Plasmodium falciparum, the agent of malignant malaria, is one of mankind's most severe scourges, mainly in the tropic world. Efforts to develop preventive vaccines or remedial drugs are handicapped by the parasite's rapid evolution of drug resistance. Here, we presented an advance work on examination of antimalarial component from marine life of Xestospongia sp., the study is based on hexane extraction method. The premier result, we obtained five fractions. Among these five fractions, the fourth has the most potent inhibitory against the growth of P. falciparum 3D7 with an IC50: 7.13 µg/mL. A compiled spectrum analysis, FTIR, 1H-NMR and GC-MS, revealed that the fourth fraction consisted abundantly of two secondary metabolites such as flavonoids and triterpenoids. Finally, our results suggest a plausible structure rooted to the base of ibuprofen.

Akway (Drimys beccariana, Gibbs) is a plant endemic to Papua highlands contained in Manokwari. D. beccariana is used for traditional malaria treatment in West Papua. The methanol extract of stem bark of D. beccariana showed antimalarial activity against Plasmodium falciparum parasites, in vitro. Methanol extract of D. beccariana is partitioned between water and n-hexane (1:9), and ethyl acetate. Furthermore, ethyl acetate extract was separated through several combination of chromatography techniques on silica gel, resulting in three known compounds (1-3). The chemical structures of compounds (1-3) were identified based on IR, UV/Vis, 1H NMR and 13C NMR, and MS data as 5,3’-dihydroxy-7,4’-dimethoxyflavone (1), 5,7-dihydroxy-4’-methoxyflavone (2), and 5-hydroxy-7,3’,4’-trimethoxyflavone (3). Compounds 1-3 showed strong antiplasmodium against 3D7 strain of P. falciparum with IC50 values of 0.002, 0.005, and 0.001 micro Molar, respectively. This result indicates that stem bark of D. beccariana is a promising source of antimalarial agents, and merits further investigation.

<p><em>The plant Akway (Drimys beccariana.</em>Gibbs<em>) is endemic to Papua and is frequently used traditionally by the Arfak tribe as a medicinal plant. We extract the plant by maceration with ethanol. The antibacterial test  is done by Agar diffusion method. As microba test  we used Escheresia coli and Bacillus subtilis. Result obtained from fitochemistry skrinning of the leaf and bark contained alkaloid, flavonoid, steroid, tannin, glikosida, saponin, triterpenoid, steroid and  fenolik. Concentration of active substances from the leaf are flavonoid (0,3680%) and tanin (10.33 %); while from the bark flavonoid 18.35%  and tanin (27.65%).  Antibacterial test showed that the plant could be used as an antibaterial substances. The test showed a moderate up to a strong blocking against Escherecia coli (a gram negative bacteri) and Bacillus subtilis (a gram positive bacteri).  Thus it could be concluded that the Akway plant contain a substance with a bacteriostatic nature that could block the activity of the bacteri.</em></p>

This research aims to determine the improvement of the process and learning outcomes of the buffer solutions topic by applying the Problem-based Learning (PBL) model. This research is based on Classroom Action Research (CAR) takes place in two cycles, with several stages including planning, implementing, observing, and reflecting. Our present study used 17 students of natural science 11th grade SMA Advent Manokwari. The data was obtained from teachers and students. The data collection method used cognitive learning outcomes and observation. The data analysis uses descriptive analytic techniques. Our findings showed that the application of the PBL model can improve the quality of the learning process on the buffer solutions topic; the application of the Problem-based Learning (PBL) learning model has increased from cycle I with an average grade of 65.36 and a percentage of passing grades of 41% and cycle II with an average grade of 83.66 and a percentage of passing grades of 88%.

Penelitian ini bertujuan: 1) untuk meningkatkan hasil belajar peserta didik dengan menggunakan model pembelajaran Project Based Learning (PJBL) pada materi sistem koloid, dan 2) untuk melihat besar persentase ketuntasan hasil belajar peserta didik kelas XI IPA 1 SMA Kristen YABT Manokwari. Metode penelitian yang digunakan adalah metode Penelitian Tindakan Kelas (PTK) yang dilaksanakan sebanyak 2 (dua) siklus dengan  masing-masing siklus terdiri dari 4 (empat) tahapan yaitu: (a) perencanaan, (b) tindakan, (c) observasi, dan (d) refleksi. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah berupa observasi, wanwancara dan tes belajar. Sedangkan instrumen validitas data menggunakan validitas isi dan validitas konstruk. Data yang telah diperoleh dianalisis menggunakan teknik analisis deskriptif dengan bantuan software Microsoft Excel 2013 dan disajikan melalui tabel histogram, grafik, perhitungan rata-rata serta persentase ketuntasan hasil belajar peserta didik. Hasil penelitian menunjukkan bahwa: a) penerapan model pembelajaran Project Based Learnig (PJBL) dapat meningkatkan hasil belajar peserta didik kelas XI IPA 1 SMA Kristen YABT Manokwari pada materi sistem koloid; b) besar persentase ketuntasan hasil belajar peserta didik yang diperoleh mengalami peningkatan pada siklus I sebesar 43% dengan kriteria rendah dan siklus II sebesar 83% dengan kriteria tinggi.