According to the World Health Organization (WHO), in the second half of 2022, there are about 606 million confirmed cases of COVID-19 and almost 6,500,000 deaths around the world. A pandemic was declared by the WHO in March 2020 when the new coronavirus spread around the world. The short time between the first cases in Wuhan and the declaration of a pandemic initiated the search for ways to stop the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or to attempt to cure the disease COVID-19. More than ever, research groups are developing vaccines, drugs, and immunobiological compounds, and they are even trying to repurpose drugs in an increasing number of clinical trials. There are great expectations regarding the vaccine’s effectiveness for the prevention of COVID-19. However, producing sufficient doses of vaccines for the entire population and SARS-CoV-2 variants are challenges for pharmaceutical industries. On the contrary, efforts have been made to create different vaccines with different approaches so that they can be used by the entire population. Here, we summarize about 8162 clinical trials, showing a greater number of drug clinical trials in Europe and the United States and less clinical trials in low-income countries. Promising results about the use of new drugs and drug repositioning, monoclonal antibodies, convalescent plasma, and mesenchymal stem cells to control viral infection/replication or the hyper-inflammatory response to the new coronavirus bring hope to treat the disease.
O presente trabalho foi realizado em duas etapas: produção de um guia de estudos para discussão teórica e realização de prática com células animais e humanas em cultura, para alunos de graduação. O impacto da experiência pedagógica nas concepções dos participantes a respeito da cultura celular in vitro foi investigado. Para tanto, os participantes responderam questionário antes do início e ao final do minicurso. Para a verificação da eficiência do minicurso como estratégia de ensino foram realizados três testes: ganho de conhecimento, discriminação e desempenho. A comparação do desempenho dos participantes antes e após o minicurso mostrou que a porcentagem de acertos às respostas do questionário aumentou após o minicurso. Ainda, houve ganho de conhecimento com a atividade realizada e este foi homogêneo. Assim, o minicurso parece ser uma boa estratégia para compor as atividades extracurriculares, contribuindo para a disseminação do conhecimento de temas que não constam na dinâmica curricular.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.