Zur Frage der Synthese von Vitamin A

Karrer, P.; Rüegger, A.

doi:10.1002/hlca.19400230135

Cited by 23 publications

(5 citation statements)

References 1 publication

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“…Several unsuccessful attempts were made to repeat the Kuhn synthesis. [163,164] It would be another ten years before vitamin A was synthesized again, although the outbreak of the Second World War almost certainly interfered with progress. The key building block for the synthesis by Kuhn and Morris, as well as all future vitamin A syntheses, is b-ionone (60).…”

Section: First Synthesis Of Vitamin Amentioning

confidence: 99%

One Hundred Years of Vitamins—A Success Story of the Natural Sciences

Eggersdorfer¹,

Laudert²,

Létinois³

et al. 2012

Angew Chem Int Ed

265

209

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The discovery of vitamins as essential factors in the diet was a scientific breakthrough that changed the world. Diseases such as scurvy, rickets, beriberi, and pellagra were recognized to be curable with an adequate diet. These diseases had been prevalent for thousands of years and had a dramatic impact on societies as well as on economic development. This Review highlights the key achievements in the development of industrial processes for the manufacture of eight of the 13 vitamins.

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Section: First Synthesis Of Vitamin Amentioning

confidence: 99%

One Hundred Years of Vitamins—A Success Story of the Natural Sciences

Eggersdorfer¹,

Laudert²,

Létinois³

et al. 2012

Angew Chem Int Ed

265

209

View full text Add to dashboard Cite

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“…The preparation by Kuhn and Morris could not be repeated by other vitamin A scientists. − Two years later in 1939, Lipping and Wild reported the synthesis of vitamin A methyl ether . A detailed procedure and analysis of intermediates or products were never published.…”

Section: Development Of the First Laboratory Synthesismentioning

confidence: 99%

75 Years of Vitamin A Production: A Historical and Scientific Overview of the Development of New Methodologies in Chemistry, Formulation, and Biotechnology

Bonrath,

Gao,

Houston

et al. 2023

Org. Process Res. Dev.

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In 1948, the first kilograms of synthetic vitamin A (acetate) were produced by F. Hoffmann-La Roche, eliminating the need to extract this vital compound from natural sources; this year marks 75 years of successful production. Since then, a number of chemical routes have been commercialized. Of these, three processes have stood the test of time and are still in use today, with only minor modifications. This review covers both the historical and scientific developments in the production of vitamin A derivatives from their beginnings up until recent developments including a fully catalytic process and the successful pilot-scale production via fermentation. In addition, the development of formulation technologies, which have gone hand-in-hand with chemical process development, is described; correct formulation is essential for stabilizing vitamin A derivatives which are sensitive to light and oxidation.

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“…Dies war die bevorzugte Produktionsmethode in den 1930er-und 1940er Jahren. [163,164] Es dauerte weitere zehn Jahre, bevor Vitamin A erneut synthetisiert wurde, auch wenn sicherlich berücksichtigt werden muss, dass der Ausbruch des Zweiten Weltkriegs Auswirkungen auf den Fortschritt hatte. Über die erste Synthese von Vitamin A berichteten Kuhn und Morris 1937 (Schema 30).…”

Section: Erste Synthese Von Vitamin Aunclassified

“…Es gab indes mehrere erfolglose Versuche, die Kuhnsche Synthese zu wiederholen. [163,164] Es dauerte weitere zehn Jahre, bevor Vitamin A erneut synthetisiert wurde, auch wenn sicherlich berücksichtigt werden muss, dass der Ausbruch des Zweiten Weltkriegs Auswirkungen auf den Fortschritt hatte. Der Schlüsselbaustein für die Synthese nach Kuhn und Morris sowie auch für alle nachfolgenden Vitamin-A-Synthesen ist b-Ionon (60).…”

Section: Erste Synthese Von Vitamin Aunclassified

Einhundert Jahre Vitamine – eine naturwissenschaftliche Erfolgsgeschichte

et al. 2012

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Die Entdeckung der Vitamine als lebenswichtige Verbindungen in der Nahrung vor 100 Jahren stellte einen wissenschaftlichen Durchbruch dar, der die Welt veränderte. Die Erkenntnis, dass sich früher weit verbreitete Krankheiten wie Skorbut, Pellagra, Rachitis und Beriberi durch eine ausgewogene Ernährung vermeiden oder heilen lassen, hatte einschneidende Auswirkungen auf Gesellschaft und wirtschaftliche Entwicklung. Dieser Aufsatz fasst Schlüsselerfolge in Entwicklung und industrieller Herstellung von acht der insgesamt dreizehn Vitamine zusammen.

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Zur Frage der Synthese von Vitamin A

Cited by 23 publications

References 1 publication

One Hundred Years of Vitamins—A Success Story of the Natural Sciences

One Hundred Years of Vitamins—A Success Story of the Natural Sciences

75 Years of Vitamin A Production: A Historical and Scientific Overview of the Development of New Methodologies in Chemistry, Formulation, and Biotechnology

Einhundert Jahre Vitamine – eine naturwissenschaftliche Erfolgsgeschichte

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