The present in vitro study evaluated the recurrence rate of caries following cavity preparations with bur (conventional technique) and irradiation by Erbium:Yttrium- Aluminum-Garnet (Er:YAG) laser through micro hardness test. A total of 72 human extracted molars were randomly divided into 3 groups and class 5 cavities were prepared on them with 3 different methods: G1) conventional bur, G2) Er:YAG laser irradiation alone and G3) laser irradiation + laser treatment. The specimens were immersed in the artificial caries solution with pH of 2.0 and 5.0 (12 days) and then immersed in re-mineralizing solution with pH of 7.0 (25 days). The specimens were longitudinally sectioned and their Vickers micro hardness was determined. Data were statistically analyzed by means of three-way analysis of variance (ANOVA) and Tukey multiple comparisons tests. The micro hardness of the samples was affected by substrate type (enamel and dentin) and low values were achieved in dentin (<0.001). Moreover, no significant difference was observed between preparation methods by bar and laser irradiation alone ( ≤0.499). Although laser irradiation + laser treatment decreased micro hardness of enamel compared to other methods. In dentin samples, different methods of preparation showed no significant effect on micro hardness ( ≤0.874). Due to the similar values of micro hardness following G1 and G2, it seems that Er:YAG laser alone is as much effective as the conventional bur to prevent recurrence caries. However, because of the high prices of laser instruments, bur preparations can be done commonly.

Background: Acute leukemia is a malignant, rapidly progressive disease of the bone marrow and blood that most commonly occurs in children. Abnormalities of blood caused by leukemia and also accumulation of leukemic cells in different parts of the oral cavity cause a wide spectrum of oral manifestations. Objectives: The current study aimed to estimate the incidence of leukemia among children in Tehran and evaluate oral manifestations of the disease as potential diagnostic markers. Patients and Methods: In this retrospective cross-sectional study, medical records of children younger than 12 years referred to Mofid hospital, Ali-Asghar hospital and Children's medical center from 1997to 2011 were retrieved from the hospital archives and evaluated. Records of 100 patients with leukemia were randomly selected for evaluation. The obtained data were transferred to the questionnaires. Data were analyzed using SPSS version 11.5 and Chi-square test. Results: Of the 3,789 children younger than 12 years referred to the hematology department of Tehran pediatric hospitals from 1997 to 2001, 1,372 had acute leukemia, put of which 94% had acute lymphoblastic leukemia and 5% had acute myeloid leukemia. Boys aged 5 -10 years made up 69% of the acute leukemia cases. The most common oral manifestation was gingival bleeding and petechiae. The most important disease other than leukemia was anemia in the patients. Conclusions:The present study highlights the role of dentists to detect oral manifestations of leukemia and their possible role in early diagnosis of patients with the disease.

Background and Aim Periostin acts as necessary protein in tissue development and has a key role in tooth-supporting tissues such as periodontal ligament. The effect of inflammation on reducing periostin level has been shown in some studies. The aim of this study was to compare the salivary and Gingival Crevicular Fluid (GCF) periostin levels in patients with chronic periodontitis and healthy peers. Methods & Materials In this matched case-control study, 106 participants (53 patients with chronic periodontitis and 53 healthy controls) were studies after signing a informed consent form. They were matched for age, gender, weight, and Body Mass Index (BMI). The GCF and salivary samples were collected from all participants and were assessed using standard Enzyme-Linked Immunosorbent Assay (ELISA). The statistical analysis was conducted in Stata V. 11. Ethical Considerations This study was approved by the Research Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1397.34). Results The salivary and GCF periostin levels was significantly lower in patients than in healthy subjects (P<0.001). Moreover, the periostin levels was significantly different based on periodontal parameters (P<0.001). Conclusion There is association between the incidence of chronic periodontitis and salivary and GCF periostin levels. Hence, the periostin may act as a potential biomarker for the diagnosis of chronic periodontitis and prevention of its progression.

Aim: Pain is one of the clinical problems after orofacial surgeries. There have been various studies about the analgesic effect of nonsteroidal antiinflammatory drugs (NSAIDs) in this group of surgeries. In recent years, meloxicam has undergone clinical trials in dentistry. The purpose of this study was to review the efficacy of meloxicam on postoperative pain in dentistry. Materials and methods: The study design was in accordance with the PRISMA guidance. The keywords according to MeSH and related articles were searched in the EBSCO, MEDLINE (via Ovid), PubMed, Science Direct, Scopus, Web of Science and Google Scholar databases. Then eligible randomized clinical trials articles, which released up to December 2017, were thoroughly reviewed. Results: The nine eligible articles were studied. Meloxicam was administered with doses of 7.5, 10 and 15 mg (oral or intramuscular) before or after the third molar extraction. Meloxicam has a similar or significantly better analgesic effect than some of the selective and nonselective NSAIDs and significantly has a better analgesic effect than some of salicylic acids and tramadol. Conclusion: Meloxicam can be considered as an alternative analgesic agent than some NSAIDs, tramadol and salicylic acids in patients who have undergone the third molar extraction.The best way to pain intensity control following orofacial surgeries has not yet been introduced. According to a common rule, non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen or their combination are the most prescribed items for of pain intensity control after orofacial surgery 6,7 .Up to now, many studies have been conducted to evaluate the effectiveness of different analgesic drugs, including opioids, corticosteroids, salicylic acids and NSAIDs in dentistry. Generally, selective cyclooxygenase-2 (COX-2) inhibitor NSAIDs may be preferred over their non-selective ones in terms of pain intensity control and a decrease in additional Oral Surgery 13 (2020) 188--196.

Background and Aim Periodontal diseases are among the most prevalent inflammatory diseases caused by oral bacteria. Expansion of oral biofilm causes various diseases such as gingival inflammation and periodontitis. The Satureja plant has various species, all of which are aromatic. This plant is traditionally used for the treatment of some diseases. The present study was conducted to evaluate the effect of Satureja essential oil on periodontal pathogens. Methods and Materials In this study, we evaluated four pathogens; Enterococcus faecalis, Streptococcus sanguinis, Eikenella corrodens, and Actinomyces viscosus. We also used the disk diffusion test and broth microdilution method to evaluate the antimicrobial effect of Satureja essential oil. Finally, we determined the minimum inhibitory concentration and minimum bactericidal concentration. Ethical Considerations The Ethics Committee of Arak University of Medical Sciences approved this study (Code: IR.ARAKMU.REC.1397.67). Results In concentration of 0.1 g/mL of Satureja plant, Actinomyces viscosus, Streptococcus sanguinis, Enterococcus faecalis, and Eikenella corrodens were found to be sensible to resistance. The Satureja essential oil had the highest effect on Eikenella corrodens. Results obtained from the biofilm test showed no biofilm in a concentration of 12.5 mg/mL and higher of Satureja plant. Conclusion The Satureja plant was found to have an antibacterial and inhibitory effect on biofilm growth and formation in the oral cavity.