α-Amylase inhibitory effect of 3β-olean-12-en-3-yl (9Z)-hexadec-9-enoate isolated from Spondias mombin leaf

Fred-Jaiyesimi, Adediwura A.; Kio, Abo; Richard, W. Allmendinger

doi:10.1016/j.foodchem.2009.02.047

Cited by 61 publications

(30 citation statements)

References 13 publications

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“…56 By analysing the leaves of this species, Corthout and et al 57 identified the presence of two ellagitannins, which was attributed to antiviral activity, effective against dengue type 2. Several other authors also corroborate the results found in the analysis performed in this study, stating the presence hydrolyzable tannins.…”

Section: 35mentioning

confidence: 99%

Pharmacognostic Characterization of Spondias mombin L. (Anacardiaceae)

Vasconcelos¹,

Vasconcelos²,

Randau³

2016

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Background: Spondias mombin L. is fruit specie found in Tropical America and the coast of Africa, popularly known as cajazeira. Several researches with extract of leaflets show a diversity of promising pharmacological activities such as antibacterial activity, antiviral against dengue virus type 2, anti diabetic, among others. Objective: This paper aims to study the anatomical characteristics, phytochemical and histochemical from leaves of this species. Materials and Methods: Cross and paradermic sections from leaves were submitted to double staining with astra blue and safranin process for the anatomical study. Anatomical analysis of the structures was performed using an optical microscope. For ultra structure analysis, the leaf fragments, after processing and gold coating, were observed under scanning electron microscopy (SEM). The phytochemical analyses were performed using thin layer chromatography and the histochemical analyses using specific reagents for each metabolite group. Results: The leaf has anomocytic and tetracytic stomata distributed on abaxial surface. The midrib has convex symmetry with collateral vascular bundles in a closed arc disposition. The phytochemical showed the presence of mono and sesquiterpenes, triterpenes and steroids, hydrolysable tannins, phenylpropanoid glycosides, cinnamic derivatives and flavonoids. The histochemical tests allow us to state that phenolic compounds are found in the palisade parenchyma cells. Lignins can be found in woody vascular bundles and in perivascular sclerenchyma fibres. The volatile oils were evidenced in the schizogenous cavity, present in the parenchyma of the midrib. Conclusion: The results allowed characterizing anatomically the leaves of this species, outlining a profile of its phytochemical constituents and, in addition, determining which anatomical structures of storage of these metabolites by the plant.

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Section: 35mentioning

confidence: 99%

Pharmacognostic Characterization of Spondias mombin L. (Anacardiaceae)

Vasconcelos¹,

Vasconcelos²,

Randau³

2016

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“…Plant derived natural extracts contain a wide variety of pancreatic a-amylase inhibitors which are of therapeutic importance as oral hypoglycemic agents in diabetes mellitus (Fred-Jaiyesimi, Kio, & Richard, 2009;Sudha, Zinjarde, Bhargava, & RaviKumar, 2011;Tundis, Loizzo, & Menichini, 2010). The chemical diversity of these components present in extracts has tremendous potential for the discovery of new molecules with pharmacological activity.…”

Section: Introductionmentioning

confidence: 99%

Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes

et al. 2012

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“…mombin. (Fred-Jaiyesimi et al, 2009;Olugbuyiro et al, 2013). Glucose lowering assay Stigmasta-9-en-3,6,7 triol and 3-hydroxy,22epoxystigmastane.…”

Section: Introductionmentioning

confidence: 99%

“…The various uses of the leaves, stem bark and fruits of Spondias mombin L in folk medicine for the treatment of ailments and diseases have been reported (Ayoka et al 2005;Ayoka et al, 2006) while some of these folk uses have been investigated. The antidiabetic and hypoglyceamic effects of the leaves (Fred-Jaiyesimi and Abo, 2009), seed (Iweala et al, 2011), hypolipidemic and antioxidant activity of the leaves (Nkanu et al, 2016) have been reported. Also, the extract of the leaves of S. mombin has been shown to have the ability to reduce labour times and treat hemorrhage (Pakoussi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Glucose lowering activities of mombintane I and mombintane II isolated from the leaves of Spondias mombin L

Fred-Jaiyesimi¹,

Wilkins²,

Abo³

2017

Int. J. Bio. Chem. Sci

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The uses of Spondias mombin Linn in folk medicine as part of recipe for the management and treatment of Diabetes mellitus are well documented. This has been investigated and proven using various experimental models. The aim of this study was to report two isolated compounds from S. mombin leaves probably exhibiting synergistic glucose lowering effects in the in vitro model. The in vitro α-amylase inhibitory assay was used to establish the glucose lowering activities of the isolated compounds while, the isolated compounds were determined from the spectra of their MS, IR and proton NMR. It was established that they are sterols with molecular formula C 29 H 52 O 2 and C 29 H 50 O. The two compounds exhibited a synergistic effect of 61% αamylase inhibitory activity. This study shows that mombintane I and mombintane II exhibit synergistic effect in lowering blood glucose levels.

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α-Amylase inhibitory effect of 3β-olean-12-en-3-yl (9Z)-hexadec-9-enoate isolated from Spondias mombin leaf

Cited by 61 publications

References 13 publications

Pharmacognostic Characterization of Spondias mombin L. (Anacardiaceae)

Pharmacognostic Characterization of Spondias mombin L. (Anacardiaceae)

Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes

Glucose lowering activities of mombintane I and mombintane II isolated from the leaves of Spondias mombin L

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