnolent patients.…”

Section: Introductionmentioning

confidence: 99%

Rheological model of dynamic pupillary reflex in the assessment of the level of autonomic nervous system activation

Różanowski¹,

Truszczyński²,

Lewandowski³

et al. 2016

WIT Transactions on Engineering Sciences

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The aim of this publication was to adapt a rheological model of Kelvin-Voigt in the description of the dynamic pupillary reflex. The pupillary reflex presents the results of physiological adaptation mechanisms in the human eye, i.e. response of the iris to the changing intensity of light falling on the retina under the condition of sensory deprivation. Pupillary light reflex (PLR) is a closed loop nerve reflex.The new approach to PLR evaluation presented by the authors consists of adapting the Kelvin-Voigt model to the description of this phenomenon. The authors, for their tests of correct implementation of the model, used data from pilot studies. Research was performed on a group of 10 volunteers in a laboratory environment, at night. The mean age of the study participants was 27 ± 0.4 years. For PLR registration, the F²D Fit-For-Duty system was used .The system provides useful data for shift work or for personnel in high-risk careers.The PLR measurements were taken for both eyes, which were exposed to a series of five flashes at 30-second intervals. The whole measurement of both eyes was conducted with patients wearing goggles, in order to maintain the same measurement conditions, mostly with regard to accommodation.Owing to proper implementation of the model, we managed to attain a high level of its adaptation to real data (>90%). The results show their strong correlation, and the model shows high sensitivity to changes in the shape of the reflex curve, caused by sleep deprivation introduced in the experiment.

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“…The F²D recording of spontaneous and involuntary pupil movements in the darkness is the simplest method to objectively measure and evaluate the level of sleepiness. The system includes infrared goggles, which are dilation is regulated autonomically, an effort was made to use this method as a valid measure of pain [13]. Research using pupillometry is being carried out to assess alertness in hypersomnolent patients.…”

Section: Experimental Designmentioning

confidence: 99%

Estimation of operators’ fatigue using optical methods for determination of pupil activity

Różanowski

Bernat

Kamińska

2015

Int J Occup Med Environ Health

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Objectives: The purpose of this study was to develop and initially validate an objective, yet quick, method for assessment of human fatigue. This aim can be achieved by the use of an optical, non-contact method of analysis of pupil activity. The study involved 2 phenomena typical for the behavior of the human pupil: pupillary reflex and pupillary movements. The 1st phenomenon is related to the pupillary light reflex (PLR), which presents the results of physiological adaptation mechanisms of the human eye. The pupillary unrest index (PUI) is an additional parameter referring to the tendency for instability of the pupil. Material and Methods: Indicators of these 2 mechanisms were assessed under the same experimental laboratory conditions. Assessment was conducted on a group of volunteers (N = 10) during 4 controlled series of measurements performed at night. Pupillary reflex parameters associated with PLR and pupillary unrest index (PUI) were recorded using F²D Fit-For-Duty, a commercially available system made by AMTech Pupilknowlogy GmbH. Baseline pupil diameter, oscillations, reflex latency, maximum reaction time, pupil constriction time, pupil dilation time, and constriction amplitude were recorded. Results: As a result of the study, we were able to demonstrate correlation and confirm the usefulness of PLR and PST methods in the assessment of sleep deprivation. Parameters of PLR that may indicate human fatigue were identified. The effect of light impulse sequences on the dynamics of pupillary reflex and the relationship between PUI (pupillary unrest index) measurement duration and sleepiness assessment validity, were assessed. Conclusions: The results of the pilot studies were sufficient to develop minimum requirements for a PLR sensor that would be capable of estimating the level of fatigue with accuracy of a PUI method, but at a 5 times faster rate.

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You can see pain in the eye: Pupillometry as an index of pain intensity under different luminance conditions

Cited by 51 publications

References 25 publications

The social pain of Cyberball: Decreased pupillary reactivity to exclusion cues

The social pain of Cyberball: Decreased pupillary reactivity to exclusion cues

Rheological model of dynamic pupillary reflex in the assessment of the level of autonomic nervous system activation

Estimation of operators’ fatigue using optical methods for determination of pupil activity

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