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Introduction: Topical anesthetics are of great interest in pediatric dentistry because they act on the peripheral nerves reducing the sensation of pain when applying local anesthetics. Objective: To analyze the most recent literature on topical anesthetics: benzocaine, lidocaine, eutectic mixture of local anesthetics (EMLA), generalities, doses and presentations, uses and adverse effects. Methodology: Articles on topical anesthetics in pediatric dentistry were analyzed in the databases PubMed, SCOPUS and Google academic with emphasis on the last 5 years. This was done with the words: "dental anesthetic", "benzocaine", "lidocaine", "Pediatric dentistry", "EMLA". Results: It has been found that 20% benzocaine is the most used anesthetic, its main use is before local anesthetic puncture, it has a pleasant taste, however, high rates of allergies have been reported. As for lidocaine, it is effective when applied in 1 minute, its 10% aerosol presentation has presented the best results, its toxicity levels are low but it has an unpleasant taste. EMLA is a mixture of lidocaine 2.5% and prilocaine 2.5%, it is used before puncture, when placing orthodontic separators and in small biopsies, its application time is 2 to 10 minutes and it can cause numbness in unwanted areas. Conclusion: Currently there is no topical formulation that completely eliminates the pain caused by needle puncture, therefore, products with greater efficacy are awaited.

Introduction: Tannerella forsythia, is an anaerobic, Gram-negative microorganism closely related to periodontal disease. Factors such as poor dental hygiene, fixed orthodontic appliances, etc. can cause dysbiosis in the bacterial community. Objective: To analyze the literature about the epidemiology, diagnostic methods, oral manifestations, relationship with systemic diseases and treatment of Tannerella forsythia in orthodontic patients. Methodology: Using the keywords "T. forsythia", "orthodontics", "oral manifestations", "diagnostics", "treatment" and "epidemiology", the main public databases were searched, with emphasis on the last 5 years. It was evaluated with the PRISMA and AMSTAR-2 guidelines. Results: At the national level, in 2019, cases of gingivitis and periodontal disease ranked fifth among the twenty main causes of diseases. As a diagnostic method, most of the studies used molecular biology (PCR) for the identification of bacterial DNA. Very few studies performed cultures for identification. T. forsythia is capable of inducing characteristic signs of gingivitis and periodontal disease. Non-surgical mechanical therapy remains the gold standard in its treatment. There are multiple diseases that can be related to the presence of T. forsythia, so its medical importance becomes more relevant and its control, essential. Conclusion: T. forsythia is closely related to periodontal disease. Its presence is mainly found in the easily accumulated plaque in patients with fixed appliances. It is essential to diagnose it for a treatment that can avoid harm to the patient.

Introduction: Due to its ability to prevent chromosomal damage, the genus Equisetum is likely to have an interesting field of potential use in clinical applications. Objective: To analyze the literature on Equisetum, particularly its anti-inflammatory, antibacterial and cytotoxicity effects, from a dental approach. Methodology: In PubMed, Science Direct, Google Schoolar searched for information with combinations of the keywords: Equisetum, anti-inflammatory, antibacterial, and cytotoxicity. Results: Equisetum possesses anti-inflammatory properties, inhibiting proinflammatory cytokine production and modulating T and B lymphocyte activity. It has antibacterial and antifungal effects against gram positive and gram negative bacteria, including S. mutans and Candida. Administered in controlled doses, toxicity with clinical signs is not detected, however, it shows antitumor effect. Conclusion:Equisetum has anti-inflammatory and antibacterial properties and does not show cytotoxicity, it is a potential therapeutic agent for oral treatments.

Introduction: Maintaining oral health becomes a challenge when Alzheimer's disease progresses to the intermediate and late stages. Objective: To analyze the literature on Alzheimer's disease and its relationship with dentistry in high impact journals, with a focus on etiology, diagnostic methods, treatment, dental clinical characteristics and dental management. Methodology: The search was carried out in the databases PubMed, SCOPUS and Google Scholar, using the terms "Alzheimer's", "etiology", "diagnostic methods", "treatment", "dental clinical characteristics" and "dental management", together with logical Boolean operators OR and AND. Results: It is important to know that the etiology of Alzheimer's disease is uncertain; the most widely used diagnostic methods for this disease are biomarkers. There is no drug capable of alleviating Alzheimer's disease. It is very common to find different oral diseases due to the lack of hygiene presented by patients suffering from Alzheimer's disease, so it is important to give education to their caregivers to perform oral hygiene. Conclusion: Currently, the issue of the effects of Alzheimer's disease on dentistry has been neglected. It is important to pay more attention to it and to educate caregivers about the possible oral diseases involved in the future as a consequence of poor oral care.