The article provides a detailed analysis of the educational complex in the discipline "Outpatient therapy", which is taught at the relevant departments of RNIMU named after N.I. Pirogov and the department of the same name VSMU named after N.N. Burdenko. Both of these universities are part of the East European NOMK, which was created to implement the Strategy for the Development of Medical Science in the Russian Federation for the period until 2025. The fundamental difference between the educational process in the two universities is the different distribution of the hourly load across semesters and the methodological approach to studying the discipline. Various approaches to teaching discipline in universities are aimed at achieving a common goal - the training of medical personnel focused on achievement of a common goal - the training of medical personnel oriented to the professional standard “Physician-general practitioner (district general practitioner)” and the provision of primary health care. The experience accumulated by the staff of the departments allows us to fully approach the training of specialists and, quite justifiably, to begin interaction between structures for the exchange of this experience.

The results of gas discharge visualization method of expired air condensate in children and teenagers with diabetes 1 have been presented. 8 healthy (average age is 12,13±2,23) and 9 sick children (average age is (14,4±2,13) were examined. Lipodystrophy and diabetic polyneuropathy have been detected among all patients. Glucose level in blood plasma was equal to 9,64±1,08 mM/g, haemoglobin (НbА1с) – 9,62±0,67%. Change of some gas discharge visualization parameters (light emission area increase, normalized area, entropy of isometric line, midradius of isometric line, normalized standard deviation, isometric line radius and length) have been observed in patients with diabetes. These changes reflect peculiarities of functional changes at diabetes 1 so bioelectrography may be used in ambulance conditions as diagnostic method.

The high incidence of stable coronary heart disease, the increasing frequency of myocardial infarction, disability and mortality determine the relevance of the search for new risk markers and laboratory criteria for predicting this severe complication. The aim of the study was to develop an information panel for diagnosing the risk of myocardial infarction in patients with stable coronary heart disease, including significant generally accepted and potentially possible new laboratory parameters characterizing various pathogenetic links of coronary atherosclerosis. The study included 168 patients who were divided into 2 groups: Group 1 - with a history of myocardial infarction, Group 2 - without a history of myocardial infarction. In addition to the standard laboratory and instrumental examination, all patients were identified parameters of endothelial dysfunction, oxidative stress and chaperone activity as potential markers of myocardial infarction in patients with stable coronary heart disease. Assessment of the risk of myocardial infarction in patients with stable coronary heart disease was carried out using a logical and mathematical model, which combined the most informative laboratory indicators of oxidative stress, endothelial dysfunction, and chaperone activity, which are important in the occurrence and progression of coronary atherosclerosis, according to the results of preliminary comparative and correlation analysis. The basis for the development of the information panel was the method of decision trees. The study confirmed the relationship between the severity of coronary atherosclerosis and the occurrence of myocardial infarction. Comparative analysis of the selected groups of patients showed a higher level of oxidative stress, serum homocysteine concentrations and lower values of chaperone activity in Group 1. In patients with a history of myocardial infarction, C-reactive protein was significantly higher than in Group 2, indicating a more pronounced inflammatory response in patients with large atherosclerotic lesions. The study suggests the possibility of using mathematical information panels based on decision trees as a system for assessing the risk of acute myocardial infarction in patients with stable coronary heart disease. As a result of the analysis of the obtained model, laboratory biochemical factors of high risk of myocardial infarction were identified. Such factors were chaperone activity, serum homocysteine level, serum C-reactive protein concentration and superoxide dismutase activity.

The prevalence of risk factors for cardiovascular diseases and the electrophysiological state of the myocardium in male patients with somatoform dysfunction of the vegetative nervous system was studied. Among the risk factors, the leading positions were taken by stress, low physical activity and smoking. A method has been developed for diagnosing prenosological changes in the electrophysiological state of the myocardium associated with the tension of the regulatory systems in male patients with somatoform dysfunction of the vegetative nervous system in order to identify prenosological conditions and increased risk of the cardiovascular disease. The correlation between the sum of points according to the developed method and indicators characterizing the state of the sympathetic section of the vegetative nervous system and the electrophysiological state of the myocardium have been proved. The threshold score for risk factors for the cardiovascular disease, corresponding to the presence of prenosological changes in the electrophysiological state of the myocardium in male patients with somatoform dysfunction of the vegetative nervous system is 8. The diagnostic sensitivity of the method in male patients with somatoform dysfunction of the vegetative nervous system with a threshold score of 8 was 80 %, specificity-70.8 %.

The article handels the problem of using the methods of encouragement and punishment as a means of socializing adolescents with deviant behavior. Faced with various difficulties, a teenager may experience difficulties in the process of assimilation and reproduction of social experience that make up the essence of socialization. Against the background of objective difficulties in the process of following social norms, this category of children is faced with a variable pedagogical impact. The main objective of the study was to identify the existing differences in the perception of the effectiveness of the methods of promotion and punishment as means of socialization in adolescents (as objects of education) and teachers (as subjects of education). Materials and research methods In order to identify among teachers, their preferred forms of encouragement or punishment when working with deviant adolescents, at the first stage of the study, we used an author's questionnaire for teachers, which included questions about the teaching experience most often used in working with deviant teenagers of forms of encouragement and punishment, on the effectiveness of using methods of encouragement and punishment with this category of children. In addition, within the framework of this questionnaire, teachers had the opportunity to express a subjective opinion on the advisability of including in the educational process the missing forms of encouragement and punishment. The research sample included 7 teachers, carried out by class teachers in grades 7–9 of educational institutions in Kolomna, Moscow Region. Results of the study Our study allows us to conclude that in most cases the expectations of children associated with receiving the desired promotion are not met, which in turn can subsequently form a negative attitude of the teenager towards the teacher, as well as a decrease in motivation in the performance of a task. In addition, we have identified significant differences between the applied teachers and preferred forms of punishment by children. So, for example, if educators consider the most effective form of punishment as public censure, then children, on the contrary, prefer loyal methods of punishment, talking about such forms as remarking and removal from fulfilling responsible assignments, arguing that public punishment degrades the dignity of the child and causes even greater aggression and a desire to do “everything against”. An interesting fact is that the teachers are against such a form of punishment as “removal from the class”, although the students themselves are not at all against such a measure, explaining this by saying that if the child interferes with the lesson, then he must leave the class.