Роль І Місце Альбуміну В Сучасній Інфузійно-Трансфузійній Терапії

Cherniy, V.І.

doi:10.22141/2224-0586.1.80.2017.94448

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Therefore, the pathogenetic components of the treatment of these diseases are antibiotic therapy and infusion therapy with albumin solutions to replenish the amount of complete albumin in BS. According to the latest International Guidelines for the treatment of severe sepsis and septic shock, experts propose to use albumin in large volumes for infusion-transfusion therapy[18] [19] [20][21].…”

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confidence: 99%

Diagnostic and Therapeutic Model of Sepsis and Purulent-Inflammatory Diseases

Ostapiuk¹

2019

IJCM

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In this study, the method of fluorescence spectroscopy was used to improve the diagnostics and prediction of sepsis, pyo-inflammatory diseases and postpartum endometritis. At the first stage of the study, the researcher explored the fluorescence spectra of dilutions of serum with centrifuged and non-centrifuged bacterial culture (6-day crop sugar broth with Staphylococcus aureus), distilled water, 20% albumin and sugar broth. The focus was on the influence of treatment, including infusion therapy, on the fluorescence spectral characteristics of a patient's serum. At the second stage, the method of fluorescence spectroscopy was used for the diagnosis of sepsis in vivo. At the third stage, the analyst scrutinized the peculiarities of pregnancy, childbirth, and the postpartum period (totally, 40 parameters) in patients with postpartum pyo-inflammatory diseases and in the control group.

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confidence: 99%

Diagnostic and Therapeutic Model of Sepsis and Purulent-Inflammatory Diseases

Ostapiuk¹

2019

IJCM

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“…HSA binds paclitaxel with a binding constant of 1.43 × 104 M −1 [ 29 ]. The plasma albumin concentration normally ranges from 35 to 50 g/L [ 30 ], and 60% of the albumin is located in the interstitial and intracellular space [ 31 ]. Thus, HAS could be considered as a potential candidate as a PTX transporter in PBS but not in BP.…”

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confidence: 99%

Influence of Elongation of Paclitaxel-Eluting Electrospun-Produced Stent Coating on Paclitaxel Release and Transport through the Arterial Wall after Stenting

et al. 2021

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It was previously shown that polycaprolactone (PCL)-based electrospun-produced paclitaxel (PTX)-enriched matrices exhibit long-term drug release kinetics and can be used as coatings for drug-eluting stents (DES). The installation of vascular stents involves a twofold increase in stent diameter and, therefore, an elongation of the matrices covering the stents, as well as the arterial wall in a stented area. We studied the influence of matrix elongation on its structure and PTX release using three different electrospun-produced matrices. The data obtained demonstrate that matrix elongation during stent installation does not lead to fiber breaks and does not interfere with the kinetics of PTX release. To study PTX diffusion through the expanded artery wall, stents coated with 5%PCL/10%HSA/3%DMSO/PTX and containing tritium-labeled PTX were installed into the freshly obtained iliac artery of a rabbit. The PTX passing through the artery wall was quantified using a scintillator β-counter. The artery retained the PTX and decreased its release from the coating. The retention of PTX by the arterial wall was more efficient when incubated in blood plasma in comparison with PBS. The retention/accumulation of PTX by the arterial wall provides a prolonged drug release and allows for the reduction in the dose of the drugs in electrospun-produced stent coatings.

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Prognostic informativeness of functional activity and serum albumin concentration in patients in chronic critical illness with different disease outcomes

Parfenov

Petrova

Kiryachkov

et al. 2020

Mediko-farmacevtičeskij žurnal "Pulʹs"

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The outcome in a chronic critical illness (CCI) after cerebral catastrophes occurs in 5-10% of patients in intensive care units and is accompanied by severe homeostasis disorders with a likely outcome in multiple organ failure. In this aspect there is a need for a deep study of the pathogenesis of a CCI with the identification of the most significant outcome criteria Purpose of the study: To reveal the prognostic in formativeness of functional activity and serum albumin concentration in patients in a CCI with different disease outcomes. Materials and methods: A comparative retrospective study was carried out of the concentration and functional activity (detoxifine efficiency - DTE) of serum albumin in 19 deceased (Group1) and 38 survived patients (Group 2) after cerebral catastrophic injury resulting in CCI. Samples for the study were obtained at the admission of patients, in the middle of the treatment and before discharge of patients. Results: It was established that in Group 1 the average value of albumin concentration and DTE decreased significantly, while in Group 2 values increased from the moment of admission to the discharge of patients. A ROC-analysis demonstrated a sufficiently high diagnostic informativeness of albumin DTE and concentration criteria, that differed in patients of Group 1 and 2 throughout all phases of the study. Conclusions: The outcome to a CCI after cerebral catastrophes is accompanied by changes in the concentration of serum albumin and violations of its functional activity – DTE. In patients with a fatal outcome, in contrast to patients with a positive effect of treatment, there is a progressive decrease in the concentration of serum albumin, which is combined with a pronounced decrease in its functional activity

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Роль І Місце Альбуміну В Сучасній Інфузійно-Трансфузійній Терапії

Cited by 4 publications

References 10 publications

Diagnostic and Therapeutic Model of Sepsis and Purulent-Inflammatory Diseases

Diagnostic and Therapeutic Model of Sepsis and Purulent-Inflammatory Diseases

Influence of Elongation of Paclitaxel-Eluting Electrospun-Produced Stent Coating on Paclitaxel Release and Transport through the Arterial Wall after Stenting

Prognostic informativeness of functional activity and serum albumin concentration in patients in chronic critical illness with different disease outcomes

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