Background: Inflammation is a normal protective response to tissue injury caused by physical trauma, chemicals, or microbiological substances. The manifestation clinic of inflammation is pain. Miana leaves (Coleus atropurpureus Benth.) have chemical contents such as essential oils, phenols, flavonoids, and polyphenols. Flavonoids can protect lipid membranes from damage and inhibit cyclooxygenase, which is the first pathway for the synthesis of pain mediators such as prostaglandins. Objectives: This study aims to determine the effectiveness of ethanol extract of Miana leaves (Coleus atropurpureus Benth) (EEML) as analgesic and anti-inflammatory in rats (Rattus novergicus). Material and Methods: This study used The Pre-Posttest-Only Control Group Design,  twenty male rats were divided into 5 groups namely negative control, positive control was given diclofenac sodium, treatment with EEML dose of 150 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW. Test of Antiinflammatory uses the Rat Hind Paw Edema method where the condition of inflammation in rats is induced with 5% egg white by subplantar. The measurement of edema in rat feet used a caliper every 30 minutes for 5 hours. While The measurement of analgesic testing used the method of nociception test which evaluates pain responses such as Staggering Gait, Vocalization, and Writhing. Results: The results of the measurement of the inflammatory parameters were analyzed with the One Way Anova test for the width of edema foot and Kruskal Walis for the thickness of edema foot. While the results of observing the pain response were analyzed with the Kruskal Walis test. Conclusions: This study concluded that the ethanol extract of Miana leaves has anti-inflammatory analgesic especially at a dose of 600 mg/kg BW which results are non-significant (p> 0.05) with a positive control group (sodium diclofenac).

Free radicals can caused damage cell and tissue which lead to various disease then needed antioxidant as radicals scavenging. The objective of this study was to determine antioxidants activity leaves of Scaevola taccada (Gaertn.) Roxb based to DPPH (1,1-diphenyl-2-picrilhydrazil) free radicals scavenging. The study was initiated with sample extraction by maceration used ethanol then partitioned with ethyl acetate. The obtained fraction tested to antioxidant activity DPPH radicals. Testing done in five series concentration is 50 ppm, 100 ppm, 200 ppm, 300 ppm and 400 ppm, which compared to antioxidant activity vitamin C and BHT (butylatedhydroxytoluene). Activity against free radicals is measured with at a spectrophotometer UV-VIS wavelength 517 nm and calculated value ES50. The result showed the value ES50 of a leaves ethyl acetate fraction of 1473 ppm while ES50 vitamin C and BHT of 9.054 ppm and 29.067 ppm, respectively. Therefore, obtained results showed that ethyl acetate fraction Scaevola taccada (Gaertn.) Roxb leaves has weak activity compared vitamin C and BHT as positive control with ES50 values respectively 1473.064 ppm, 9.054 ppm and 29.067 ppm.

Rheumatoid arthritis is an chronic autoimmune disease, which is characterized by inflammation and degradation of the joints and cartilages. Rheumatoid therapy is currently using immunosuppressant drugs, nonsteroidal anti-inflammatory drugs and corticosteroids. Treatment of chronic rheumatoid can trigger side effects. Syzygium polyanthum leaves contain alkaloid compounds, flavonoids, saponins, tannins and essential oils consist of citral and eugenol which are thought to be potential as antirheumatoid. This study aims to determine the effect antirheumatoid arthritis and effective dose of ethanol extracts of  Syzygium polyanthum  leaf. This study used 15 male rats. Treatment started by measuring foot volume using a pletismometer and then inducting CFA intraplantary as much as 0,1 mL on day 1 and left until day 16th. On the day 17th a foot volume and arthritis index was measured and then treated until the day 30th. The animals were divided into 5 groups: negative control (Na. CMC 1%), positive control (methylprednisolone dose 1.646 mg / kg BW), ethanol extractof Syzygium polyanthum  leaf at a dose of 75 mg / kg, 150 mg / kg and 300 mg / kg. On the day 31st, foot volume and arthritis index measurements were taken again. The results showed a decrease in foot volume and arthritis index after given of the extract. Foot volume difference data were analyzed using the One Way Anova test followed by the Post Hoc LSD test. The difference between the arthritis index data was analyzed using Kruskal-Wallis followed by the Mann-Whitney test. Statistical results show that positive control has the same effect as extract (P> 0.05). Based on the results of statistical analysis of inflammation of the foot volume and the arthritis index shows that the ethanol extract of Syzygium polyanthum  leaf had an effect as an antirheumatoid arthritis

Leaf cherry (Muntingia Calabura L) empirically been used by the public as an anti-inflammatory drug. Cherry leaf contains flavonoids are thought to have antioxidant effects. This study has been tested antiinflammatory effect of ethanol extract of leaves of cherry (Muntingia Calabura L) in mice (Mus musculus). A total of 15 mice were divided into 5 groups of 3 animals. Group I (control) are given Na.CMC 1% w/v, Group II, III, and IV (treatment) were given cherry leaf extract ethanol concentration of 1% w / v, 3% w / v, and 5% w / v, as well as groups V (comparison) given Diclofenac Sodium 0.195 mg / 30 gBW. Before treatment all groups karagen induced with 1% w / v in intraplantar. Antiinflammatory effect was measured using pleytismometer. The results were analyzed statistically by one-way ANOVA method. The results showed that the ethanol extract of cherry leaf has anti-inflammatory effects and the concentration of 3% and 5% w / v has an effect no different to that diclofenac sodium.

Abstrak: Tanaman sereh wangi (Cymbopongon nardus L) merupakan sumber minyak atsiri yang diperoleh dari penyulingan uap. Sereh wangi memiliki banyak manfaat seperti pelancar pernapasan, pewangi ruangan, minyak pijat, bahan aroma terapi, obat nyamuk, produk kecantikan, pelepas stres, parfum, obat trdisional kesehatan, dan bioaktif bahan bakar minyak. Pada saat ini penggunaan minyak sereh wangi Aceh belum ada dalam bentuk lotion, sehingga perlu dilakukan sebuah inovasi, agar minyak sereh wangi Aceh bisa kembali menjadi prioritas terutama dibidang minyak atsiri, seperti dibuat dalam bentuk skin lotion. Penelitian ini bertujuan untuk mengetahui penambahan minyak sereh wangi dan triethanolamin terhadap skin lotion yang dihasilkan. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) faktorial dengan 2 faktor, faktor pertama adalah Triethanolamin (T) dan minyak sereh wangi (M). Analisis yang dilakukan antara lain yaitu uji viskositas dan uji hedonik. Hasil penelitian menunjukkan bahwa Konsentrasi triethanolamin (T) berpengaruh sangat nyata (P0.01) terhadap viskositas lotion. Formulasi Skin Lotion Minyak sereh wangi dengan Variasi Konsentrasi TriethanolaminAbstract: Citronella plants (Cymbopongon nardus L) are sources of essential oils obtained by steam distillation. Citronella has many benefits such as relieving respiratory, air fresheners, massage oils, aroma therapy ingredients, insect repellent, beauty products, stress relief, perfume, traditional, health medicines, and bioactive fuel oils. Nowadays, Aceh Citronella oil has not been used as lotion yet, regarding this fact, it needs an innovation, so that Aceh Citronella oil can become a priority, especially in the field of essential oils, for example, it can be made as a skin lotion. This research used factorial randomized block design (RAK) with 2 factors, the first factor is Triethanolamine (T) and Citronella oil (M). The analysis carried out included the viscosity test and the hedonic test. The results showed that the concentration of triethanolamine (T) had a very significant effect (P 0.01) on the viscosity of the lotion.