Background SARS-CoV-2, which causes the coronavirus disease (COVID-19), presents high rates of morbidity and mortality and has affected thousands of people around the world. The search to eliminate SARS-CoV-2 is ongoing and urgent. This systematic review seeks to assess whether photodynamic therapy (PDT) could be effective in SARS-CoV-2 inactivation. Methods The focus question was: Can photodynamic therapy be used as potential guidance for dealing with SARS-CoV-2?”. A literature search, according to PRISMA statements, was conducted in the electronic databases PubMed, EMBASE, SCOPUS, Web of Science, LILACS, and Google Scholar. Studies published from January 2004 to June 2020 were analyzed. In vitro and in vivo studies were included that evaluated the effect of PDT mediated by several photosensitizers on RNA and DNA enveloped and non-enveloped viruses. Results From 27 selected manuscripts, 26 publications used in vitro studies, 24 were exclusively in vitro , and two had in vitro / in vivo parts. Only one analyzed publication was exclusively in vivo . Meta-analysis studies were unfeasible due to heterogeneity of the data. The risk of bias was analyzed in all studies. Conclusion The in vitro and in vivo studies selected in this systematic review indicated that PDT is capable of photoinactivating enveloped and non-enveloped DNA and RNA viruses, suggesting that PDT can potentially photoinactivate SARS-CoV-2.

In recent years, propolis extract (PE) has demonstrated antimicrobial and anti-inflammatory properties. The aim of this study was to evaluate the antifungal activity of a bioadhesive thermoresponsive system containing 16% propolis (BTSP 16%) against Microsporum canis, Nannizzia gypsea, Trichophyton mentagrophytes, and T. rubrum. We also evaluated PE alone against the same strains. The results showed that both PE and BTSP 16% significantly reduced the fungal viability of all evaluated strains. In addition, they interacted with the biofilm of these species in different stages of biofilm formation. We observed that the bioadhesive and thermoresponsive properties of BTSP 16% prolonged propolis presence at infection sites, leading to positive results against planktonic fungal cells and mature biofilms. These characteristics make this formulation a valuable alternative treatment for dermatomycosis.

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Diabetes Mellitus é considerada fator predisponente para dermatomicoses, entretanto, não é bem descrito o porquê dessa associação, especialmente em se tratando de moradores em zona rural. Objetivo: Avaliar a ocorrência de dermatomicoses em diabéticos, maiores de 50 anos, residentes na zona rural de Ivatuba, Paraná, Brasil. Método: Participantes do programa HiperDia da Unidade Básica de Saúde responderam a um questionário e forneceram amostras de sangue e lesões tegumentares para investigação laboratorial. Resultados: Foram incluídos no estudo 45 indivíduos, dos quais 37 apresentavam lesões tegumentares e fungos foram detectados em 17 deles (45,9%). Não houve diferença significativa nos parâmetros metabólicos avaliados, entre indivíduos com e sem micose, nem quanto a hábitos da vida rural. Enquanto isso, alguns fungos, aleatoriamente avaliados, foram resistentes à fagocitose in vitro e sobretudo à morte por fagócitos removidos de camundongos diabéticos. Conclusão: a taxa de dermatomicose encontrada em diabéticos foi alta e pode estar relacionada à falha na ativação de fagócitos.