“…There are several cases where ascorbate has been implicated in hydroxylation reactions. Thus the hydroxylating processes required in the biosynthesis of corticosteroids are ascorbate-dependent (Hofmann & Staudinger, 1951;Kahnt & Wettstein, 1951;Staudinger, 1958;Kernsten, Leonhauser & Staudinger, 1958). Ascorbate is also known to participate in the formation of 5-hydroxytryptophan from tryptophan (Cooper, 1961), and of hydroxyproline from proline (Stone & Meister, 1962).…”