α-Adrenergic Drugs in Retrograde Ejaculation

A New Theory of Micturition and Urinary Continence Based on Histomorphological Studies

“…Other authors speak at least of a sealing of the ejaculatory ducts by the dorsal longitudinal urethral muscle system during micturition [6], Homsy [7] declines an involve ment of the urethral crest in both processes. In the func tional respect, examinations seem to be interesting when, by means of stimulation of nerves having a function of the coordination of the sexual function, they had shown that in the process of emission of semen there is a contraction of the sphincter vesicae and of the longitudinal urethral muscle system, respectively [8][9][10], …”

The Use of Midodrin in the Treatment of Ejaculation Disorders following Retroperitoneal Lymphadenectomy

“…At the same time the bladder neck contracts so as to occlude the pros tatic urethra proximal to the bladder. In the sec ond phase of ejaculation; rhythmic contractions of the muscles of the pelvic floor are initiated by the pudendal nerve and semen is expelled into the anterior urethra and ejaculated into the external urinary meatus (2,7,9,11,12).…”

“…The long-term treatment of retrograde ejaculation disorders following retroperitoneal lymph adenectomy with the a-sympathomimetic, Midodrin, administered orally, led to improvements in the intensity of orgasm and the degree of erection. Normal ejaculation was induced in 7 out of 12 patients and emission of spermatozoa into the posterior urethra was restored in 3 out of 12 patients by a single intravenous injection of 25-30 mg Midodrin.for malignant tumours of the testis; spinal cord injuries; diabetic neuropathy, and the use of aadrenergic blockers such as phenoxybenzamine (7,11). …”

Diagnostic and treatment of retrograde ejaculation as a manifestation of urogenital form of autonomic diabetic polyneuropathy

“…Консервативная терапия РЭ может включать приме-нение антигистаминных препаратов (бромфенирамин), трициклических антидепрессантов (имипрамин) и других средств, в том числе антихолинергических и адренергиче-ских агентов [8][9][10][11]. Afara и El Tabie (2008) в своем иссле-довании получили данные относительно эффективности в отношении восстановления антеградной эякуля ции при применении имипрамина у 38% и эфедрина у 48% мужчин с РЭ вследствие СД, а также комбинации обоих препаратов в 61,5% случаев.…”