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The psychological consequences of diets that restrict energy intake are disputed. Our observations suggest that irritability and waking early in the morning were common in the third week of the diet. Whether these behavioural changes were related to decreased plasma concentrations of tryptophan could be investigated by supplementing the diet with tryptophan. There would be considerable interest if supplementation improved the compliance with, and effectiveness of, dieting. Unfortunately, pharmaceutical preparations of trvptophan have been withdrawn because of their suspected association with the eosinophilia-myalgia syndrome." It may be feasible, however, to investigate the effect of supplementation with tryptophan byrmanipulating the dietary intake of tryptophan and other amin acids. Trptophan remains important to the understanding of the relation between food intake and brain function. We thank Norma Brearley for preparing the manuscript.

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