Modern people identify the concept of health and the impact of sports on life. The new coronavirus infection SARS-CoV-2 made significant adjustments to everyday student sports life. The purpose of the study: To study the impact of the new coronavirus infection SARS-CoV-2 on the physical health of students involved in professional and amateur sports. 110 students were examined, among them 62 undergraduates are professional athletes, and 48 undergraduates do amateur sports. Physical load was aerobic. Blood pressure was being measured. ECG, and the level of SaO2 were being recorded. The questionnaire was filled out using Google Forms. Statistical analysis was carried out using the Microsoft Office Excel 2017 software package and Google Forms. The results of the conducted functional examination methods for all students did not exceed the normal parameters. 39 undergraduates from 110 examined students (35.45%) experienced new coronavirus infection SARS-CoV-2. Students, who made the Gam-COVID-Vac vaccine, got ill statistically significantly less than students did without vaccination (29.76% versus 53.85%, p=0.025). We found out the certain correlation, which confirms the following. Students who do professional sports, have adverse reactions to vaccination (r=0.523; p=0.001), as well as they cope with the infection harder (r=0.370; p=0.001). In vaccinated professional athletes, the severity of the course of coronavirus infection was associated with the presence of adverse reactions to vaccination (r=0.320: p=0.016). The deterioration of physical fitness in the post-COVID period correlated with professional sports (r=0.389; p=0.016). Chest discomfort in professional athletes - smokers after infection was associated with the fact of smoking (r=0.221; p=0.014). Conclusions: Gam-COVID-Vac vaccination prevents SARS-CoV-2 new coronavirus infection in students, who do either professional or amateur sports. Professional athletes had weak toleration to Gam-COVID-Vac vaccination. In fact, if a student had adverse reaction to vaccination, he coped with the disease worse in case of infection. The deterioration in physical wellness after experienced coronavirus infection directly correlated with professional sports. Tobacco smoking worsens the course of the post-COVID period in professional athletes.

Activity in the student scientific society (SSC) during higher education is an important factor that affects both the quality of specialist training and the success of their continuous personal and professional development. However, the interest of the majority of students in self-education and work in SSS is relatively low. The problem of involving a medical student in the scientific environment is particularly relevant in the modern social context, which is characterized by the young generation's fascination with the virtual world, which often leads to the development of infantile behavior, inability to independently and clearly plan immediate goals and ways to implement them, and lack of readiness for effective communication in the real world of the medical profession. The purpose of the study was to assess the potential and identify the ways of motivation and the optimal organization of medical students’ research activity as their personal and professional growth driver. The objectives of the study included: a) identification of the main factors motivating students to engage in scientific activities; b) assessment of the association between, on the one hand, the participation of students in the work of the Student Research Society and, on the other hand, the level of their academic achievement and overall personal development; c) search for effective ways to organize students' research work. The study was carried out on the basis of an autonomy-oriented approach which prioritizes a self-determined continuous personal and professional development. As part of the study, a survey was conducted among 230 fifth and sixth-year medical students of Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University. Statistical data processing was carried out using the application package EXCEL and STATISTICA FOR WINDOWS 10.0. The results of the study indicate that participating in the work of the Student Research Society is an important factor in the personal and professional development of medical students, helping to increase their academic performance, improve the quality of knowledge mastering, develop the basis for students’ clinical thinking, inspire their interest in continuous personal and professional development as well as ensure their successful self-realization in the medical profession. It was revealed that continuous personal and professional development requires students to have a certain level of research competence, which is based on their educational research autonomy. It has been established that the most important conditions for medical students’ personal and professional development in research activities are ensuring their research orientation, fostering their personal involvement into research work and enriching their research expertise based on the autonomy-oriented approach. Specific activities are underlined that allow for the implementation of the conditions of students’ personal and professional development in research work and autonomization of the university educational environment.

