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In previous reports one of us (M) and his associates (1, 2) have shown that hexylresorcinol aids in the absorption of insulin from the gastrointestinal tract of dogs. It has since been shown that other derivatives, the octyl and heptyl resorcinols (3) and the pentyl, butyl, and propyl resorcinols likewise are active in this physiologic process; the last two, however, less so than the higher compounds. Ethyl resorcinol proved completely inactive, as have the acyl resorcinols and the butyl ester of f8-resorcinol (4). Reports on the effects of other substances found to retard digestion of insulin will be made in later papers.None of the resorcinols having proved superior to the hexyl compound, it was decided to try this one on a series of diabetic patients.'At the time of the report before the National Academy of Sciences (5) was widely copied in the lay press. The story grew to the point where " Time " reported " a perfected compound of insulin and hexylresorcinol which may be swallowed as a tablet." Not a word was said about tablets either in the paper read before the Academy, the abstract published in Science, or in the statement given to the press along with statements from other speakers.

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3. In two-thirds of the cases there was a delay of over six months from onset of symptoms to the final operation. In many eases the delay was much longer-up to eighteen years. 4. Only 2.4 per cent of the fistulous tracts examined pathologically were tuberculous although 34 patients had had tuberculosis elsewhere in the body and 15 subsequently died of this disease.5. Multiple internal openings occur sufficiently often to necessitate a search for them in each case.6. Recent end results have been obtained in 280 cases and show the percentage of cure to be 92 per cent in those operated by a complete incision and drainage method. An analysis of the results from other operative procedures is also given.

Following the method of perfusion introduced by Clarkf, the effect of pancreatic perfusates upon the carbohydrate metabolism of entire animals was studied. The respiratory metabolism, the blood sugar, and the D:N ratio were studied in cats and dogs after depancreatization.Perfusates were made by perfusing aseptically and a t body teniperature the pancreases of cats, dogs, pigs, and oxen with Locke's solution. The first perfusates were made with an alkaline mediuni, later perfusates were made with Locke's solution modified by the substitution of llCl \-arying in strength from 0.1 per cent. to 0.7 per cent. for sodiuni bicarbonate.Respiratory quotients were obtained by a modified Jaquet method, the animal being confined in a respiration chamber through which a continuous stream of air was drawn for ventilation and from which a continuous sample of air was removed for analysis. In a later modification the stream of air from the respiration chamber n.as directed into a large gasometer for a twenty-minute period aiid the samples for aiialysis withdrawn from this total volume. Analyses were made by the Henderso:] and Bailey modification of Haldane's apparatus. The respiration chamber was frequently cliecked by analyses of outside air and by burning alcohol in it. D :N ratios and respiratory quotients typical for diabetes were obtained in the depancreatized animals.Following the administration of sugar in the form of destrose or siicrose by stomach tube pancreatic perfusates were given s u bcu t a n e o us1 y , i 11 t ra ve n o u s 1 y , a nd in t rape r it o nea 11 y . S i g iii fica n t increases were shown in the respiratory quotients and marked 1 Clark, Adlllont H., JOUT. Err. Med., 1916, sxiv., 621.