U. (2021).Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition. Nature, 590(7846).

No abstract

Abstract. The most sensitive direct method to establish the absolute neutrino mass is observation of the endpoint of the tritium beta-decay spectrum. Cyclotron Radiation Emission Spectroscopy (CRES) is a precision spectrographic technique that can probe much of the unexplored neutrino mass range with O(eV) resolution. A lower bound of m(ν e ) 9(0.1) meV is set by observations of neutrino oscillations, while the KATRIN Experiment -the current-generation tritium beta-decay experiment that is based on Magnetic Adiabatic Collimation with an Electrostatic (MAC-E) filter -will achieve a arXiv:1703.02037v1 [physics.ins-det]

Assays to study cancer cell responses to pharmacologic or genetic perturbations are typically restricted to using simple phenotypic readouts such as proliferation rate. Information-rich assays, such as gene-expression profiling, have generally not permitted efficient profiling of a given perturbation across multiple cellular contexts. Here, we develop MIX-Seq, a method for multiplexed transcriptional profiling of post-perturbation responses across a mixture of samples with single-cell resolution, using SNP-based computational demultiplexing of singlecell RNA-sequencing data. We show that MIX-Seq can be used to profile responses to chemical or genetic perturbations across pools of 100 or more cancer cell lines. We combine it with Cell Hashing to further multiplex additional experimental conditions, such as posttreatment time points or drug doses. Analyzing the high-content readout of scRNA-seq reveals both shared and context-specific transcriptional response components that can identify drug mechanism of action and enable prediction of long-term cell viability from shortterm transcriptional responses to treatment.

It has been understood since 1897 that accelerating charges must emit electromagnetic radiation. Although first derived in 1904, cyclotron radiation from a single electron orbiting in a magnetic field has never been observed directly. We demonstrate single-electron detection in a novel radio-frequency spectrometer. The relativistic shift in the cyclotron frequency permits a precise electron energy measurement. Precise beta electron spectroscopy from gaseous radiation sources is a key technique in modern efforts to measure the neutrino mass via the tritium decay end point, and this work demonstrates a fundamentally new approach to precision beta spectroscopy for future neutrino mass experiments. For over a century, nuclear decay electron spectroscopy has played a pivotal role in the understanding of nuclear physics. Early measurements of the continuous β-decay spectrum [1] provided the first evidence of the existence of the weak force and the neutrino [2], and immediately hinted that the neutrino mass is small. Continuing this tradition, present efforts to directly measure the mass of the neutrino rely on precision spectroscopy of the β-decay energy spectrum of 3 H. Because the value of the neutrino mass is an input to the standard model of particle physics as well as precision cosmology, a precision measurement of the neutrino mass would represent a significant advance in our description of nature.The sensitivity of 3 H -based neutrino mass measurements has been improving over the past 80 years as a result of increasingly powerful electron spectrometry techniques [3][4][5][6]. The most sensitive experiments to date place a limit on the electron-flavor-weighted neutrino mass m β ≤ 2.05 eV=c 2 at 95% C.L. [7][8][9], m 2 β ¼