According global population aging there is an increase in the absolute and relative numbers of people in older age groups. Therefore, senile asthenia (SA) is very relevant. An association between SA and cardiovascular disease has been proven. In addition, there is an increase of aging anemia. At the same time, mortality in patients with anemia, including anemia, which is caused by cardiovascular diseases, increases. Purpose of the study: To study the association of anemia with cardiovascular pathology in patients who have SA syndrome. 168 over 65-year-old patients were examined. The main group contains 60 patients with SA syndrome (37 men, 23 women); control group includes 108 people (68 men, 40 women) without SA syndrome. The median age of patients in the main group did not statistically significantly differ from the median age of people in the control group (82 years ±7.4 [75.00; 84.00] years versus 78 years ±7.1 [65.00; 82.00] years, p=0.605). All patients had a comprehensive geriatric assessment (CGE). Statistically, anemia in patients with SA is diagnosed more frequently in comparison with patients without SA (51.67% vs. 33.33%, p<0.001). Statistically, significant negative correlations were determined among the hemoglobin level and senile asthenia (r=-0.222; p<0.001), hematocrit and senile asthenia (r=-0.224; p<0.001). There are statistically significant direct correlations between anemia in patients with SA with frequent supraventricular extrasystole (r=0.152; p=0.049) and frequent ventricular extrasystole (r=0.154, p=0.047). Conclusion: The association of SA with anemia was confirmed, whereas anemia in patients, who have SA syndrome, affects the occurrence of frequent supraventricular and frequent ventricular extrasystoles.

Цель. Выявить взаимосвязь полиморфизма гена гликопротеина интегрина альфа с развитием ОНМК в семьях больных с фибрилляцией предсердий. Материал и методы. Обследовано 43 пробанда с хронической ФП и ОНМК в анамнезе (25 женщин и 18 мужчин), 54 их родственника 1, 2 и 3 степени род-ства (37 женщин и 17 мужчин). Контрольная группа состояла из 188 человек без сердечнососудистой патологии (96 женщин и 92 мужчин). У всех обследу-емых проводили сбор жалоб, анамнеза, объективный осмотр, электрокардио-графию, эхокардиоскопию. Помимо этого, родственникам пробандов прово-дили холтеровское ЭКГ-мониторирование, тест с физической нагрузкой на наличие пароксизмальных нарушений ритма сердца. У всех обследованных была взята кровь на генетический анализ. Результаты. Генотип СС полиморфизма 807С>Т гена гликопротеина I достоверно реже встречался в группе с ФП и ОНМК при сравнении с контр-ольной группой (23,3% относительно 43,1%, р=0,026, ОШ 0,40, ДИ95% 0,19-0,86%). Генотип СТ полиморфизма 807С>Т гена гликопротеина I достоверно преобладал в группе с ФП и ОНМК при сравнении с контрольной группой (62,8% относительно 42,6%, р=0,026). Суммарно генотипы с алле-лем Т (СТ+ТТ) достоверно чаще выявлялись у больных с ФП и ОНМК при сравнении с контрольной группой (76,8% относительно 57,0%, р=0,026, ОШ 0,40, ДИ 95% 0,19-0,86%). У трех родственников пробандов была выявлена ФП, у двух из них -ОНМК в анамнезе. У родственников с ФП и ОНМК в анам-незе был выявлен генотип СТ полиморфизма 807С>Т гена гликопротеина I . Заключение. Таким образом, в настоящем исследовании показана ассоциа-ция генотипа СТ полиморфизма 807С>Т гена гликопротеина I с развитием ОНМК в семьях больных с ФП. В этих случаях при выявлении генотипа ТТ полиморфизма 807С>Т гена гликопротеина I более целесообразно, по-види-мому, назначение ацетилсалициловой кислоты, а при генотипах СС и СТ -антикоагулянтов. Aim. To assess the associations between the polymorphism of the glycoprotein integrin alpha (I ) gene and acute cerebrovascular events (ACerVE) in the families of patients with atrial fibrillation (AF). Material and methods. In total, 43 probands with chronic AF and ACerVE in medical history (25 women and 18 men) and their 54 first, second, and third-degree relatives (37 women and 17 men) were examined. The control group included 188 people free from cardiovascular disease (96 women and 92 men). All participants underwent standard medical examination, electrocardiography (ECG), echocardiography, and genetic analysis. In addition, the relatives of probands underwent 24-hour Holter ECG monitoring and physical stress test, in order to detect paroxysmal cardiac arrhythmias. GLYCOPROTEIN INTEGRIN ALPHA POLYMORPHISM AND ACUTE CEREBROVASCULAR EVENTS IN THE FAMILIES OF PATIENTS WITH ATRIAL FIBRILLATIONResults. CC genotype of the glycoprotein I 807С>Т polymorphism was significantly less prevalent in patients with AF and ACerVE, compared to the control group (23,3% vs. 43,1%; р=0,026; odds ratio (OR) 0,40; 95 confidence interval (CI) 0,19-0,86%). In contrast, СТ genotype of the glycoprotein I...