The purpose of this study was to detect elevated uric acid level in maternal blood, presumably due to decrease renal urate excretion, for early detection of hypertensive disorder in pregnancy. This study showed that serum uric acid was significantly elevated in all cases of preeclampsia. The present study showed that serum uric acid levels were significantly elevated in eclampsia as compared with the levels in pregnancies complicated by hypertension (p<0.05). The level of uric acid above 4.5 mg/dl is indicative of preeclamptic process and in such cases; the subjects deserve careful and close clinical follow up. Increasing higher concentration of uric acid i.e. 5.7 mg/dl, 6.3mg/dl, and 6.72mg/dl was observed in pregnancy with chronic hypertension, preeclampsia and eclampsia respectively. These results showed that serum uric acid could be used as a sensitive indicator of severity of preeclampsia. Out of 100 cases, there were 20 preterm baby and others such as stillbirth and IUD. So, these entire abnormal fetal outcomes were in the hyperuricaemic group and 5.37 times higher as compared to low serum uric acid group. Mean birth weight of preeclampsia and eclampsia were 2.31kg and 2.30kg respectively compared with 2.5kg in chronic hypertension group.

Background: Patients with right ventricular infarction is a critical condition and may cause adverse cardiac events. Objective: The purpose of the present study was to compare the in-hospital complications among patients with right ventricular infarction based on TIMI risk score. Methodology: This prospective observational study was conducted in the Department of Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh from May 2007 to April 2008 for a period of one year. All the patients who were admitted into the coronary care unit of NICVD with acute inferior myocardial infarction with or without anterior myocardial infarction were selected as study population. Inclusion Criteria were patients admitted in CCU (NICVD) with acute inferior myocardial infarction with right ventricular infarction. Patients were categorized into two groups according to the extent of TIMI risk score. Patients with low TIMI risk score (0 to 3) were included in Group I and patients with high TIMI risk-score (4 to 14) were include in group II. Patients were followed up in their hospital stay to see the incidence of major cardiac events. Results: A total number of 60 patients with right ventricular infarction of which 30 consecutive patients with low TIMI risk score (0 to 3) were in Group I and 30 consecutive patients with high TIMI risk score (4 to 14) were in Group II. In-hospital mortality was 18.3% in the study populations and it was significantly higher in group II (33.3%) than group (3.3%). The next most common complication is cardiogenic shock followed by complete heart block, Cardiac arrest, VT and 2nd degree heart block. Conclusion: In conclusion the in-hospital mortality in the study populations is significantly higher in group II than group I Journal of National Institute of Neurosciences Bangladesh, July 2022;8(2):143-146

Background: Evaluating potential vaccine side effects is often a prerequisite to combat the coronavirus disease 2019 (COVID-19) pandemic more effectively in a low-resource setting where herd immunity could be the most feasible option. Case report: Here, we present, an 80-year-old man with multiple comorbidities was admitted into the coronary care unit at Ibn Sina Medical College Hospital (Dhaka, Bangladesh) with severe central chest pain and respiratory distress after receiving the first dose of Moderna vaccine on July 26, 2021. On admission, his blood pressure was 110/70 mmHg, pulse 90 beats/min, respiratory rate 22 breaths/min, temperature 36.7°C. He had a vesicular breath sound with bilateral basal crepitations and normal heart sounds. On the ECG, significant changes were observed. Other lab findings were significant troponin-I: 1.72 ng/ml, trace protein and glucose in the urine, total white blood cell count: 12820/cm3; HbA1c, 7.5%; serum creatinine, 1.56 mg/dl; serum electrolytes: sodium 133 mmol/L, chloride 92 mmol/L. The patient had a medical history of prior myocardial infarction, diabetes mellitus, and hypertension but no chronic kidney disease, cerebrovascular disease, or bronchial asthma. After admission, he was treated conservatively with necessary medications and monitored periodically. The patient was diagnosed with acute myocardial infarction with left ventricular failure with acute kidney injury on chronic kidney disease with diabetes mellitus and hypertension. He was discharged from the hospital on day six with proper medicinal support with full recovery. Conclusions: Though acute cardiac complications following COVID-19 vaccines are unusual, this case report can contribute to further molecular research to identify the possible role of vaccine compounds in triggering such complications among the general population.

Chronic rheumatic heart disease is the major contributor of valvular heart disease in this subcontinent. It can affect all the four valves. Among them mitral valve is affected most of the time. Involvement of the mitral valve could be presented in various nonspecific way like chest pain, palpitation, shortness of breath, difficulty in swallowing, change in voice and so on. There are few causes behind the chest pain. Myocardial infraction is one of the important cause. University Heart Journal Vol. 17, No. 1, Jan 2021; 76-78

Fragmented QRS (f-QRS) complex in 12 lead ECG may develop in the background of acute coronary syndrome (ACS). This study was aimed to evaluate the angiographic severity of CAD among non-ST ACS patients having f-QRS in the ECG.This cross-sectional observational study was conducted in Cardiology department of BSMMU. Total 52 non-ST ACS patients who underwent invasive coronary angiography (CAG) were included in two groups according to presence or absence of f-QRS complex. 25 patients were included in f-QRS group and 27 in non-f-QRS group. After CAG, severity of CAD was assessed and compared by number of vessel involvement and degree of vessel stenosis. Patients’ demographic parameters were same in both groups. Depending on the number of vessel involvement, it was found that among f-QRS patient group, highest percentage had triple vessel (32%) followed by double vessel (28%) and single vessel (24%) disease and 16% patient had normal or non-critical epicardial coronary arteries. Among non-f QRS group, highest percentage had normal or non-critical lesions (40.7%) followed by double vessel (25.9%), single vessel (22.2%) and triple vessel disease (7.4%). In conclusion, this study revealed that presence of f-QRS in ECG is associated with more severe form of CAD and once the finding is observed, the particular patient should be targeted for aggressive management. University Heart Journal Vol. 16, No. 1, Jan 2020; 28-32