No abstract

Colorectal cancer (CRC) is one of the most common and reoccurring diseases, as well as the world’s second largest cause of mortality. Despite existing preventative, diagnostic, and treatment methods, such as chemotherapy, the number of instances rises year after year. As a result, new effective medications targeting specific checkpoints should be developed to combat CRC. Natural compounds, such as curcumin, have shown significant anti-colorectal cancer characteristics among medications that can be used to treat CRC. These chemicals are phenolic compounds that belong to the curcuminoids category. Curcumin exerts its anti-proliferative properties against CRC cell lines in vitro and in vivo via a variety of mechanisms, including the suppression of intrinsic and extrinsic apoptotic signaling pathways, the stoppage of the cell cycle, and the activation of autophagy. Curcumin also has anti-angiogenesis properties. Thus, this review is aimed at emphasizing the biological effect and mode of action of curcumin on CRC. Furthermore, the critical role of these substances in CRC chemoprevention was emphasized.

This study aimed at carrying out the characteristics existing in slaughterhouses work scenarios, taking into account the aspects that corroborate to ensure employees' health conditions, such as physical, chemical, biological risks, and, mainly, ergonomic. It is noted that the slaughterhouses have several changes that compromise the physical conditions of those who provide practical actions in these service spaces. The data from this research are seasoned due to issues involving ergonomic aspects such as Work-Related Musculoskeletal Disorders (WRMD) and temperature, humidity, risky materials, noise, extensive workloads, among other factors that compromise, significantly, the health of employees. In short, the scenarios lack changes and improvements in conditions of caring for the well-being of employees, as well as envisioning the need to ensure conditions for improving their materials, proposing a complementation in the training of their workers.

The brain-gut axis evidences the interactions between the gastrointestinal system and the brain in a general context. This physiological system is a mutual balance connection between two individual organs of the body in response to internal and external changes. It is extremely important to appreciate the current concepts that involve this system to understand brain-gut interaction, as well as to highlight the insertion of the axis today, using clinical conditions, neuropsychiatric disorders, intestinal microbiota, immunomodulators, and scientific evidence to verify and highlight axis activity in the human body. In this sense, there is a consistent background in literature supporting the physiological development and shaping of the gut in brain disorders by a constant interplay mediated by the several products originating from the microbiota.

Com um estilo de vida cada vez mais agitado, o consumidor busca por conveniência, com produtos de preparo fácil e rápido. Nesse contexto, destacam-se os produtos cárneos reestruturados empanados tipo nuggets. O objetivo do estudo foi desenvolver e avaliar sensorialmente nuggets elaborados com carne suína. Foram preparadas três formulações com diferentes concentrações de gordura suína. Realizou-se a avaliação microbiológica das formulações, as quais não apresentaram contaminação microbiana. A avaliação sensorial de aceitabilidade foi conduzida empregando uma escala hedônica de 9 pontos para os atributos maciez, sabor, aroma, crocância, aparência e impressão global do produto. Além disso, com o objetivo de avaliar a opinião dos consumidores frente ao produto, foi aplicado um teste de intenção de compra com escala de 5 pontos. Os resultados obtidos mostram que as três amostras obtiveram nota maior ou igual a 7 (gostei regularmente) por mais de 90% dos julgadores, sendo que nenhuma nota inferior a 5 foi atribuída às formulações, indicando baixa rejeição dos produtos. A intenção de compra também foi elevada, sendo que a porcentagem de julgadores que indicaram notas 4 e 5, que correspondem respectivamente aos termos “provavelmente compraria” e “certamente compraria” foi de 86.4, 81.8 e 84.5% para a amostra A, B e C, respectivamente. O trabalho demonstrou que os nuggets à base de carne suína e com diferentes teores de gordura obtiveram ótima aceitabilidade e intenção de compra, apresentando-se como alternativa potencial de inserção no mercado consumidor.