Effects of hyperuricemia on perinatal outcome in hypertensive disorder of pregnancy

Abstract

The purpose of this study was to detect elevated uric acid level in maternal blood, presumably due to decrease renal urate excretion, for early detection of hypertensive disorder in pregnancy. This study showed that serum uric acid was significantly elevated in all cases of preeclampsia. The present study showed that serum uric acid levels were significantly elevated in eclampsia as compared with the levels in pregnancies complicated by hypertension (p<0.05). The level of uric acid above 4.5 mg/dl is indicative of preeclamptic process and in such cases; the subjects deserve careful and close clinical follow up. Increasing higher concentration of uric acid i.e. 5.7 mg/dl, 6.3mg/dl, and 6.72mg/dl was observed in pregnancy with chronic hypertension, preeclampsia and eclampsia respectively. These results showed that serum uric acid could be used as a sensitive indicator of severity of preeclampsia. Out of 100 cases, there were 20 preterm baby and others such as stillbirth and IUD. So, these entire abnormal fetal outcomes were in the hyperuricaemic group and 5.37 times higher as compared to low serum uric acid group. Mean birth weight of preeclampsia and eclampsia were 2.31kg and 2.30kg respectively compared with 2.5kg in chronic hypertension group.

Hyperuricemia as a Predictor of Perinatal Outcomes in Pregnancy Induced Hypertension

“…In high group it is (37.5%) compare to (12.5%) of the low group and (7.1%) of the middle group with p value (0.004). These results are comparable to those of AU Hosna et al 21 , who classified according to uric acid into 3 groups (group A>5mg/dL, group B5-6.9 and group C>7mg/dL) to see the effect on fetal outcome. In (group A) (63.1%) fetus were found with good out come and (23.7%) with bad outcome, (group B) (27.7%) with good outcome and (32.2%) with bad outcome (group C) (9.2%) with good outcome and (44.1%) with bad outcome.…”

Maternal Serum Uric Acid as an Index of Perinatal Outcomes in Severe Preeclampsia

“…Our study concluded that severe preeclampsia cause adverse outcome to neonatal like low birth weight and low Apgar score at 1st and 5th minutes with significant relation, we found same results in Asma Ul Hosna (2008) and James M. Roberts (2005) who reported patients with severe preeclampsia associated with higher incidence of neonatal adverse outcome [31,7]. In this study, neonatal care unit (NCU) admission in hyperuricemia neonates were lower than normal uric acid neonates with significant relation, we found the same result in Singh (2014) study [29] and opposite result with Acien (1990) show that hyperuricemia neonates more admitted to hospital but both studies were non-significant [32].…”

PREDICTORS OF FETO–MATERNAL MORBIDITY IN PREGNANCY WITH CHRONIC HYPERTENSION

“…Asma Ul Hosna et al showed that mean serum uric acid is higher in hypertensives than controls 11 . In our study the mean uric acid was 6.08, higher than the mean value of 3.61±0.75 mg/dl in late pregnancy 12 .…”